Serotonin and Microvascular Permeability

2015 ◽  
pp. 32-43 ◽  
Author(s):  
F. De Clerck ◽  
R. S. Reneman
Keyword(s):  
Microvascular Permeability

Increased cardiac microvascular permeability and activation of cardiac endothelial nitric oxide synthase in high tidal volume ventilation-induced lung injury

2010 ◽  
Vol 4 (1) ◽  
pp. 27-36
Author(s):  
Ming-Jui Hung ◽  
Ming-Yow Hung ◽  
Wen-Jin Cherng ◽  
Li-Fu Li
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lung Injury ◽  
Tidal Volume ◽  
Endothelial Nitric Oxide Synthase ◽  
Microvascular Permeability ◽  
Akt Phosphorylation ◽  
Enos Phosphorylation ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Abstract Background: Positive pressure ventilation with large tidal volumes has been shown to cause lung injury via the serine/threonine kinase-protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS)-pathways. However, the effects of high tidal volume (VT) ventilation on the heart are unclear. Objectives: Evaluate the effect of VT ventilation on the cardiac vascular permeability and intracellular Akt and eNOS signaling pathway. Methods: C57BL/6 and Akt knock-out (heterozygotes, +/−) mice were exposed to high VT (30 mL/kg) mechanical ventilation with room air for one and/or five hours. Results: High VT ventilation increased cardiac microvascular permeability and eNOS phosphorylation in a timedependent manner. Serum cardiac troponin I was increased after one hour of high VT ventilation. Cardiac Akt phosphorylation was accentuated after one hour and attenuated after five hours of high VT ventilation. Pharmacological inhibition of Akt with LY294002 and high VT ventilation of Akt+/− mice attenuated cardiac Akt phosphorylation, but not eNOS phosphorylation. Conclusion: High VT ventilation increased cardiac myocardial injury, microvascular permeability, and eNOS phosphorylation. Involvement of cardiac Akt in high VT ventilation was transient.

Endothelial nitric oxide synthase-derived NO signals regulate microvascular permeability

2007 ◽  
pp. 21-23
Author(s):  
Walter Durán ◽  
Takuya Hatakeyama ◽  
Fabiola Sánchez
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Microvascular Permeability ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat

2001 ◽  
Vol 90 (1) ◽  
pp. 261-268 ◽  
Author(s):  
Leonardo C. Clavijo ◽  
Mary B. Carter ◽  
Paul J. Matheson ◽  
Mark A. Wilson ◽  
William B. Wead ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Pulmonary Edema ◽  
Pulmonary Arterial Pressure ◽  
Ex Vivo ◽  
Platelet Activating Factor ◽  
Microvascular Permeability ◽  
Blue Dye ◽  
E Coli ◽  
Pulmonary Arterial

In vivo pulmonary arterial catheterization was used to determine the mechanism by which platelet-activating factor (PAF) produces pulmonary edema in rats. PAF induces pulmonary edema by increasing pulmonary microvascular permeability (PMP) without changing the pulmonary pressure gradient. Rats were cannulated for measurement of pulmonary arterial pressure (Ppa) and mean arterial pressure. PMP was determined by using either in vivo fluorescent videomicroscopy or the ex vivo Evans blue dye technique. WEB 2086 was administered intravenously (IV) to antagonize specific PAF effects. Three experiments were performed: 1) IV PAF, 2) topical PAF, and 3) Escherichia coli bacteremia. IV PAF induced systemic hypotension with a decrease in Ppa. PMP increased after IV PAF in a dose-related manner. Topical PAF increased PMP but decreased Ppa only at high doses. Both PMP (88 ± 5%) and Ppa (50 ± 3%) increased during E. coli bacteremia. PAF-receptor blockade prevents changes in Ppa and PMP after both topical PAF and E. coli bacteremia. PAF, which has been shown to mediate pulmonary edema in prior studies, appears to act in the lung by primarily increasing microvascular permeability. The presence of PAF might be prerequisite for pulmonary vascular constriction during gram-negative bacteremia.

scholarly journals Neurolysin substrates bradykinin, neurotensin and substance P enhance brain microvascular permeability in a human in vitro model

2021 ◽  
Vol 33 (2) ◽  
Author(s):  
Abraham J. Al‐Ahmad ◽  
Iqra Pervaiz ◽  
Vardan T. Karamyan
Keyword(s):  
Substance P ◽  
In Vitro Model ◽  
Microvascular Permeability ◽  
Vitro Model

Lung microvascular permeability and neutrophil recruitment are differently regulated by nitric oxide in a rat model of intestinal ischemia–reperfusion

2004 ◽  
Vol 494 (2-3) ◽  
pp. 241-249 ◽  
Author(s):  
Gabriela Cavriani ◽  
Ricardo Martins Oliveira-Filho ◽  
Aryene Góes Trezena ◽  
Zilma Lúcia da Silva ◽  
Helori Vanni Domingos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Model ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Microvascular Permeability ◽  
Neutrophil Recruitment ◽  
Intestinal Ischemia Reperfusion

Macromolecules reduce abnormal microvascular permeability in rat limb ischemia-reperfusion injury

1989 ◽  
Vol 17 (12) ◽  
pp. 1306-1309 ◽  
Author(s):  
BASHIR A. ZIKRIA ◽  
CHIVUKULA SUBBARAO ◽  
MEHMET C. OZ ◽  
SCOTT T. SHIH ◽  
PAUL F. MCLEOD ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Microvascular Permeability

Signal Transduction Pathways in Enhanced Microvascular Permeability

2000 ◽  
Vol 7 (6) ◽  
pp. 395-403 ◽  
Author(s):  
SARAH Y. YUAN
Keyword(s):  
Signal Transduction ◽  
Microvascular Permeability ◽  
Signal Transduction Pathways

Effect of Heparin on Increased Pulmonary Microvascular Permeability after Bone Marrow Embolism in Awake Sheep

1987 ◽  
Vol 136 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Kenneth E. Burhop ◽  
William M. Selig ◽  
Donald A. Beeler ◽  
Asrar B. Malik
Keyword(s):  
Bone Marrow ◽  
Microvascular Permeability ◽  
Bone Marrow Embolism ◽  
Marrow Embolism

The Effect of Tumor Necrosis Factor-?? on Microvascular Permeability in an Isolated, Perfused Lung

Shock ◽  
2002 ◽  
Vol 18 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Carl I. Schulman ◽  
Joseph K. Wright ◽  
Fiemu Nwariaku ◽  
George Sarosi ◽  
Richard H. Turnage
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Microvascular Permeability ◽  
Isolated Perfused Lung ◽  
Perfused Lung ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document