Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial

Neonatology ◽  
2017 ◽  
Vol 113 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Tobias Strunk ◽  
Sameer Pupala ◽  
Julie Hibbert ◽  
Dorota Doherty ◽  
Sanjay Patole
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Coconut Oil ◽  
Open Label ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

scholarly journals Enteral Lactoferrin Supplementation for Very Preterm Infants: A Randomised Controlled Trial

2018 ◽  
Author(s):  
James Griffiths ◽  
Paula Jenkins ◽  
Monika Vargova ◽  
Ursula Bowler ◽  
Edmund Juszczak ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

Direct swallowing training and oral sensorimotor stimulation in preterm infants: a randomised controlled trial

2021 ◽  
pp. fetalneonatal-2021-321945
Author(s):  
Ju Sun Heo ◽  
Ee-Kyung Kim ◽  
Sae Yun Kim ◽  
In Gyu Song ◽  
Young Mi Yoon ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Controlled Trial ◽  
Tube Feeding ◽  
Tertiary Hospital ◽  
Oral Feeding ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

ObjectiveTo evaluate the effects of direct swallowing training (DST) alone and combined with oral sensorimotor stimulation (OSMS) on oral feeding ability in very preterm infants.DesignBlinded, parallel group, randomised controlled trial (1:1:1).SettingNeonatal intensive care unit of a South Korean tertiary hospital.ParticipantsPreterm infants born at <32 weeks of gestation who achieved full tube feeding.InterventionsTwo sessions per day were provided according to the randomly assigned groups (control: two times per day sham intervention; DST: DST and sham interventions, each once a day; DST+OSMS: DST and OSMS interventions, each once a day).Primary outcomeTime from start to independent oral feeding (IOF).ResultsAnalyses were conducted in 186 participants based on modified intention-to-treat (63 control; 63 DST; 60 DST+OSMS). The mean time from start to IOF differed significantly between the control, DST and DST+OSMS groups (21.1, 17.2 and 14.8 days, respectively, p=0.02). Compared with non-intervention, DST+OSMS significantly shortened the time from start to IOF (effect size: −0.49; 95% CI: −0.86 to –0.14; p=0.02), whereas DST did not. The proportion of feeding volume taken during the initial 5 min, an index of infants’ actual feeding ability when fatigue is minimal, increased earlier in the DST+OSMS than in the DST.ConclusionsIn very preterm infants, DST+OSMS led to the accelerated attainment of IOF compared with non-intervention, whereas DST alone did not. The effect of DST+OSMS on oral feeding ability appeared earlier than that of DST alone.Trial registration numberClinicalTrials.gov Registry (NCT02508571).

scholarly journals A multi-centre randomised controlled trial of respiratory function monitoring during stabilisation of very preterm infants at birth

Resuscitation ◽  
2021 ◽  
Author(s):  
Henriëtte A. van Zanten ◽  
Kristel L.A.M. Kuypers ◽  
Erik W van Zwet ◽  
Jeroen J. van Vonderen ◽  
C. Omar F. Kamlin ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Respiratory Function ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomised Controlled

scholarly journals Immediate parent-infant skin-to-skin study (IPISTOSS): study protocol of a randomised controlled trial on very preterm infants cared for in skin-to-skin contact immediately after birth and potential physiological, epigenetic, psychological and neurodevelopmental consequences

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e038938 ◽  
Author(s):  
Agnes Linnér ◽  
Björn Westrup ◽  
Karoline Lode-Kolz ◽  
Stina Klemming ◽  
Siri Lillieskold ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Ethical Review ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Skin Contact ◽  
Vital Functions ◽  
Randomised Controlled ◽  
Skin To Skin

IntroductionIn Scandinavia, 6% of infants are born preterm, before 37 gestational weeks. Instead of continuing in the in-utero environment, maturation needs to occur in a neonatal unit with support of vital functions, separated from the mother’s warmth, nutrition and other benefits. Preterm infants face health and neurodevelopment challenges that may also affect the family and society at large. There is evidence of benefit from immediate and continued skin-to-skin contact (SSC) for term and moderately preterm infants and their parents but there is a knowledge gap on its effect on unstable very preterm infants when initiated immediately after birth.Methods and analysisIn this ongoing randomised controlled trial from Stavanger, Norway and Stockholm, Sweden, we are studying 150 infants born at 28+0 to 32+6 gestational weeks, randomised to receive care immediately after birth in SSC with a parent or conventionally in an incubator. The primary outcome is cardiorespiratory stability according to the stability of the cardiorespiratory system in the preterm score. Secondary outcomes are autonomic stability, thermal control, infection control, SSC time, breastfeeding and growth, epigenetic profile, microbiome profile, infant behaviour, stress resilience, sleep integrity, cortical maturation, neurodevelopment, mother-infant attachment and attunement, and parent experience and mental health.Ethics and disseminationThe study has ethical approval from the Swedish Ethical Review Authority (2017/1135-31/3, 2019–03361) and the Norwegian Regional Ethical Committee (2015/889). The study is conducted according to good clinical practice and the Helsinki declaration. The results of the study will increase the knowledge about the mechanisms behind the effects of SSC for very preterm infants by dissemination to the scientific community through articles and at conferences, and to the society through parenting classes and magazines.Study statusRecruiting since April 2018. Expected trial termination June 2021.Trial registration numberNCT03521310 (ClinicalTrials.gov).

scholarly journals Physiological-based cord clamping in very preterm infants — Randomised controlled trial on effectiveness of stabilisation

Resuscitation ◽  
2020 ◽  
Vol 147 ◽  
pp. 26-33 ◽  
Author(s):  
Ronny Knol ◽  
Emma Brouwer ◽  
Thomas van den Akker ◽  
Philip DeKoninck ◽  
Nan van Geloven ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Preterm Infants ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Cord Clamping ◽  
Randomised Controlled
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