scholarly journals The Alabama Preterm Birth Study: Umbilical cord blood Ureaplasma urealyticum and Mycoplasma hominis cultures in very preterm newborn infants

2008 ◽  
Vol 198 (1) ◽  
pp. 43.e1-43.e5 ◽  
Author(s):  
Robert L. Goldenberg ◽  
William W. Andrews ◽  
Alice R. Goepfert ◽  
Ona Faye-Petersen ◽  
Suzanne P. Cliver ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Ureaplasma Urealyticum ◽  
Newborn Infants ◽  
Mycoplasma Hominis ◽  
Preterm Newborn ◽  
Very Preterm

Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta
Keyword(s):  
Oxygen Consumption ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Newborn Infant ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
O2 Consumption ◽  
Adult Control ◽  
Healthy Newborn ◽  
Before And After

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

scholarly journals RNA-Sequencing of Umbilical Cord Blood to Investigate Spontaneous Preterm Birth: A Pilot Study

2019 ◽  
Vol 09 (01) ◽  
pp. e60-e66
Author(s):  
Neeta Vora ◽  
Joel Parker ◽  
Piotr Mieckowski ◽  
Lisa Smeester ◽  
Rebecca Fry ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Preterm Birth ◽  
Pilot Study ◽  
Cord Blood ◽  
Rna Sequencing ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Significant Differential Expression ◽  
Metabolism Gene

Objective To analyze the transcriptomic gene expression of umbilical cord blood leukocytes using RNA-sequencing from preterm birth (PTB) and term birth (TB). Study Design Eight women with spontaneous PTB (sPTB) and eight women with unlabored TB were enrolled prospectively. The sPTB and TB cohorts were matched for maternal age, race, mode of delivery, and fetal sex. Cord blood RNA was extracted and a globin depletion protocol was applied, then sequenced on the Illumina HiSeq 4000. Raw read counts were analyzed with DESeq2 to test for gene expression differences between sPTB and TB. Results 148 genes had significant differential expression (q < 0.01). Cell cycle/metabolism gene expression was significantly higher and immune/inflammatory signaling gene expression significantly lower in the sPTB cohort compared with term. In African American (AA) infants, 18 genes specific to cell signaling, neutrophil activity, and major histocompatibility complex type 1 had lower expression in preterm compared with term cohort; the opposite pattern was seen in non-Hispanic Whites (NHWs). Conclusion Compared with term, preterm fetuses have higher cell cycle/metabolism gene expression, suggesting metabolic focus on growth and development. Immune function gene expression in this pilot study is lower in the sPTB group compared with term and differs in AA compared with NHW infants.

Umbilical Cord Blood Histamine Levels in Newborn Infants with and without Perinatal Anoxia

Neonatology ◽  
1970 ◽  
Vol 15 (5-6) ◽  
pp. 300-303
Author(s):  
J.F. Porter ◽  
J.A. Young ◽  
S. Rasheed
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
Blood Histamine

scholarly journals L-Selectin Is Down-regulated in Umbilical Cord Blood Granulocytes and Monocytes of Newborn Infants with Acute Bacterial Infection

1994 ◽  
Vol 36 (6) ◽  
pp. 799-804 ◽  
Author(s):  
Christoph Bührer ◽  
Johannes Graulich ◽  
Dietger Stibenz ◽  
Joachim W Dudenhausen ◽  
Michael Obladen
Keyword(s):  
Bacterial Infection ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Newborn Infants

Is Umbilical Cord Blood Total Thyroxin Measurement Effective in Newborn Screening for Hypothyroidism?

2009 ◽  
Vol 16 (3) ◽  
pp. 119-123 ◽  
Author(s):  
M Abduljabbar ◽  
A Al Shahri ◽  
A Afifi
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Congenital Hypothyroidism ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
Early Discharge ◽  
Recall Rate ◽  
Thyroid Stimulating Hormone ◽  
Central Hypothyroidism ◽  
Discharge Policy

Objective To assess the performance of the use of umbilical cord blood for screening of primary congenital hypothyroidism in the Saudi Aramco Medical Services Organization newborn thyroid screening programme. Methods Umbilical cord blood total thyroxin (CB-TT4) was measured. In samples with low T4 concentrations, an additional measurement of cord blood thyroid-stimulating hormone was made. Results A total of 96,015 newborn infants were screened in the period January 1990-December 2007. Twenty-six cases of primary congenital hypothyroidism, six cases of transient hypothyroidism and 13 cases of central hypothyroidism were detected. This method of screening resulted in 100% sensitivity and 98% specificity (95% CI 84–100, and 95% CI 98–98.2, respectively). However, there was a high mean recall rate of 1.9%. Conclusion The use of CB-TT4 is a valid screening strategy for primary congenital hypothyroidism. It meets the metabolic screening demands of early discharge policy and guarantees screening all newborns delivered in the hospital.

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