Is There a Role for the Vascular Renin-Angiotensin System in the Determination of Vascular Structure?

1991 ◽  
Vol 28 (1-3) ◽  
pp. 224-230 ◽  
Author(s):  
M.J. Mulvany
Keyword(s):  
Renin Angiotensin System ◽  
Vascular Structure ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Distribution of Polymorphic Markers of Genes Encoding the Renin-angiotensin System (ACE, AGT, AGTR1), ITGB3, PPARG, Pparg in Patients With Essential Hypertension Depending on the Age

2022 ◽  
Vol 16 ◽  
pp. 105-111
Author(s):  
Tatyana Zotova ◽  
Madina Azova ◽  
Anastasia Lukanina ◽  
A. Ait Aissa ◽  
Mikhail Blagonravov
Keyword(s):  
Essential Hypertension ◽  
Renin Angiotensin System ◽  
Population Data ◽  
Polymorphic Markers ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Leading Role ◽  
Genes Encoding ◽  
Predisposition Genes

Essential hypertension (EH) is a multifactorial disease with a hereditary predisposition. Genes encoding the renin-angiotensin system (RAS) play a leading role in the stabilization of elevated BP in the course of EH, which determines the relevance of our clinical and genetic study. The study was based on the determination of the frequencies of polymorphic markers of the AGT, AGTR1, ACE, ITGB3, PPARG genes in 2 groups, depending on the age of patients (up to 60 years - group1, n=18, and after 60 years - group2, n=31), for the intergroup frequencies comparison and comparison of group frequencies with population data. Genotyping by gene polymorphisms was performed by real-time polymerase chain reaction. 24-hour ambulatory BP monitoring (ABPM) and Holter HR monitoring were conducted. Phenotypic features of the course of EH were accompanied by changes in the frequency characteristics of the studied genotypes. In patients of group 1, an increase in the frequency of protective genotypes of the ACE(II) and ITGB3(TT) genes was observed (p=0.004;0.015), which confirms the hypothesis of a possible favorable course of EH in patients under 60 years.

Role of genetic variability in the renin-angiotensin system in diabetic and nondiabetic renal disease

2001 ◽  
Vol 21 (6) ◽  
pp. 580-592 ◽  
Author(s):  
Arnold Boonstra ◽  
Dick de Zeeuw ◽  
Paul E. de Jong ◽  
Gerjan Navis
Keyword(s):  
Genetic Variability ◽  
Renal Disease ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

Importance of the Renin-Angiotensin-System in human granulosa lutein cells – RAS in granulosa cells

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
D Herr ◽  
WC Duncan ◽  
G Hack ◽  
R Konrad ◽  
R Kreienberg ◽  
...  
Keyword(s):  
Granulosa Cells ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin
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