Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

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The Value of Umbilical Cord Blood Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Newborn

Bangladesh Journal of Child Health ◽

10.3329/bjch.v33i2.5677 ◽

1970 ◽

Vol 33 (2) ◽

pp. 50-54 ◽

Cited By ~ 7

Author(s):

Zakia Nahar ◽

Md Shahidullah ◽

Abdul Mannan ◽

Sanjoy Kumar Dey ◽

Ujjal Mitra ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Predictive Value ◽

Newborn Infants ◽

Subsequent Development ◽

Total Serum ◽

Characteristic Analysis ◽

Healthy Newborn ◽

Group I

The present study was conducted to investigate the predictability of early serumbilirubin levels on the subsequent development of neonatal hyperbilirubinemia. Forthis purpose 84 healthy newborn infants were enrolled and followed up for first 5 daysof life. Study subjects were divided into two groups. Group-I consisted of 71 subjects,who did not develop significant hyperbilirubinemia (bilirubin <17mg/dl); Group-IIconsisted of 13 newborns, who developed significant hyperbilirubinemia (bilirubin >17mg/dl) during the follow up. Of the enrolled subjects, 46 (55%) were male and rest 38(45%) were female; 64 (76%) were term babies and 20 (24%) were pre-term babies.Significantly higher percentage of pre-term babies developed hyperbilirubinemia. ROC(receiver operating characteristic) analysis demonstrates that the critical value ofcord blood bilirubin >2.5mg/dl had the high sensitivity (77%) and specificity (98.6%)to predict the newborn who would develop significant hyperbilirubinemia. At this levelthe negative predictive value was 96% and positive predictive value 91%. In oursetting infants having umbilical cord blood total serum bilirubin (TSB) >2.5 mg/dlshould be followed up strictly either in hospital or as an outpatient department on day5 if practicable. Infants having TSB <2.5mg/dl in cord blood can be discharged early.Key words: Umbilical cord bilirubin; neonatal jaundice; healthy newborn.DOI: 10.3329/bjch.v33i2.5677Bangladesh Journal of Child Health 2009; Vol.33(2): 50-54

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HHV-6 Encephalitis in Pediatric Unrelated Umbilical Cord Blood Transplantation: Role for Ganciclovir Prophylaxis?

Blood ◽

10.1182/blood.v114.22.4667.4667 ◽

2009 ◽

Vol 114 (22) ◽

pp. 4667-4667

Author(s):

Frankie Wai Tsoi Cheng ◽

Vincent Lee ◽

Wing Kwan Leung ◽

Paul Kay Sheung Chan ◽

Ting Fan Leung ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Conflicts Of Interest ◽

Rare Complication ◽

Cord Blood Transplantation ◽

The Other ◽

Cell Transplant ◽

Hematopoietic Stem ◽

Before And After

Abstract Abstract 4667 Background The role of ganciclovir as HHV-6 prophylaxis in unrelated hematopoietic stem cell transplant (HSCT) setting remains controversial. Methods We performed a 8-year retrospective review of patients received unrelated HSCT from January 2000 to September 2008. From January 2002, ganciclovir prophylaxis 5mg/kg twice daily for 7 days for all unrelated HSCT before transplant was adopted. The other transplant policies including antibacterial, antifungal, antiviral and graft-versus-host disease control policies remained unchange in that period. The prevalence of HHV-6 encephalitis was studied before and after the change in policy. Result Fifty-four unrelated HSCT were performed from January, 2000 to September, 2008. Total four cases (7.4%) of HHV-6 encephalitis were diagnosed. Two cases out of 16 cases (12.5%) diagnosed before adoption of the policy; 2 cases out of 38 cases (5.3%) diagnosed afterward. All of them were unrelated umbilical cord blood (UCB) transplant recipients. Two cases had significant residual neurological deficit and refractory seizure. The other two cases died of other transplant-related mortalities. Conclusion We conclude that HHV-6 encephalitis is still a rare complication of unrelated HSCT and may be more common in unrelated UCB transplantation. Routine use of ganciclovir as HHV-6 prophylaxis in all unrelated HSCT recipients may not be justified. Disclosures: No relevant conflicts of interest to declare.

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