High Incidence of Malignant Pleural Mesothelioma in Neighbouring Villages of Northwestern Greece

Respiration ◽  
1987 ◽  
Vol 51 (4) ◽  
pp. 266-271 ◽  
Author(s):  
Stavros H. Constantopoulos ◽  
Vasiliki D. Malamou-Mitsi ◽  
John A. Goudevenos ◽  
Mathildi P. Papathanasiou ◽  
Nicolas A. Pavlidis ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
High Incidence ◽  
Northwestern Greece

scholarly journals DNA Methylation of FKBP5 as Predictor of Overall Survival in Malignant Pleural Mesothelioma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3470
Author(s):  
Giovanni Cugliari ◽  
Chiara Catalano ◽  
Simonetta Guarrera ◽  
Alessandra Allione ◽  
Elisabetta Casalone ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Overall Survival ◽  
Malignant Pleural Mesothelioma ◽  
P Value ◽  
Pleural Mesothelioma ◽  
Lymphocyte To Monocyte Ratio ◽  
High Incidence ◽  
Aggressive Tumor ◽  
Independent Marker ◽  
The Relationship

Malignant pleural mesothelioma (MPM) is an aggressive tumor with median survival of 12 months and limited effective treatments. The scope of this study was to study the relationship between blood DNA methylation (DNAm) and overall survival (OS) aiming at a noninvasive prognostic test. We investigated a cohort of 159 incident asbestos exposed MPM cases enrolled in an Italian area with high incidence of mesothelioma. Considering 12 months as a cut-off for OS, epigenome-wide association study (EWAS) revealed statistically significant (p value = 7.7 × 10−9) OS-related differential methylation of a single-CpG (cg03546163), located in the 5′UTR region of the FKBP5 gene. This is an independent marker of prognosis in MPM patients with a better performance than traditional inflammation-based scores such as lymphocyte-to-monocyte ratio (LMR). Cases with DNAm < 0.45 at the cg03546163 had significantly poor survival compared with those showing DNAm ≥ 0.45 (mean: 243 versus 534 days; p value< 0.001). Epigenetic changes at the FKBP5 gene were robustly associated with OS in MPM cases. Our results showed that blood DNA methylation levels could be promising and dynamic prognostic biomarkers in MPM.

scholarly journals Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dearbhaile Catherine Collins ◽  
Raghav Sundar ◽  
Anastasia Constantidinou ◽  
David Dolling ◽  
Timothy Anthony Yap ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Metastatic Disease ◽  
Distant Metastases ◽  
Peritoneal Metastases ◽  
Pleural Mesothelioma ◽  
Clinical Workflow ◽  
Distant Metastatic Disease ◽  
High Incidence ◽  
Trial Protocols ◽  
Metastatic Sites

Abstract Background Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking. Methods In this retrospective study, we reviewed a cohort of 164 MPM patients referred to a Phase I trials unit, aiming to describe identified metastatic sites, and correlate with clinical outcomes. Results 67% of patients were diagnosed with distant metastatic disease with a high incidence of bone (19%), visceral (14%), contralateral lung (35%) and peritoneal metastases (22%). Peritoneal metastases were more likely in epithelioid versus biphasic/ sarcomatoid MPM (p = 0.015). Overall survival was 23.8 months with no statistical difference in survival between those with distant metastases and those without. Conclusions This report highlights the frequency of distant metastases and encourages further radiological investigations in the presence of symptoms. In particular, given the relatively high incidence of bone metastases, bone imaging should be considered in advanced MPM clinical workflow and trial protocols. The presence of distant metastases does not appear to have prognostic implications under existing treatment paradigms. This cohort of MPM patients gives an indication of patterns of metastatic spread that are likely to become prevalent as prognosis improves with emerging treatment paradigms.

scholarly journals Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

2020 ◽  
Author(s):  
Dearbhaile Catherine Collins ◽  
Raghav Sundar ◽  
Anastasia Constantidinou ◽  
David Dolling ◽  
Timothy Anthony Yap ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Metastatic Disease ◽  
Distant Metastases ◽  
Peritoneal Metastases ◽  
Pleural Mesothelioma ◽  
Clinical Workflow ◽  
Distant Metastatic Disease ◽  
High Incidence ◽  
Trial Protocols ◽  
Metastatic Sites

Abstract BackgroundMalignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking. MethodsIn this retrospective study, we reviewed a cohort of 164 MPM patients referred to a Phase I trials unit, aiming to describe identified metastatic sites, and correlate with clinical outcomes. Results67% of patients were diagnosed with distant metastatic disease with a high incidence of bone (19%), visceral (14%), contralateral lung (35%) and peritoneal metastases (22%). Peritoneal metastases were more likely in epithelioid versus biphasic/ sarcomatoid MPM (p=0.015). Overall survival was 23.8 months with no statistical difference in survival between those with distant metastases and those without.ConclusionsThis report highlights the frequency of distant metastases and encourages further radiological investigations in the presence of symptoms. In particular, given the relatively high incidence of bone metastases, bone imaging should be considered in advanced MPM clinical workflow and trial protocols. The presence of distant metastases does not appear to have prognostic implications under existing treatment paradigms. This cohort of MPM patients gives an indication of patterns of metastatic spread that are likely to become prevalent as prognosis improves with emerging treatment paradigms.

scholarly journals MicroRNA and mRNA Features of Malignant Pleural Mesothelioma and Benign Asbestos-Related Pleural Effusion

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Guntulu Ak ◽  
Sandra C. Tomaszek ◽  
Farhad Kosari ◽  
Muzaffer Metintas ◽  
James R. Jett ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Malignant Pleural Mesothelioma ◽  
Expression Profiling ◽  
Notch Signaling Pathway ◽  
Benign Disease ◽  
Pleural Mesothelioma ◽  
Diagnostic Utility ◽  
High Incidence ◽  
Fresh Frozen ◽  
Overexpressed Gene

Introduction. We investigated the expression of microRNAs and mRNAs in pleural tissues from patients with either malignant pleural mesothelioma or benign asbestos-related pleural effusion.Methods. Fresh frozen tissues from a total of 18 malignant pleural mesothelioma and 6 benign asbestos-related pleural effusion patients were studied. Expression profiling of mRNA and microRNA was performed using standard protocols.Results. We discovered significant upregulation of multiple microRNAs in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Hsa-miR-484, hsa-miR-320, hsa-let-7a, and hsa-miR-125a-5p were able to discriminate malignant from benign disease. Dynamically regulated mRNAs were also identified. MET was the most highly overexpressed gene in malignant pleural mesothelioma compared to benign asbestos-related pleural effusion. Integrated analyses examining microRNA-mRNA interactions suggested multiple altered targets within the Notch signaling pathway.Conclusions. Specific microRNAs and mRNAs may have diagnostic utility in differentiating patients with malignant pleural mesothelioma from benign asbestos-related pleural effusion. These studies may be particularly helpful in patients who reside in a region with a high incidence of mesothelioma.

Unusually High Incidence of Malignant Pleural Mesothelioma in a Town of Eastern Sicily: An Epidemiological and Environmental Study

2000 ◽  
Vol 55 (6) ◽  
pp. 392-398 ◽  
Author(s):  
Luigi Paoletti ◽  
Domenico Batisti ◽  
Caterina Bruno ◽  
Maurizio Di Paola ◽  
Antonio Gianfagna ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Environmental Study ◽  
Pleural Mesothelioma ◽  
High Incidence

scholarly journals Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

2020 ◽  
Author(s):  
Dearbhaile Catherine Collins ◽  
Raghav Sundar ◽  
Anastasia Constantidinou ◽  
David Dolling ◽  
Timothy Anthony Yap ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Metastatic Disease ◽  
Distant Metastases ◽  
Peritoneal Metastases ◽  
Pleural Mesothelioma ◽  
Clinical Workflow ◽  
Distant Metastatic Disease ◽  
High Incidence ◽  
Trial Protocols ◽  
Metastatic Sites

Abstract Background Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking. Methods In this retrospective study, we reviewed a cohort of 164 MPM patients referred to a Phase I trials unit, describe identified metastatic sites, and correlate with clinical outcomes. Results 67% of patients were diagnosed with distant metastatic disease with a high incidence of bone (19%), visceral (14%), contralateral lung (35%) and peritoneal metastases (22%). Peritoneal metastases were more likely in epithelioid versus biphasic/ sarcomatoid MPM (p = 0.015). Overall survival was 23.8 months with no statistical difference in survival between those with distant metastases and those without. Conclusions This report highlights the frequency of distant metastases and encourages further radiological investigations in the presence of symptoms. In particular, given the relatively high incidence of bone metastases, bone imaging should be considered in advanced MPM clinical workflow and trial protocols. The presence of distant metastases does not appear to have prognostic implications under existing treatment paradigms. This cohort of MPM patients gives an indication of patterns of metastatic spread that are likely to become prevalent as prognosis improves with emerging treatment paradigms.

scholarly journals Radiological evaluation of malignant pleural mesothelioma - defining distant metastatic disease

2020 ◽  
Author(s):  
Dearbhaile Catherine Collins ◽  
Raghav Sundar ◽  
Anastasia Constantidinou ◽  
David Dolling ◽  
Timothy Anthony Yap ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Metastatic Disease ◽  
Distant Metastases ◽  
Peritoneal Metastases ◽  
Pleural Mesothelioma ◽  
Clinical Workflow ◽  
Distant Metastatic Disease ◽  
High Incidence ◽  
Trial Protocols ◽  
Metastatic Sites

Abstract BackgroundMalignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking.MethodsIn this retrospective study, we reviewed a cohort of 164 MPM patients referred to a Phase I trials unit, aiming to describe identified metastatic sites, and correlate with clinical outcomes. Results67% of patients were diagnosed with distant metastatic disease with a high incidence of bone (19%), visceral (14%), contralateral lung (35%) and peritoneal metastases (22%). Peritoneal metastases were more likely in epithelioid versus biphasic/ sarcomatoid MPM (p=0.015). Overall survival was 23.8 months with no statistical difference in survival between those with distant metastases and those without.ConclusionsThis report highlights the frequency of distant metastases and encourages further radiological investigations in the presence of symptoms. In particular, given the relatively high incidence of bone metastases, bone imaging should be considered in advanced MPM clinical workflow and trial protocols. The presence of distant metastases does not appear to have prognostic implications under existing treatment paradigms. This cohort of MPM patients gives an indication of patterns of metastatic spread that are likely to become prevalent as prognosis improves with emerging treatment paradigms.

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