Studies on the Effect and Mode of Action of Flavoxate in Human Urinary Bladder and Sphincter

1977 ◽  
Vol 32 (2-3) ◽  
pp. 202-208 ◽  
Author(s):  
Ejner Pedersen
Keyword(s):  
Urinary Bladder ◽  
Mode Of Action ◽  
Human Urinary Bladder

scholarly journals Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary

2018 ◽  
Vol 7 (4) ◽  
pp. 565-575 ◽  
Author(s):  
Samuel M. Cohen
Keyword(s):  
Urinary Bladder ◽  
Dose Response ◽  
Mode Of Action ◽  
Direct Relevance ◽  
Human Urinary Bladder

Screening for carcinogens in general, and for the urinary bladder specifically, traditionally involves a two-year bioassay in rodents, the results of which often do not have direct relevance to humans with respect to mode of action (MOA) and/or dose response.

Eicosanoid Synthesis by Human Urinary Bladder Mucosa: Pathological Implications

1987 ◽  
Vol 59 (1) ◽  
pp. 36-39 ◽  
Author(s):  
J. Y. JEREMY ◽  
V. TSANG ◽  
D. P. MIKHAILIDIS ◽  
H. ROGERS ◽  
R. J. MORGAN ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bladder Mucosa ◽  
Eicosanoid Synthesis ◽  
Human Urinary Bladder

scholarly journals REACTIVITY OF MONOCLONAL ANTIBODIES TO HUMAN URINARY BLADDER CANCERS

1986 ◽  
Vol 77 (7) ◽  
pp. 1151-1158
Author(s):  
Isao Numata ◽  
Senji Hoshi ◽  
Kaoru Takahashi ◽  
Kazuyuki Yoshikawa ◽  
Tatsuo Tochigi ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Urinary Bladder ◽  
Human Urinary Bladder

scholarly journals Sodium Transport in the Toad Bladder

1971 ◽  
Vol 28 (5_suppl_2) ◽  
Author(s):  
HOWARD S. FRAZIER
Keyword(s):  
Urinary Bladder ◽  
Sodium Transport ◽  
Mode Of Action ◽  
Renal Tubule ◽  
Alternative Hypothesis ◽  
Toad Bladder ◽  
Second Step ◽  
Epithelial Layer ◽  
Granular Cells ◽  
Simple Alternative

The isolated urinary bladder of the toad transports sodium actively across its epithelial layer and responds to the hormones vasopressin and aldosterone, properties which make it a useful model for the study of certain functions of the renal tubule. Sodium transport in the granular cells of the bladder is thought to involve first an energetically passive but selective entry step at the mucosal surface, the rate of which is increased after vasopressin administration. The second step in transport is considered to be active extrusion of the ion across the serosal boundary of the cell. Recent evidence concerning the cellular pool of sodium and the site and mode of action of vasopressin suggests that this description is at best incomplete. No equally simple alternative hypothesis for the organization of sodium transport in this system is available at present.

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