Fibrinolysis in Solid Tumors

1979 ◽  
Author(s):  
P. Yuen ◽  
H.C. Kwaan ◽  
F. Ho
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Solid Tumors ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Fibrinolytic Activity ◽  
Biochemical Characterization ◽  
Malignant Tumors ◽  
Anaplastic Carcinoma ◽  
Cervix Uteri

The fibrinolytic activity of 120 malignant and 25 benign solid tumors from autopsy and biopsy specimens was studied by the fibrin slide technique as described by Kwaan and Astrup. The inhibitory activity against fibrinolysis was graded according to the Lysis time of vascuLar tissues within the tumor. The results show chat all malignant solid tumors, with the exception of carcinoma of prostate demonstrate varying degrees of inhibition of fibrinolysis. Persistently high inhibitory activity was found in squamous cell carcinoma of esophagus, the respiratory tract (including squamous cell carcinoma of sinuses, larynx and lung), cervix uteri and skin; carcinoma of uterus, colo-rectal carcinoma; small cell anaplastic carcinoma of lung; neuroblastoma; carcinoma of bile duct; while malignant tumors of the kidney show a lesser degree of inhibition. In contrast, with the exception of hydatldiform mole, benign solid tumors show-little or no Inhibition. There is a difference in fibrinolytic activity between the peripheral and the central portions of a tumor with distinctly greater degree of activity in the former. The pathophysiologic implications of the presence of such a strong inhibition of fibrinolysis is apparent. Biochemical characterization of this inhibition is currently in progress.

scholarly journals THAP9-AS1/miR-133b/SOX4 positive feedback loop facilitates the progression of esophageal squamous cell carcinoma

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Jiwei Cheng ◽  
Haibo Ma ◽  
Ming Yan ◽  
Wenqun Xing
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Malignant Tumors ◽  
Migration And Invasion ◽  
Positive Feedback Loop

AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in the digestive system with a high incidence and poor prognosis. Long non-coding RNAs (LncRNA) have been reported to be closely associated with the occurrence and development of various human cancers. Data from GSE89102 shows an increase of THAP9-AS1 expression in ESCC. However, its functions and mechanisms underlying ESCC progression remain to be investigated. In this study, we found that THAP9-AS1 was overexpressed in ESCC tissues and cells. High THAP9-AS1 expression was positively correlated with tumor size, TNM stage, lymph node metastasis, and worse prognosis. Functionally, depletion of THAP9-AS1 suppressed cell proliferation, migration, and invasion, while enhanced apoptosis in vitro. Consistently, knockdown of THAP9-AS1 inhibited xenograft tumor growth in vivo. Mechanistically, THAP9-AS1 could serve as a competing endogenous RNA (ceRNA) for miR-133b, resulting in the upregulation of SOX4. Reciprocally, SOX4 bound to the promoter region of THAP9-AS1 to activate its transcription. Moreover, the anti-tumor property induced by THAP9-AS1 knockdown was significantly impaired due to miR-133b downregulation or SOX4 overexpression. Taken together, our study reveals a positive feedback loop of THAP9-AS1/miR-133b/SOX4 to facilitate ESCC progression, providing a potential molecular target to fight against ESCC.

Metastatic Anaplastic Carcinoma of the Thyroid Mimicking Squamous Cell Carcinoma

2006 ◽  
Vol 50 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Maja H. Oktay ◽  
Matthew B. Smolkin ◽  
Mark Williams ◽  
Antonio Cajigas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anaplastic Carcinoma

scholarly journals Storkhead box 2 and melanoma inhibitory activity promote oral squamous cell carcinoma progression

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26751-26764 ◽  
Author(s):  
Tomonori Sasahira ◽  
Yukiko Nishiguchi ◽  
Rina Fujiwara ◽  
Miyako Kurihara ◽  
Tadaaki Kirita ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

scholarly journals The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Chongwen Xu ◽  
Peng Han ◽  
Wanli Ren ◽  
Hao Dai ◽  
Yanxia Bai ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Protective Role ◽  
Neck Squamous Cell Carcinoma ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Purpose. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods. We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results. Our study revealed that rs7336610 (OR 1.77, 95 % CI = 1.09 ‐ 2.86 , and p = 0.021 ) and rs1428 (OR 1.73, 95 % CI = 1.07 ‐ 2.81 , and p = 0.025 ) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95 % CI = 0.12 ‐ 0.95 , and p = 0.040 ) compared with stage I/II. Conclusion. Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC.

Proposal for a New Histopathological Classification of the Carcinomas of the Nasopharynx

1978 ◽  
Vol 64 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Christian Micheau ◽  
Franco Rilke ◽  
Silvana Pilotti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Classification Scheme ◽  
Malignant Tumors ◽  
Undifferentiated Carcinoma ◽  
New Classification ◽  
Histopathological Classification ◽  
Potential Origin

A new classification scheme for malignant tumors of the nasopharynx is proposed in which the undifferentiated carcinoma of nasopharyngeal types as a prominent position. This term replaces the previous obsolete term lymphoepithelioma on the basis of its clinicopathologic identity, its separation from squamous cell carcinoma, and its potential origin from anatomical areas other than the nasopharynx.

Epidermoid Squamous Cell Carcinoma of the Cervix Uteri

1980 ◽  
pp. 285-286
Author(s):  
Mathilde E. Boon ◽  
Mette Lise Tabbers-Boumeester
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cervix Uteri

scholarly journals Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma

2013 ◽  
Vol 108 (7) ◽  
pp. 1460-1469 ◽  
Author(s):  
M Kurihara ◽  
T Kirita ◽  
T Sasahira ◽  
H Ohmori ◽  
S Matsushima ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Inhibitory Activity ◽  
Melanoma Inhibitory Activity

Progressive increasing in the risk of second and subsequent malignant tumors in patients with a head and neck cancer: A validation study with SEER data.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5595-5595
Author(s):  
Xavier Leon ◽  
Antonio Lopez-Pousa ◽  
J Carlos Villatoro ◽  
Miquel Quer ◽  
Ivana Sullivan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Progressive Increase ◽  
Aerodigestive Tract ◽  
Seer Program ◽  
Increased Risk

5595 Background: Patients with a head and neck squamous cell carcinoma (HNSCC) index tumor have a increased risk (2-4% per year) for appearance of a second malignant neoplasms (SMN) and higher risk for successive malignant tumors during the follow-up. The objective of our study was to validate this concept with data of patients included in the Surveillance Epidemiology and End Results (SEER) program (1973-2008). Methods: We performed a population-based cohort study of 149.328 patients with a primary oral cavity, oropharynx, hypopharynx and larynx squamous cell carcinoma index tumor, included in the SEER program, to analize the actuarial survival-free of second and successive tumors. A total of 11.948 (8%) patients had one or more malignant tumors before the diagnosis of HNSCC. Results: During the follow-up period, a total of 31.507 new SMN appeared. There was a progressive and significant increase in the risk of SMN. The annual hazard ratio for 2nd to 7th successive SMN was 2.3%, 2.7%, 3.9%, 5.4%, 8.9% and 19.1% annual risk respectively. Additionally 11 patients had 8th SMN. We observed a progressive increase in the risk of appearence of new malignant tumors located in and outside the aerodigestive tract. The increase in the risk of SMN was higher for tumors located in the aerodigestive tract than tumors located outside aerodigestive tract. It was a tendency towards the increase in the proportion of HNSCC with the appearance of new tumors, with a decrease in the proportion of the malignant tumors located in the lung and in locations outside the aerodigestive tract. There were significant differences inthe risk of SMN between second and third, third and fourth, fourth and fifth, and sist and seventh tumors (p<0.0001). Conclusions: In patients with HNSCC there is a progressive increase in the risk of appearance of successive tumors. Previous tobacco and alcohol consumption, persistence in the exposure to carcinogens and individual susceptibility (genetic) could play a role in the increased risk of SMN. We have validated this concept with data from the SEER program.

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