scholarly journals Hyperglycemia-Induced Modulation of the Physiognomy and Angiogenic Potential of Fibroblasts Mediated by Matrix Metalloproteinase-2: Implications for Venous Stenosis Formation Associated with Hemodialysis Vascular Access in Diabetic Milieu

2015 ◽  
Vol 52 (5) ◽  
pp. 334-346 ◽  
Author(s):  
Rajiv Janardhanan ◽  
Sreenivasulu Kilari ◽  
Edward B. Leof ◽  
Sanjay Misra
Keyword(s):  
Matrix Metalloproteinase ◽  
Vascular Access ◽  
Matrix Metalloproteinase 2 ◽  
Angiogenic Potential ◽  
Venous Stenosis ◽  
Hemodialysis Vascular Access

scholarly journals Advanced Stent Graft Treatment of Venous Stenosis Affecting Hemodialysis Vascular Access: Case Illustrations

2016 ◽  
Vol 33 (01) ◽  
pp. 039-045 ◽  
Author(s):  
Darshan Patel ◽  
R. Lokken ◽  
James Bui ◽  
Andrew Lipnik ◽  
Ron Gaba ◽  
...  
Keyword(s):  
Stent Graft ◽  
Vascular Access ◽  
Venous Stenosis ◽  
Hemodialysis Vascular Access

scholarly journals Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model

2013 ◽  
Vol 84 (2) ◽  
pp. 338-352 ◽  
Author(s):  
Rajiv Janardhanan ◽  
Binxia Yang ◽  
Pawan Vohra ◽  
Bhaskar Roy ◽  
Sarah Withers ◽  
...  
Keyword(s):  
Vascular Access ◽  
Venous Stenosis ◽  
Hemodialysis Vascular Access ◽  
Access Model

The Rat Femoral Arteriovenous Fistula Model: Increased Expression of Matrix Metalloproteinase–2 and −9 at the Venous Stenosis

2008 ◽  
Vol 19 (4) ◽  
pp. 587-594 ◽  
Author(s):  
Sanjay Misra ◽  
Alex A. Fu ◽  
Jill L. Anderson ◽  
Sanjeev Sethi ◽  
James F. Glockner ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Arteriovenous Fistula ◽  
Matrix Metalloproteinase 2 ◽  
Venous Stenosis

scholarly journals Rationale and Trial Design of MesEnchymal Stem Cell Trial in Preventing Venous Stenosis of Hemodialysis Vascular Access Arteriovenous Fistula (MEST AVF Trial)

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0005182021
Author(s):  
Ameet K. Piryani ◽  
Sreenivasulu Kilari ◽  
Edwin Takahashi ◽  
Randall R. DeMartino ◽  
Jay Mandrekar ◽  
...  
Keyword(s):  
Upper Extremity ◽  
Vascular Access ◽  
Trial Design ◽  
Phase 1 ◽  
Neointimal Hyperplasia ◽  
Ongoing Trial ◽  
Arteriovenous Fistulas ◽  
Venous Stenosis ◽  
Hemodialysis Vascular Access ◽  
Fistula Maturation

Background: Hemodialysis arteriovenous fistulas (AVFs) are the preferred vascular access for patients on hemodialysis. In the Hemodialysis Fistula Maturation Study, 43.7% of the patients achieved unassisted maturation of their fistula without needing an intervention. Venous neointimal hyperplasia (VNH) and subsequent venous stenosis (VS) is responsible for lack of maturation. There are no therapies that can prevent VNH/VS formation. The goal of this paper is to present the background, rationale, and trial design of an innovative phase 1 / 2 clinical study that is investigating the safety of autologous adipose derived mesenchymal stem cells (AMSCs) delivered locally to the adventitia of newly created upper extremity radiocephalic (RCF) or brachiocephalic fistula (BCF). Methods: The rationale and pre-clinical studies used to obtain a physician sponsored investigational new drug trial (IND) are discussed. The trial design and endpoints are discussed. Results: This is ongoing trial which will complete this year. Conclusion: This is a phase 1 / 2 single center, randomized trial which will investigate safety and efficacy of autologous AMSCs in promoting maturation in new upper extremity AVFs.

The upregulation of matrix metalloproteinase -2 and -9 genes caused by resistin in human chondrocytes

2014 ◽  
Vol 2 (1) ◽  
pp. 19 ◽  
Author(s):  
Kürşat Oğuz Yaykaşlı ◽  
Mustafa Doğan ◽  
Ertuğrul Kaya ◽  
Mustafa Özşahin ◽  
Emine Yaykaşlı ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Chondrocytes ◽  
Matrix Metalloproteinase 2
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