Acid Output on Histamine-Infusion Test in Duodenal Ulcer Patients

Digestion ◽  
1968 ◽  
Vol 1 (2) ◽  
pp. 115-119
Author(s):  
H.G. Desai ◽  
A.V. Borkar ◽  
K.N. Jeejeebhoy
Keyword(s):  
Duodenal Ulcer ◽  
Acid Output ◽  
Infusion Test

A Study of the Acid Dose-Response Curve to Small Doses of Pentagastrin in Duodenal Ulcer Patients

1972 ◽  
Vol 43 (2) ◽  
pp. 181-191
Author(s):  
J. B. Elder ◽  
G. Gillespie ◽  
E. H. G. Campbell ◽  
I. E. Gillespie ◽  
G. P. Crean ◽  
...  
Keyword(s):  
Duodenal Ulcer ◽  
Body Weight ◽  
Dose Response ◽  
Response Curve ◽  
Acid Output ◽  
Twilight Zone ◽  
Response Curves ◽  
Small Doses ◽  
Threshold Doses ◽  
Body Weight Dose

1. The acid secretory responses to a range of small doses of pentagastrin in 0·15 m-NaCl have been studied in thirty-one preoperative duodenal ulcer subjects. Acid output increased significantly above basal values when a dose of 0·064 μg h−1 kg−1 was given. 2. Control observations in sixteen duodenal ulcer patients using the saline solvent alone at identical rates of infusion showed no significant increase in acid output. 3. From the dose-response curves sub-threshold and threshold doses of pentapeptide are suggested for duodenal ulcer patients before truncal vagotomy. 4. Considerable variation in acid response was noted between patients given the same body-weight dose of pentapeptide. The results suggest that a ‘twilight zone’ of stimulation exists between the dose of pentagastrin by which few patients are stimulated and the dose by which the majority are stimulated. This may reflect some variation in the sensitivity to stimulation by pentagastrin from one patient to another.

The Relation between Functioning Parietal Cell and Gastrin Cell Masses in Two Groups of Duodenal Ulcer Patients

1976 ◽  
Vol 50 (5) ◽  
pp. 375-383 ◽  
Author(s):  
D. J. Byrnes ◽  
Shiu Kum Lam ◽  
W. Sircus
Keyword(s):  
Duodenal Ulcer ◽  
Parietal Cell ◽  
Serum Gastrin ◽  
Acid Output ◽  
Ulcer Patient ◽  
Cell Mass ◽  
Inverse Correlation ◽  
Normal Subjects ◽  
Gastrin Cell ◽  
Before And After

1. Serum gastrin concentrations before and after a standardized meal were determined in twenty-eight patients with duodenal ulcer and in ten normal control subjects. 2. In response to pentagastrin, thirteen of the duodenal ulcer subjects secreted acid within the limits of normal and fifteen secreted in excess. 3. The differences in the basal serum gastrin concentrations between the three groups, normal subjects, acid ‘normosecretors’ and hypersecretors were not statistically significant but that of the hypersecretors was suggestively low. 4. The integrated gastrin response and peak gastrin responses to meals were higher in duodenal ulcer patients with normal acid secretion than in the hypersecretors but the values for the latter were not different from normal subjects. 5. Stabilization of intragastric pH by infusion into the antrum of sodium bicarbonate during the test meal response period did not alter these differences between the two ulcer patient groups. 6. A significant inverse correlation exists between the maximal acid output and the integrated gastrin response in both normal subjects and hypersecreting duodenal ulcer patients. 7. The evidence (a) supports the existence of an inverse relationship between the functioning parietal cell and gastrin cell masses, (b) shows the gastrin response in normosecreting ulcer subjects to be inappropriately high, and (c) suggests that excessive vagotonia exerts trophic effects upon both parietal cell mass and gastrin cell mass.

Gastric acid output, bacterial load and gastritis in Helicobacter pylori positive patients with duodenal ulcer

1995 ◽  
Vol 108 (4) ◽  
pp. A147
Author(s):  
PH Le Roux ◽  
AW Harris ◽  
MM Walker ◽  
JJ Misiewicz ◽  
JH Baron
Keyword(s):  
Duodenal Ulcer ◽  
Helicobacter Pylori ◽  
Gastric Acid ◽  
Acid Output ◽  
Bacterial Load ◽  
Gastric Acid Output

Acupuncture and Gastric Acid Studies

1979 ◽  
Vol 07 (04) ◽  
pp. 356-361 ◽  
Author(s):  
Joseph O. A. Sodipo ◽  
J. M. Falaiye
Keyword(s):  
Duodenal Ulcer ◽  
Pain Relief ◽  
Gastric Acid ◽  
Acid Output ◽  
Symptomatic Relief ◽  
Ulcer Group ◽  
History Of ◽  
Basal Acid ◽  
The Mean ◽  
The Difference

The effects of therapeutic acupuncture on gastric acid secretion on pain relief in chronic duodenal ulcer patients were studied. Ten adult Nigerian patients with clinical, endoscopic as well as radiological evidence of duodenal ulcer constituted the "Ulcer Group". Four other patients who gave history of dyspepsia formed the "Dyspeptic Group". Pentagastrin stimulation test was performed on all subjects pre- and post-acupuncture therapy. The classical Chinese acupuncture loci were employed. The mean Basal Acid Output (BAO) in the duodenal ulcer group was markedly reduced from 4.04 ±1.01 mMols/hour to 1.05±2.5mMols/hour. The mean Maximal Acid Output (MAO) was lowered from 34.72±13.81 mMols/hour to 15.34±4.01 mMols/hour. The difference was statistically significant (P<0.001). It is more probable, therefore, that the relief of pain is attributable to the therapeutic inhibition of gastric hyperacidity in our patients. Thus, though pain relief has been previously demonstrated in response to acupuncture, the results of this investigation have gone further to show that acupuncture achieves symptomatic relief through therapeutic gastric depression in duodenal ulcer patients.

scholarly journals Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development

2010 ◽  
Vol 59 (12) ◽  
pp. 1484-1489 ◽  
Author(s):  
Shinobu Imagawa ◽  
Masanori Ito ◽  
Masaharu Yoshihara ◽  
Hidetaka Eguchi ◽  
Shinji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Rank Test ◽  
Peptic Ulcers ◽  
Log Rank Test ◽  
H Pylori

Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1–30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated Helicobacter pylori duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P<0.05). dupA-positive H. pylori was detected not only in DU patients (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity in patients with dupA-positive H. pylori than in those with dupA-negative H. pylori (P<0.05). The occurrence of GCa was significantly lower in patients with dupA-positive H. pylori and a high BAO level (log-rank test P<0.05). DUs, higher acid output and dupA-positive H. pylori were negatively associated with GCa.

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