Using the Capture-Recapture Method to Estimate the Incidence of Amyotrophic Lateral Sclerosis in Beijing, China

2018 ◽  
Vol 50 (1-2) ◽  
pp. 29-34 ◽  
Author(s):  
Shenghan Zhou ◽  
Silin Qian ◽  
Xiaohan Li ◽  
Liping Zheng ◽  
Wenbing Chang ◽  
...  

2018 ◽  
Vol 51 (3-4) ◽  
pp. 149-157 ◽  
Author(s):  
Lorene M. Nelson ◽  
Barbara Topol ◽  
Wendy Kaye ◽  
David Williamson ◽  
D. Kevin Horton ◽  
...  


2000 ◽  
Vol 53 (10) ◽  
pp. 1025-1029 ◽  
Author(s):  
Pierre-Marie Preux ◽  
Michel Druet-Cabanac ◽  
Philippe Couratier ◽  
Caroline Debrock ◽  
Tri Truong ◽  
...  


2005 ◽  
Vol 24 (3) ◽  
pp. 141-150 ◽  
Author(s):  
Cynthia J. Coffman ◽  
Ronnie D. Horner ◽  
Steven C. Grambow ◽  
Jennifer Lindquist


2013 ◽  
Vol 40 (2) ◽  
pp. 133-141 ◽  
Author(s):  
Michael Wittie ◽  
Lorene M. Nelson ◽  
Sharon Usher ◽  
Kevin Ward ◽  
Michael Benatar


2011 ◽  
Vol 82 (10) ◽  
pp. 1165-1170 ◽  
Author(s):  
M. H. B. Huisman ◽  
S. W. de Jong ◽  
P. T. C. van Doormaal ◽  
S. S. Weinreich ◽  
H. J. Schelhaas ◽  
...  


Author(s):  
Riley Golby ◽  
Brigitte Poirier ◽  
Marife Fabros ◽  
Jacquelyn J. Cragg ◽  
Masoud Yousefi ◽  
...  

AbstractBackground: Amyotrophic lateral sclerosis (ALS) is a fatal degenerative neurological disease with significant effects on quality of life. International studies continue to provide consistent incidence values, though complete case ascertainment remains a challenge. The Canadian population has been understudied, and there are currently no quantitative data on the incidence of ALS in British Columbia (BC). The objectives of this study were to determine the five-year incidence rates of ALS in BC and to characterize the demographic patterns of the disease. Methods: The capture–recapture method was employed to estimate ALS incidence over a five-year period (2010-2015). Two sources were used to identify ALS cases: one database from an ALS medical centre and another from a not-for-profit ALS organization. Results: During this time period, there were 690 incident cases within the two sources. The capture–recapture method estimated 57 unobserved cases, corresponding to a crude five-year incidence rate of 3.29 cases per 100,000 (CI95%=3.05-3.53). The mean age of diagnosis was 64.6 (CI95%=59.7-69.4), with 63.5 (CI95%=56.9-70.1) for men and 65.7 (CI95%=58.6-72.7) for women. There was a slight male preponderance in incidence, with a 1.05:1 ratio to females. Peak numbers in incidence occurred between the ages of 70 and 79. Conclusions: The incidence of ALS in BC was found to be consistent with international findings though nominally higher than that in other Canadian provinces to date.



2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.



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