Thioredoxin-Interacting Protein: A Potential Therapeutic Target for Treatment of Progressive Fibrosis in Diabetic Nephropathy

Nephron ◽  
2015 ◽  
Vol 129 (2) ◽  
pp. 109-127 ◽  
Author(s):  
Christina Y.R. Tan ◽  
Qi Weier ◽  
Yuan Zhang ◽  
Alison J. Cox ◽  
Darren J. Kelly ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Therapeutic Target ◽  
Protein A ◽  
Potential Therapeutic Target ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein

scholarly journals Thioredoxin-Interacting Protein as a Novel Potential Therapeutic Target in Diabetes Mellitus and Its Underlying Complications

2020 ◽  
Vol Volume 13 ◽  
pp. 43-51 ◽  
Author(s):  
Dawit Zewdu Wondafrash ◽  
Asmelash Tesfay Nire'a ◽  
Gebrehiwot Gebremedihn Tafere ◽  
Desilu Mahari Desta ◽  
Demoze Asmerom Berhe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein

scholarly journals The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target

2021 ◽  
Vol 22 (4) ◽  
pp. 1693
Author(s):  
Alison Domingues ◽  
Julia Jolibois ◽  
Perrine Marquet de Rougé ◽  
Valérie Nivet-Antoine
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Therapeutic Target ◽  
Redox Status ◽  
Interacting Protein ◽  
Cellular Redox ◽  
Thioredoxin Interacting Protein ◽  
Potential Biomarker ◽  
Ischemic Diseases

Thioredoxin interacting protein (TXNIP) is a metabolism- oxidative- and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases.

scholarly journals Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

2015 ◽  
Vol 26 (12) ◽  
pp. 2963-2977 ◽  
Author(s):  
Anu Shah ◽  
Ling Xia ◽  
Elodie A.Y. Masson ◽  
Chloe Gui ◽  
Abdul Momen ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Protein Deficiency ◽  
Interacting Protein ◽  
Thioredoxin Interacting Protein
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