Umbilical Cord Blood Histamine Levels in Newborn Infants with and without Perinatal Anoxia

Neonatology ◽  
1970 ◽  
Vol 15 (5-6) ◽  
pp. 300-303
Author(s):  
J.F. Porter ◽  
J.A. Young ◽  
S. Rasheed
1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.


1994 ◽  
Vol 36 (6) ◽  
pp. 799-804 ◽  
Author(s):  
Christoph Bührer ◽  
Johannes Graulich ◽  
Dietger Stibenz ◽  
Joachim W Dudenhausen ◽  
Michael Obladen

2008 ◽  
Vol 198 (1) ◽  
pp. 43.e1-43.e5 ◽  
Author(s):  
Robert L. Goldenberg ◽  
William W. Andrews ◽  
Alice R. Goepfert ◽  
Ona Faye-Petersen ◽  
Suzanne P. Cliver ◽  
...  

2009 ◽  
Vol 16 (3) ◽  
pp. 119-123 ◽  
Author(s):  
M Abduljabbar ◽  
A Al Shahri ◽  
A Afifi

Objective To assess the performance of the use of umbilical cord blood for screening of primary congenital hypothyroidism in the Saudi Aramco Medical Services Organization newborn thyroid screening programme. Methods Umbilical cord blood total thyroxin (CB-TT4) was measured. In samples with low T4 concentrations, an additional measurement of cord blood thyroid-stimulating hormone was made. Results A total of 96,015 newborn infants were screened in the period January 1990-December 2007. Twenty-six cases of primary congenital hypothyroidism, six cases of transient hypothyroidism and 13 cases of central hypothyroidism were detected. This method of screening resulted in 100% sensitivity and 98% specificity (95% CI 84–100, and 95% CI 98–98.2, respectively). However, there was a high mean recall rate of 1.9%. Conclusion The use of CB-TT4 is a valid screening strategy for primary congenital hypothyroidism. It meets the metabolic screening demands of early discharge policy and guarantees screening all newborns delivered in the hospital.


1989 ◽  
Vol 26 (2) ◽  
pp. 106-108 ◽  
Author(s):  
Lars Irestedt ◽  
Ingrid Dahlin ◽  
Torbjörn Hertzberg ◽  
Alf Sollevi ◽  
Hugo Lagercrantz

1966 ◽  
Vol 52 (1) ◽  
pp. 154-167 ◽  
Author(s):  
Kai R. Jorgensen ◽  
Torsten Deckert ◽  
L. Mølsted Pedersen ◽  
Jørgen Pedersen

ABSTRACT The venous plasma insulin and glucose concentration was investigated in 15 diabetic and 13 non-diabetic women at birth; in the umbilical cord blood of their infants at birth; 1.5 to 6 hours after birth in the fasting state; and 5 and 30 minutes after a glucose load injected through a catheter inserted in the umbilical vein. Insulin antibodies were estimated at birth. Antibodies were found in the maternal and the umbilical cord blood in 13 diabetic mothers who had had insulin treatment for 2–20 years, but not in 2 diabetics with, respectively, no insulin treatment, and treatment for a few days only. In infants of non-diabetic mothers, the insulin concentration at birth was lower than that of their mothers. In infants of diabetic women the insulin concentration was much higher than that of the control infants. After glucose injection a rapid increase of the insulin concentration in the umbilical vein was demonstrated in infants of diabetic women, whereas the rise was slow in infants of non-diabetics, thus indicating a greater reactivity of insulin secretion or release in infants of diabetic women. After glucose injection, the plasma glucose concentration in the umbilical vein rose and fell rapidly without any difference being found between the two groups, in contrast to the great differences in their insulin concentration.


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