Poor nutritional status negatively influences prognosis of malignant pleural mesothelioma patients undergoing multimodal therapy

2019 ◽  
Author(s):  
O Lauk ◽  
M Hashimoto ◽  
U Held ◽  
M Friess ◽  
W Weder ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Malignant Pleural Mesothelioma ◽  
Multimodal Therapy ◽  
Pleural Mesothelioma ◽  
Poor Nutritional Status

scholarly journals Multimodal therapy of malignant pleural mesothelioma: is the replacement of radical surgery imminent?

2012 ◽  
Vol 16 (3) ◽  
pp. 237-243 ◽  
Author(s):  
J. Lindenmann ◽  
V. Matzi ◽  
N. Neuboeck ◽  
U. Anegg ◽  
A. Maier ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Multimodal Therapy ◽  
Radical Surgery ◽  
Pleural Mesothelioma

Malignant Mesothelioma: Has Anything Changed?

2019 ◽  
Vol 40 (03) ◽  
pp. 347-360 ◽  
Author(s):  
Roger Y. Kim ◽  
Daniel H. Sterman ◽  
Andrew R. Haas
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Multimodal Therapy ◽  
Asbestos Exposure ◽  
Treatment Options ◽  
Standard Of Care ◽  
Turn Of The Century ◽  
Clinical Approach ◽  
Pleural Mesothelioma ◽  
Dismal Prognosis ◽  
Near Future

AbstractMalignant pleural mesothelioma is a rare cancer associated with asbestos exposure and portends a dismal prognosis. Its worldwide incidence has been increasing, and treatment options are currently suboptimal and noncurative. However, since the turn of the century, several encouraging steps have been made toward improving outcomes for mesothelioma patients. An increased understanding of disease pathophysiology has led to more accurate diagnosis and staging, and the establishment of the standard of care first-line pemetrexed/platin doublet chemotherapy regimen in 2003 initially revolutionized treatment. While significant debate remains regarding the preferred approach to surgical and radiation therapy in the context of multimodal therapy, recent breakthroughs in immunotherapy offer hope for another paradigm shift in the near future. This review will summarize the current clinical approach to diagnosis, staging, and treatment of malignant pleural mesothelioma.

Hyperthermic intraoperative intrapleural chemotherapy and surgical cytoreduction as part of multimodal treatment of malignant pleural mesothelioma – case report

2020 ◽  
Vol 99 (10) ◽  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Cytoreductive Surgery ◽  
Multimodal Treatment ◽  
Multimodal Therapy ◽  
University Hospital ◽  
Extrapleural Pneumonectomy ◽  
Pleural Mesothelioma ◽  
Therapeutic Modalities ◽  
Hyperthermic Chemotherapy ◽  
Intrapleural Chemotherapy

Malignant pleural mesothelioma is one of the most aggressive malignancies with a very poor prognosis. Multimodal treatment consisting of three modalities – chemotherapy, radiotherapy and cytoreductive surgery is optimal. The use of new therapeutic modalities, such as hyperthermic intraoperative intrapleural chemotherapy or photodynamic therapy can improve the current results of mesothelioma treatment. Combined hyperthermic intraoperative chemotherapy and cytoreductive surgery as part of multimodal therapy of malignant mesothelioma has been used since 2017 at the 1st Department of Surgery of University Hospital Olomouc. The authors report the case of a 47-year-old man with malignant epithelioid mesothelioma of the left pleural cavity. Following neoadjuvant chemotherapy, this patient underwent extrapleural pneumonectomy with intraoperative intracavitary hyperthermic chemotherapy. The postoperative period was complicated by circulatory instability and later by tension fluidothorax with signs of heart failure. Currently, 8 months have elapsed from the surgery and the patient remains without any signs of recurrence.

Body composition and nutritional status in malignant pleural mesothelioma: implications for activity levels and quality of life

2019 ◽  
Vol 73 (10) ◽  
pp. 1412-1421
Author(s):  
Emily Jeffery ◽  
Y. C. Gary Lee ◽  
Robert U. Newton ◽  
Philippa Lyons-Wall ◽  
Joanne McVeigh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Composition ◽  
Nutritional Status ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Activity Levels
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