Normal Values of 24-Hour Combined Esophageal Multichannel Intraluminal Impedance and pH Monitoring in the Chinese Population

Objective To review the current literature about the epidemiology, clinical presentation, diagnosis, and treatment of laryngopharyngeal reflux (LPR). Data Sources PubMed, Cochrane Library, and Scopus. Methods A comprehensive review of the literature on LPR epidemiology, clinical presentation, diagnosis, and treatment was conducted. Using the PRISMA statement, 3 authors selected relevant publications to provide a critical analysis of the literature. Conclusions The important heterogeneity across studies in LPR diagnosis continues to make it difficult to summarize a single body of thought. Controversies persist concerning epidemiology, clinical presentation, diagnosis, and treatment. No recent epidemiologic study exists regarding prevalence and incidence with the use of objective diagnostic tools. There is no survey that evaluates the prevalence of symptoms and signs on a large number of patients with confirmed LPR. Regarding diagnosis, an increasing number of authors used multichannel intraluminal impedance–pH monitoring, although there is no consensus regarding standardization of the diagnostic criteria. The efficiency of proton pump inhibitor (PPI) therapy remains poorly demonstrated and misevaluated by incomplete clinical tools that do not take into consideration many symptoms and extralaryngeal findings. Despite the recent advances in knowledge about nonacid LPR, treatment protocols based on PPIs do not seem to have evolved. Implications for Practice The development of multichannel intraluminal impedance–pH monitoring and pepsin and bile salt detection should be considered for the establishment of a multiparameter diagnostic approach. LPR treatment should evolve to a more personalized regimen, including diet, PPIs, alginate, and magaldrate according to individual patient characteristics. Multicenter international studies with a standardized protocol could improve scientific knowledge about LPR.

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Multichannel intraluminal impedance and esophageal manometry data for unrestricted swallowing: establishing normal values

Diseases of the Esophagus ◽

10.1111/j.1442-2050.2007.00747.x ◽

2008 ◽

Vol 21 (1) ◽

pp. 51-56 ◽

Cited By ~ 6

Author(s):

J. A. Wilson ◽

I. Mainie ◽

R. Tutuian ◽

A. Agrawal ◽

D. O. Castell

Keyword(s):

Esophageal Manometry ◽

Normal Values ◽

Multichannel Intraluminal Impedance ◽

Intraluminal Impedance

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The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children

Pediatrics & Neonatology ◽

10.1016/j.pedneo.2015.09.008 ◽

2016 ◽

Vol 57 (5) ◽

pp. 385-389 ◽

Cited By ~ 10

Author(s):

Yu-Wen Liu ◽

Jia-Feng Wu ◽

Huey-Ling Chen ◽

Hong-Yuan Hsu ◽

Mei-Hwei Chang ◽

...

Keyword(s):

Reflux Esophagitis ◽

Ph Monitoring ◽

Multichannel Intraluminal Impedance ◽

Intraluminal Impedance ◽

Multichannel Intraluminal Impedance Ph

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COMBINED 24-HOURS ESOPHAGEAL PH MONITORING AND MULTICHANNEL INTRALUMINAL IMPEDANCE FOR COMPARISON OF GASTROESOPHAGEAL REFLUX IN CHILDREN WITH TYPICAL VERSUS ATYPICAL SYMPTOMS OF GASTROESOPHAGEAL REFLUX DISEASE

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032016000300002 ◽

2016 ◽

Vol 53 (3) ◽

pp. 130-135 ◽

Cited By ~ 1

Author(s):

Seyed Mohsen DEHGHANI ◽

Seyed Alireza TAGHAVI ◽

Hazhir JAVAHERIZADEH ◽

Maryam NASRI

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Reflux Disease ◽

Ph Monitoring ◽

P Value ◽

Multichannel Intraluminal Impedance ◽

Symptom Index ◽

Atypical Symptoms ◽

Intraluminal Impedance ◽

The Mean

ABSTRACT Background - Gastroesophageal reflux disease is the most common esophageal disorder in pediatrics. Objective - The aim of this study was to compare reflux parameters of typical and atypical symptoms of gastroesophageal reflux disease using 24-hour esophageal pH monitoring and multichannel intraluminal impedance in pediatric population. Methods - In this prospective study, 43 patients aged less than 18 year with suspected gastroesophageal reflux disease were enrolled. The patients were divided into two groups based on the main presenting symptoms (typical versus atypical). Twenty four-hour pH monitoring and multichannel intraluminal impedance were performed in all the patients for comparing these two group regarding association of symptoms and reflux. Number of refluxes, pH related reflux, total reflux time, reflux more than 5 minutes, longest time of the reflux, lowest pH at reflux, reflux index were recorded and compared. Data comparison was done using SPSS. Results - The mean age of the patients was 5.7±3.4 years and 65.1% were male. Out of 43 patients 24 cases had typical symptoms and 19 had atypical symptoms. The mean reflux events detected by multichannel intraluminal impedance was more than mean reflux events detected by pH monitoring (308.4±115.8 vs 69.7±66.6) with P value of 0.037, which is statistically significant. The mean symptom index and symptom association probability were 35.01% ± 20.78% and 86.42% ± 25.79%, respectively in multichannel intraluminal impedance versus 12.73% ± 12.48% and 45.16% ± 42.29% in pH monitoring (P value <0.001). Number of acid reflux was 46.26±47.16 and 30.9±22.09 for atypical and typical symptoms respectively. The mean symptom index was 18.12% ± 13.101% and 8.30% ± 10.301% in atypical and typical symptoms respectively (P=0.034). Bolus clearance was longer in atypical symptoms compared typical symptoms(P<0.05). Conclusion - Symptom index was significantly higher in atypical symptoms compared to typical symptoms. Higher number of acid reflux was found in children with atypical symptoms of reflux. Longer duration of bolus clearance was found in group with atypical symptoms of reflux.

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