The Effect of Retinal Ganglion Cell Injury on Light-Induced Photoreceptor Degeneration

2004 ◽  
Vol 45 (2) ◽  
pp. 685 ◽  
Author(s):  
Robert J. Casson ◽  
Glyn Chidlow ◽  
John P. M. Wood ◽  
Manuel Vidal-Sanz ◽  
Neville N. Osborne
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration

Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway

Gene ◽  
2020 ◽  
Vol 763 ◽  
pp. 145030
Author(s):  
Rui-Xue Sun ◽  
Zhao-Hui Sun ◽  
Qian Ren ◽  
Li Li ◽  
Li Yin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Ocular Hypertension ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion ◽  
P38mapk Pathway

scholarly journals Mechanisms of retinal ganglion cell injury and defense in glaucoma

2010 ◽  
Vol 91 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Juan Qu ◽  
Danyi Wang ◽  
Cynthia L. Grosskreutz
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion

scholarly journals Retinal Ganglion Cell Death as a Late Remodeling Effect of Photoreceptor Degeneration

2019 ◽  
Vol 20 (18) ◽  
pp. 4649 ◽  
Author(s):  
Diego García-Ayuso ◽  
Johnny Di Pierdomenico ◽  
Manuel Vidal-Sanz ◽  
María P. Villegas-Pérez
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration ◽  
Inner Retina ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death ◽  
Photoreceptor Degenerations

Inherited or acquired photoreceptor degenerations, one of the leading causes of irreversible blindness in the world, are a group of retinal disorders that initially affect rods and cones, situated in the outer retina. For many years it was assumed that these diseases did not spread to the inner retina. However, it is now known that photoreceptor loss leads to an unavoidable chain of events that cause neurovascular changes in the retina including migration of retinal pigment epithelium cells, formation of “subretinal vascular complexes”, vessel displacement, retinal ganglion cell (RGC) axonal strangulation by retinal vessels, axonal transport alteration and, ultimately, RGC death. These events are common to all photoreceptor degenerations regardless of the initial trigger and thus threaten the outcome of photoreceptor substitution as a therapeutic approach, because with a degenerating inner retina, the photoreceptor signal will not reach the brain. In conclusion, therapies should be applied early in the course of photoreceptor degeneration, before the remodeling process reaches the inner retina.

Mechanisms of Retinal Ganglion Cell Injury in Aging and Glaucoma

2010 ◽  
Vol 44 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Vicki Chrysostomou ◽  
Ian A. Trounce ◽  
Jonathan G. Crowston
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Retinal Ganglion

Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina

2015 ◽  
Vol 36 (4) ◽  
pp. 531-540 ◽  
Author(s):  
Chanjuan Zhang ◽  
Zhen Wang ◽  
Jiayi Zhao ◽  
Qin Li ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Injury ◽  
Neuroprotective Effect ◽  
Retinal Ganglion ◽  
Rat Retina

scholarly journals Retinal remodeling following photoreceptor degeneration causes retinal ganglion cell death

2018 ◽  
Vol 13 (11) ◽  
pp. 1885 ◽  
Author(s):  
Diego Garcia-Ayuso ◽  
Johnny Di Pierdomenico ◽  
Marta Agudo-Barriuso ◽  
Manuel Vidal-Sanz ◽  
MaríaP Villegas-Pérez
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration ◽  
Retinal Ganglion Cell Death ◽  
Retinal Remodeling ◽  
Ganglion Cell Death

Phototoxic-induced photoreceptor degeneration causes retinal ganglion cell degeneration in pigmented rats

2006 ◽  
Vol 498 (2) ◽  
pp. 163-179 ◽  
Author(s):  
Marco Antonio Marco-Gomariz ◽  
Natalia Hurtado-Montalbán ◽  
Manuel Vidal-Sanz ◽  
Ray D. Lund ◽  
María Paz Villegas-Pérez
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration ◽  
Cell Degeneration
Sign in / Sign up

Export Citation Format

Share Document