A Simpler Method for Combined Detection of Human Peripheral Lymphocyte Subpopulations

1979 ◽  
Vol 59 (1) ◽  
pp. 114-116
Author(s):  
Y. Lee ◽  
Y. Yoshizawa ◽  
R.G. Carr ◽  
M.M. Yokoyama
Keyword(s):  
Peripheral Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
Combined Detection ◽  
Human Peripheral Lymphocyte ◽  
Simpler Method

Characterization of culture-induced cytotoxicity from human peripheral lymphocyte subpopulations

1986 ◽  
Vol 97 (2) ◽  
pp. 307-315
Author(s):  
James J. Rusthoven ◽  
David Osoba
Keyword(s):  
Peripheral Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
Human Peripheral Lymphocyte

Spindle-Inhibiting Effects of Organotin Compounds: Effects of Trimethyltin on Chromosome Length

1990 ◽  
Vol 17 (3) ◽  
pp. 195-198
Author(s):  
Klaus Gjervig Jensen ◽  
Ole Andersen ◽  
Mogens Rønne
Keyword(s):  
Exposure Time ◽  
Industrial Applications ◽  
Chromosome Length ◽  
Peripheral Lymphocyte ◽  
Organotin Compounds ◽  
Lymphocyte Cultures ◽  
Trimethyltin Chloride ◽  
Industrial Settings ◽  
Spindle Function ◽  
Human Peripheral Lymphocyte

Organotin compounds have a number of industrial applications, and human exposures occur in various industrial settings. The present study reports effects of trimethyltin chloride (TMT) on chromosome length in asynchronous human peripheral lymphocyte cultures. The results demonstrate dose-related and exposure time-related reductions in average chromosome length. Induction of supercontraction indicates that TMT is a powerful inhibitor of spindle function. TMT would thus be expected to be able to induce aneuploidy due to non-disjunction. This study indicates the need for more-direct investigations on the spindle-inhibiting effects of TMT and other organotin compounds.

scholarly journals High-resolution analysis of human peripheral lymphocyte chromosomes by flow cytometry.

1981 ◽  
Vol 78 (12) ◽  
pp. 7727-7731 ◽  
Author(s):  
B. D. Young ◽  
M. A. Ferguson-Smith ◽  
R. Sillar ◽  
E. Boyd
Keyword(s):  
Flow Cytometry ◽  
High Resolution ◽  
Peripheral Lymphocyte ◽  
High Resolution Analysis ◽  
Resolution Analysis ◽  
Human Peripheral Lymphocyte

MITOGENIC FRACTIONS IN HUMAN PERIPHERAL LYMPHOCYTE EXTRACTS

The Lancet ◽  
1964 ◽  
Vol 283 (7326) ◽  
pp. 201-202 ◽  
Author(s):  
Nemat Hashem ◽  
FredS. Rosen
Keyword(s):  
Peripheral Lymphocyte ◽  
Human Peripheral Lymphocyte

Applications of immunohistochemistry in the evaluation of immunosuppressive agents

2000 ◽  
Vol 19 (4) ◽  
pp. 251-254 ◽  
Author(s):  
N A Gillett ◽  
C Chan
Keyword(s):  
Immune Function ◽  
Tissue Distribution ◽  
Clinical Significance ◽  
Peripheral Blood ◽  
Immunosuppressive Agents ◽  
Flow Cytometric Analysis ◽  
Peripheral Lymphocyte ◽  
Lymphocyte Subpopulations ◽  
Flow Cytometric ◽  
Conventional Histology

Immunohistochemistry (IHC) can be a valuable endpoint to evaluate lymphocyte subpopulations in tissues following exposure to presumptive immunosuppressive agents. IHC is more sensitive than conventional histology in detecting subtle differences in lymphocyte numbers and distribution in tissue. In combination with flow cytometric analysis of peripheral lymphocyte subpopulations, IHC can determine if alterations detected in the peripheral blood are a result of trafficking or reflective of changes in tissue distribution. These techniques can be used to evaluate adult animals as well as to evaluate the effects of immunosuppressive agents on fetal tissues in reproductive toxicology studies. While IHC can enhance the detection of subtle changes in lymphocyte subpopulations in tissue, the evaluation of additional end-points of immune function must be done to further assess the biological or clinical significance ofthese changes.

Effects of denosumab on peripheral lymphocyte subpopulations

Endocrine ◽  
2015 ◽  
Vol 53 (3) ◽  
pp. 857-859 ◽  
Author(s):  
Maurizio Rossini ◽  
Ombretta Viapiana ◽  
Silvano Adami ◽  
Luca Idolazzi ◽  
Francesco Ghellere ◽  
...  
Keyword(s):  
Peripheral Lymphocyte ◽  
Lymphocyte Subpopulations
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