scholarly journals Concomitant B Hairy Cell Leukemia and Mycosis Fungoides in an Elderly Man

2017 ◽  
Vol 9 (1) ◽  
pp. 103-107
Author(s):  
Eric Wong ◽  
Muhammad N. Mahmood ◽  
Thomas G. Salopek
Keyword(s):  
Mycosis Fungoides ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Skin Lesions ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Acneiform Eruption ◽  
History Of ◽  
Low Prevalence ◽  
New Onset

The development of both a T- and B-cell lymphoproliferative disorder in one patient is an unlikely coincidence due to the low prevalence of each malignancy. We report a 65-year-old man with a previously documented history of B hairy cell leukemia, who presented with a new-onset acneiform eruption of his scalp, face, trunk, back, and extremities. Routine pathology of the skin lesions with immunohistochemical stains and molecular studies were consistent with a folliculotropic mycosis fungoides. B hairy cell leukemia and mycosis fungoides occurring in the same patient seems to be a rare phenomenon with only 5 cases reported in the literature.

Specific skin lesions in hairy cell leukemia at presentation: case report and review of literature

2009 ◽  
Vol 27 (2) ◽  
pp. 559-561 ◽  
Author(s):  
N. Čolović ◽  
M. Peruničić ◽  
V. Jurišić ◽  
M. Čolović
Keyword(s):  
Case Report ◽  
Hairy Cell Leukemia ◽  
Skin Lesions ◽  
Hairy Cell ◽  
Review Of Literature ◽  
Cell Leukemia

scholarly journals Leukopheresis therapy of leukemic reticuloendotheliosis (hairy cell leukemia)

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 747-749 ◽  
Author(s):  
JW Fay ◽  
JO Moore ◽  
GL Logue ◽  
AT Huang
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Hairy Cell Leukemia ◽  
Alternative Therapy ◽  
Leukemia Cell ◽  
Skin Lesions ◽  
Leukemia Cells ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Cell Counts

Abstract Intensive leukopheresis has been valuable in the short-term palliation of chronic lymphocytic and granulocytic leukemias. A 47-yr-old man with refractory leukemic reticuloendotheliosis (hairy cell leukemia) manifested by anemia, thrombocytopenia, elevated peripheral leukemia cell counts, generalized lymph node enlargement, and leukemic infiltrative skin disease was treated with serial leukopheresis. Removal of approximately 7 X 10(11) peripheral leukemia cells resulted in marked clinical and hematologic improvement with resolution of enlarged lymph nodes and clearing of skin infiltrates. At the time of this reporting, more than 400 wk since the last leukopheresis, the patient continues to do well. The improvement in all blood counts, reduction in lymph node size, and clearing of skin lesions paralleled the reduction of peripheral leukemia cell load by leukopheresis, suggesting mobilization of leukemia cells from marrow, lymph nodes, and skin. Removal of large numbers of leukemia cells in hairy cell leukemia has the potential of achieving sustained clinical improvement and may be a useful alternative therapy for these patients.

scholarly journals Diffuse osteosclerosis in hairy cell leukemia

Blood ◽  
1989 ◽  
Vol 74 (6) ◽  
pp. 2066-2069 ◽  
Author(s):  
LA VanderMolen ◽  
WJ Urba ◽  
DL Longo ◽  
J Lawrence ◽  
H Gralnick ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Interferon Alpha ◽  
Successful Treatment ◽  
Hairy Cell Leukemia ◽  
Malignant Disease ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Biopsies ◽  
Biopsy Needle ◽  
History Of

Abstract We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible etiologic mechanisms are discussed.

HSR19-086: Healthcare Costs and Resource Utilization Associated With Adverse Events Among Hairy Cell Leukemia Patients Treated With Purine Nucleoside Analogs

2019 ◽  
Vol 17 (3.5) ◽  
pp. HSR19-086
Author(s):  
Narendranath Epperla ◽  
Melissa Pavilack ◽  
Temitope Olufade ◽  
Richa Bashyal ◽  
Teng Huang ◽  
...  
Keyword(s):  
Adverse Events ◽  
Resource Utilization ◽  
Hairy Cell Leukemia ◽  
Opportunistic Infections ◽  
Nucleoside Analogs ◽  
Purine Nucleoside ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
History Of

Background: Purine nucleoside analogs (PNAs) are highly effective for first-line treatment of hairy cell leukemia (HCL). In clinical trials of single PNAs, several adverse events (AEs) were reported; however, little is known regarding the costs and healthcare resource utilization (HRU) resulting from AEs in HCL patients (pts) treated with PNAs in non-clinical trial settings. Objective: Determine the costs and HRU of high incident and clinically important AEs associated with PNA therapy in HCL pts in the Truven MarketScan database. Methods: Adults (aged ≥18 years) with ≥2 HCL diagnosis codes ≥30 days apart during January 1, 2006–December 31, 2015 were included. Pts had ≥1 prescription claim for a PNA (cladribine or pentostatin ± rituximab) after HCL diagnosis date. First PNA claim date was defined as the index date. Pts had continuous health plan enrollment for ≥6 months at baseline and ≥12-months follow-up with no PNA in the baseline period. Pts were placed into cohorts based on the occurrence of myelosuppression (MSPN) and opportunistic infections (OI) as these were highest incident and clinically important AEs observed. Generalized linear models were used to compare outcomes during the 12-month follow-up. Results: Of the 219 pts with no history of MSPN, 101 developed MSPN (incidence [I]: 461 per 1000 pt-years) and of 619 pts with no history of OI, 26 developed OI (I: 42 per 1000 pt-years). Demographics were similar between pts with and without MSPN and OI. Pts who developed OI or MSPN had significantly higher inpatient admissions and costs (Table 1). Conclusions: PNA-treated HCL pts who developed MSPN or OI incurred higher HRU than those who did not develop either condition. This indicates the need for new therapeutic strategies to reduce HCL-treatment-associated toxicities.

scholarly journals A unique malignant T-cell lymphoproliferative disorder with neutropenia simulating hairy cell leukemia

Cancer ◽  
1985 ◽  
Vol 56 (12) ◽  
pp. 2823-2830 ◽  
Author(s):  
Bernard R. Greenberg ◽  
Thomas M. Grogan ◽  
Bonnie J. Takasugi ◽  
Jeffrey M. Trent ◽  
Mary J. Hicks ◽  
...  
Keyword(s):  
T Cell ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Hairy Cell ◽  
Cell Leukemia

scholarly journals Two Cases of Q-Fever in Hairy Cell Leukemia

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Emanuele Ammatuna ◽  
Emilio Iannitto ◽  
Lidwine W. Tick ◽  
Nicolaas L. A. Arents ◽  
Philip H. Kuijper ◽  
...  
Keyword(s):  
Complete Remission ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Clinical Course ◽  
Q Fever ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Human Peripheral Blood Lymphocytes

Hairy cell leukemia (HCL) is a rare B-cell lymphoproliferative disorder accounting for about 2% of all leukemias. The clinical course is indolent, however HCL patients are particularly susceptible to infections. Here we report two cases of Q-fever as first manifestation of disease in two patients affected by HCL. Both patients described in this report showed an unusually sluggish clinical response to the antibiotic treatment with ciprofloxacin probably because of the marked immunodeficiency. However, treatment of HCL with cladribine administered soon after the resolution of QF pneumonitis was uneventful and led to a complete remission in both cases. Most probably the association of Coxiella burnetii (CB) infection and HCL that we observed in two patients is due to chance. However, a hairy cell resembling transformation of freshly isolated human peripheral blood lymphocytes upon CB has been showed. We think that the possibility of CB infection in febrile HCL patient should be always taken in mind, especially in endemic areas. In addition the potential for such infections to become chronic in HCL patients should not be overlooked and the reporting of further cases should be encouraged.

scholarly journals CD11c (LEU-M5) expression characterizes a B-cell chronic lymphoproliferative disorder with features of both chronic lymphocytic leukemia and hairy cell leukemia [see comments]

Blood ◽  
1990 ◽  
Vol 76 (11) ◽  
pp. 2360-2367
Author(s):  
CA Hanson ◽  
TE Gribbin ◽  
B Schnitzer ◽  
JA Schlegelmilch ◽  
BS Mitchell ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Cellular Adhesion ◽  
Lymphocytic Leukemia ◽  
Tartrate Resistant Acid Phosphatase ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Biopsies

Chronic lymphocytic leukemia (CLL) and hairy cell leukemia (HCL) are two common chronic lymphoproliferative disorders, each having characteristic clinical, morphologic, and immunologic features. Phenotypically, CD5 reactivity in CLL and CD11c (Leu-M5) reactivity in HCL have characterized these two leukemias among B-cell disorders. In this study, we report 14 cases of a novel chronic lymphoproliferative disorder characterized by lymphocytosis and CD11c expression, but morphologically similar to CLL. The patients' ages ranged from 46 to 81 years (median 62). Eleven had palpable splenomegaly, five with markedly enlarged spleens; only one patient had generalized lymphadenopathy. The white blood cell count ranged from 5.2 to 131.0 x 10(9)/L (median 20.8). The morphologic diagnosis in all cases was CLL, with the cells usually having abundant cytoplasm. No morphologic features, of hairy cells were evident; tartrate-resistant acid phosphatase cytochemistry was negative in all cases. Bone marrow biopsies were available in 8 of 14. Four showed focal nodular infiltrates and two had diffuse infiltrates similar to CLL; two showed only minimal interstitial involvement. All cases expressed multiple B-cell markers, and 12 of 14 had monoclonal surface immunoglobulin. The leukemic cells of all cases strongly expressed CD11c, while CD5 was expressed in 7 of 14; only 1 of the 14 cases expressed the lymph node homing receptor, Leu-8. This unique group of leukemias appears to represent the malignant transformation of lymphocytes arising from a stage of lymphocyte differentiation between that found in typical cases of CLL and that of HCL. CD11c is known to have an important function in cellular adhesion and may be important in determining the pattern of lymphocyte tissue distribution found in this group of patients.

scholarly journals CD11c (LEU-M5) expression characterizes a B-cell chronic lymphoproliferative disorder with features of both chronic lymphocytic leukemia and hairy cell leukemia [see comments]

Blood ◽  
1990 ◽  
Vol 76 (11) ◽  
pp. 2360-2367 ◽  
Author(s):  
CA Hanson ◽  
TE Gribbin ◽  
B Schnitzer ◽  
JA Schlegelmilch ◽  
BS Mitchell ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Hairy Cell Leukemia ◽  
Lymphoproliferative Disorder ◽  
Cellular Adhesion ◽  
Lymphocytic Leukemia ◽  
Tartrate Resistant Acid Phosphatase ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Bone Marrow Biopsies

Abstract Chronic lymphocytic leukemia (CLL) and hairy cell leukemia (HCL) are two common chronic lymphoproliferative disorders, each having characteristic clinical, morphologic, and immunologic features. Phenotypically, CD5 reactivity in CLL and CD11c (Leu-M5) reactivity in HCL have characterized these two leukemias among B-cell disorders. In this study, we report 14 cases of a novel chronic lymphoproliferative disorder characterized by lymphocytosis and CD11c expression, but morphologically similar to CLL. The patients' ages ranged from 46 to 81 years (median 62). Eleven had palpable splenomegaly, five with markedly enlarged spleens; only one patient had generalized lymphadenopathy. The white blood cell count ranged from 5.2 to 131.0 x 10(9)/L (median 20.8). The morphologic diagnosis in all cases was CLL, with the cells usually having abundant cytoplasm. No morphologic features, of hairy cells were evident; tartrate-resistant acid phosphatase cytochemistry was negative in all cases. Bone marrow biopsies were available in 8 of 14. Four showed focal nodular infiltrates and two had diffuse infiltrates similar to CLL; two showed only minimal interstitial involvement. All cases expressed multiple B-cell markers, and 12 of 14 had monoclonal surface immunoglobulin. The leukemic cells of all cases strongly expressed CD11c, while CD5 was expressed in 7 of 14; only 1 of the 14 cases expressed the lymph node homing receptor, Leu-8. This unique group of leukemias appears to represent the malignant transformation of lymphocytes arising from a stage of lymphocyte differentiation between that found in typical cases of CLL and that of HCL. CD11c is known to have an important function in cellular adhesion and may be important in determining the pattern of lymphocyte tissue distribution found in this group of patients.

Sign in / Sign up

Export Citation Format

Share Document