Metastatic Anaplastic Carcinoma of the Thyroid Mimicking Squamous Cell Carcinoma

2006 ◽  
Vol 50 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Maja H. Oktay ◽  
Matthew B. Smolkin ◽  
Mark Williams ◽  
Antonio Cajigas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Carcinoma

scholarly journals Aktivitas Antitumor Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme) secara In Vivo pada Mencit

2021 ◽  
Vol 22 (2) ◽  
pp. 150-161
Author(s):  
Ardi Sandriya ◽  
Bambang Pontjo Priosoeryanto ◽  
Gunanti Gunanti ◽  
Eva Harlina ◽  
Riski Rostantinata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Carcinoma

Penelitian ini bertujuan untuk mempelajari efektivitas ekstrak etanol daun keladi tikus (Typhonium flagelliforme) untuk terapi penyakit tumor. Penelitian ini menggunakan enam ekor mencit betina berumur lima minggu dengan bobot badan 20-25 g yang telah diinduksi karsinogen 7.12- dimetilbenz(?)anthracne (DMBA). Mencit dibagi menjadi dua kelompok perlakuan masing-masing kelompok terdiri dari tiga ekor mencit yaitu kelompok yang diberi plasebo (KK) dan kelompok yang diberi ekstrak etanol daun keladi tikus (KE). Kelompok KK diberi plasebo berupa aquabides. Kelompok KE diberi ekstrak etanol daun keladi tikus dengan dosis 120 mg/kg BB. Pengamatan dilakukan secara makroskopik dan mikroskopik. Massa tumor dari kedua kelompok mencit dikoleksi dan difiksasi dalam neutral buffered formalin (NBF) 10%. Kemudian dibuat preparat histopatologi dan diwarnai pewarna Hematoksilin-Eosin (HE). Hasil penelitian menunjukkan gambaran makroskopik permukaan kulit pada daerah tumbuhnya tumor mengalami alopesia, tumbuh benjolan berwarna kemerahan dan keropeng. Hasil pengukuran bobot badan mencit kelompok KK mengalami penurunan, sedangkan berat badan mencit pada kelompok KE mengalami kenaikan setiap minggunya. Diameter tumor kelompok KK mengalami peningkatan, sedangkan diameter tumor pada kelompok KE mengalami penurunan pada minggu ke empat pemberian bahan uji. Gambaran mikroskopik menunjukkan benjolan massa tumor yang terbentuk terdiri atas tiga jenis tumor yaitu anaplastic carcinoma (16,7%), fibrosarcoma (16,7%) dan squamous cell carcinoma (66,6%). Ketiga tumor digolongkan dalam diferensiasi baik 33,4%, diferensiasi sedang 33,4%, diferensiasi buruk 16,7%, dan tidak berdiferensiasi 16,.7%. Laju pertumbuhan tumor selaras dengan tingkat diferensiasi. Tumor yang bermetastasis sebanyak 50% dan tidak bermetastasis sebanyak 50%. Rataan indeks mitosis dan angiogenesis terjadi penurunan yang nyata (p<0.05) pada kelompok mencit yang diberi ekstrak etanol daun keladi tikus dibandingkan kelompok kontrol. Disimpulkan bahwa ekstrak etanol daun keladi tikus menurunkan pertumbuhan tumor dan dapat digunakan untuk terapi tumor.

scholarly journals On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

2021 ◽  
Author(s):  
Jian Huang ◽  
Xinle Ren ◽  
Hen Wang ◽  
Di Zhu ◽  
Jilin Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Carcinoma ◽  
Papillary Thyroid ◽  
Node Metastasis ◽  
Poorly Differentiated

Abstract Background: Thyroid squamous cell carcinoma is very rare. At present, it is limited to case reports. Since the thyroid follicular epithelium is the non-squamous epithelium, how primary squamous cell carcinoma(SCC) of the thyroid occurs is still a controversial issue. Hashimoto's thyroiditis(HT) is considered to be an independent risk factor for thyroid cancer, under the basis of HT, how tumor cells evolve and develop to papillary thyroid carcinoma(PTC), and particularly to de-differentiate into SCC is elusive.Patient: We report a 72-year-old female patient who developed multiple subtypes of PTC on a basis of HT, and finally to de-differentiate into SCC within the local foci of lymph node metastasis. Summary: We found that there was a variety of sub-types of PTC in this patient in the background of HT. SCC was found within local lymph node metastasis. Pathomorphology, immunohistochemistry, and molecular pathology have confirmed that SCC was derived from PTC, and then developed into poorly differentiated SCC and/or anaplastic carcinoma. We also conducted a comprehensive literature review.Conclusions: Thyroid SCC is derived from PTC and de-differentiated into poor differentiated SCC and/or anaplastic carcinoma, which is the result of the continuous evolution of PTC. It is suggested that the prognosis of the patient is very poor.

Undifferentiated (Anaplastic) Carcinoma and Squamous Cell Carcinoma of the Thyroid

2009 ◽  
pp. 139-151 ◽  
Author(s):  
Gregg A. Staerkel ◽  
Britt-Marie E. Ljung ◽  
Vinod Shidham ◽  
William J. Frable ◽  
Juan Rosai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Carcinoma

scholarly journals Primary Squamous Cell Carcinoma of the Thyroid Diagnosed as Anaplastic Carcinoma: Failure in Fine-Needle Aspiration Cytology?

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Fernanda Bolfi ◽  
Maria A. C. Domingues ◽  
Manuel Sobrinho-Simões ◽  
Paula Soares ◽  
Ricardo Celestino ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Hashimoto Thyroiditis ◽  
Final Diagnosis ◽  
Needle Aspiration ◽  
Anaplastic Carcinoma ◽  
Primary Squamous Cell Carcinoma ◽  
Needle Aspiration Cytology

A case of primary squamous-cell carcinoma (SCC) of the thyroid which had been initially diagnosed as an anaplastic carcinoma (ATC) is described: female, 73 years old, with a fast-growing cervical nodule on the left side and hoarseness for 3 months. Ultrasonography showed a 4.5 cm solid nodule. FNA was compatible with poorly differentiated carcinoma with immunoreactivity for AE1/AE3, EMA. Thyroidectomy was performed. Histopathological examination showed a nonencapsulated tumor. Immunohistochemistry disclosed positivity for AE1/AE3, p53,p63, and Ki67. The diagnosis was ATC. A second opinion reported tumor consisting of squamous cells, with intense inflammatory infiltrate both in tumor and in the adjacent thyroid, with final diagnosis of SCC, associated with Hashimoto thyroiditis. No other primary focus of SCC was found. Patient has shown a 48-month survival period. Clinically, primary SCCs of the thyroid and ATCs are similar. The distinction is often difficult particularly when based on the cytological analysis of FNA material.

Fibrinolysis in Solid Tumors

1979 ◽  
Author(s):  
P. Yuen ◽  
H.C. Kwaan ◽  
F. Ho
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Solid Tumors ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Fibrinolytic Activity ◽  
Biochemical Characterization ◽  
Malignant Tumors ◽  
Anaplastic Carcinoma ◽  
Cervix Uteri

The fibrinolytic activity of 120 malignant and 25 benign solid tumors from autopsy and biopsy specimens was studied by the fibrin slide technique as described by Kwaan and Astrup. The inhibitory activity against fibrinolysis was graded according to the Lysis time of vascuLar tissues within the tumor. The results show chat all malignant solid tumors, with the exception of carcinoma of prostate demonstrate varying degrees of inhibition of fibrinolysis. Persistently high inhibitory activity was found in squamous cell carcinoma of esophagus, the respiratory tract (including squamous cell carcinoma of sinuses, larynx and lung), cervix uteri and skin; carcinoma of uterus, colo-rectal carcinoma; small cell anaplastic carcinoma of lung; neuroblastoma; carcinoma of bile duct; while malignant tumors of the kidney show a lesser degree of inhibition. In contrast, with the exception of hydatldiform mole, benign solid tumors show-little or no Inhibition. There is a difference in fibrinolytic activity between the peripheral and the central portions of a tumor with distinctly greater degree of activity in the former. The pathophysiologic implications of the presence of such a strong inhibition of fibrinolysis is apparent. Biochemical characterization of this inhibition is currently in progress.

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