A Controlled Trial of Recombinant Interferon-Alpha in Caucasian Children with Chronic Hepatitis B

Digestion ◽  
1990 ◽  
Vol 45 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Mercedes Ruiz Moreno ◽  
Jesus Jimenez ◽  
Juan Carlos Porres ◽  
Javier Bartolomé ◽  
Alberto Moreno ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Alpha ◽  
Controlled Trial ◽  
Recombinant Interferon ◽  
Recombinant Interferon Alpha

scholarly journals A Multicentre Randomized Controlled Trial of Recombinant Interferon-Alpha-2a in the Treatment of Patients with Chronic Hepatitis C

1997 ◽  
Vol 11 (7) ◽  
pp. 579-582 ◽  
Author(s):  
Masafumi Komatsu ◽  
Tsuyoshi Ono ◽  
Ko Nakajima ◽  
Itaru Toyoshima ◽  
Mitsuro Chiba ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Alpha ◽  
Dose Group ◽  
Controlled Trial ◽  
Complete Response ◽  
High Dose ◽  
Recombinant Interferon ◽  
Recombinant Interferon Alpha

Sixty-one chronic hepatitis C patients were randomly assigned to receive either 6x106or 9x106U of recombinant interferon-alpha-2a (IFNα-2a) six days a week for the first two weeks of treatment, followed in both cases by 6x106U three days a week for the next 22 weeks. In the low dose group, 11 patients showed a complete response maintained for at least six months, 12 responded but then relapsed and nine did not respond; the corresponding figures in the high dose group were 10, 15 and five patients, respectively. The differences between groups are not statistically significant. Thus, this study provides no evidence of therapeutic benefit from increasing the initial dose of IFNα-2a. In both treatment groups, complete responders had significantly lower pretreatment viral titres than nonresponders and were significantly more likely to be infected by type 2a versus type 1b virus.

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