Neurohormonal Evaluation and Long-Term Treatment of Mild Congestive Heart Failure in Elderly Patients with Ihopamine: A Double-Blind, Placeho-Controlled Study

1991 ◽  
Vol 5 (S1) ◽  
pp. 23-31 ◽  
Author(s):  
A. Barabino ◽  
G. Di Benedetto ◽  
N. Musso ◽  
C. Vergassola ◽  
A. Azzolini ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Elderly Patients ◽  
Term Treatment ◽  
Controlled Study ◽  
Double Blind ◽  
Long Term Treatment

scholarly journals Long-term treatment of congestive heart failure with captopril.

1982 ◽  
Vol 14 (S2) ◽  
pp. 223S-229S
Author(s):  
M Komajda ◽  
M Eugene ◽  
J Evans ◽  
G Drobinski ◽  
JL Laurenceau ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Efficacy of Citalopram in the prevention of recurrent depression in elderly patients: Placebo-controlled study of maintenance therapy

2002 ◽  
Vol 181 (1) ◽  
pp. 29-35 ◽  
Author(s):  
René Klysner ◽  
Jesper Bent-Hansen ◽  
Hanne L. Hansen ◽  
Marianne Lunde ◽  
Elisabeth Pleidrup ◽  
...  
Keyword(s):  
Major Depression ◽  
Elderly Patients ◽  
Rating Scale ◽  
The Elderly ◽  
Term Treatment ◽  
Fixed Dose ◽  
Controlled Study ◽  
Recurrence Time ◽  
Long Term Treatment

BackgroundThe highly recurrent nature of major depression in the young and the elderly warrants long-term antidepressant treatment.AimsTo compare the prophylactic efficacy of citalopram and placebo in elderly patients; to evaluate long-term tolerability of citalopram.MethodOut-patients, ⩾65 years, with unipolar major depression (DSM – IV: 296.2 x or 296.3 x) and Montgomery – Åsberg Depression Rating Scale score ⩾22 were treated with citalopram 20–40 mg for 8 weeks. Responders continued on their final fixed dose of citalopram for 16 weeks before randomisation to double-blind treatment with citalopram or placebo for at least 48 weeks.ResultsNineteen of the 60 patients using citalopram v. 41 of the 61 patients using placebo had recurrence. Time to recurrence was significantly different between citalopram— and placebo-patients, in favour of citalopram (log-rank test, P < 0.0001). Long-term treatment was well tolerated.ConclusionsLong-term treatment with citalopram is effective in preventing recurrence of depression in the elderly and is well tolerated.

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