scholarly journals Amnwiotic Membrane Transplantation as a Treatment for Sterile Infiltration and Corneal Melting after Corneal Crosslinking for Keratoconus

2018 ◽  
Vol 9 (1) ◽  
pp. 185-189 ◽  
Author(s):  
Takanori Sasaki ◽  
Takeshi Ide ◽  
Ikuko Toda ◽  
Naoko Kato
Keyword(s):  
Visual Acuity ◽  
Diclofenac Sodium ◽  
Corneal Stroma ◽  
Amniotic Membrane Transplantation ◽  
Eye Drops ◽  
Epithelial Defect ◽  
Persistent Epithelial Defect ◽  
Corneal Crosslinking ◽  
Corneal Epithelial Defect ◽  
Corneal Melting

We report a case of corneal melting through sterile infiltration presumably due to excessive use of nonsteroidal anti-inflammatory eye drops after corneal crosslinking (CXL). It was treated using steroids combined with amniotic membrane transplantation (AMT). A 33-year-old man with progressing keratoconus underwent left eye CXL. We prescribed betamethasone and levofloxacin eye drops 5 times daily and diclofenac sodium eye drops 3 times daily for 3 days. Three days after CXL, there was a persistent epithelial defect and the left corneal stroma was clouded. His visual acuity remained unchanged. We prescribed betamethasone hourly and 20 mg prednisolone daily. At 1 week after CXL, the corneal epithelial defect and infiltration were unchanged. He had not stopped using diclofenac at the prescribed time. On day 17, we performed AMT and his cornea and visual acuity improved. AMT may be effective against persistent epithelial defects and corneal melting after CXL.

scholarly journals A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma

2018 ◽  
Vol 9 (1) ◽  
pp. 114-118 ◽  
Author(s):  
Tomoko Sato ◽  
Koji Sugioka ◽  
Aya Kodama-Takahashi ◽  
Masahiko Fukuda ◽  
Hiroshi Mishima ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cavernous Sinus ◽  
Visual Disturbance ◽  
Amniotic Membrane Transplantation ◽  
Eye Drops ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Defect Area ◽  
Neurotrophic Keratopathy

Purpose: To report a case of neurotrophic keratopathy associated with nasopharyngeal carcinoma. Case Report: A 59-year-old man who had been diagnosed with a nasopharyngeal carcinoma was referred to the authors because of visual disturbance and pain in his right eye. Slit-lamp examination revealed a corneal epithelial defect and corneal stromal edema surrounding the epithelial defect area in his right eye. Magnetic resonance imaging showed a mass in his cavernous sinus, which was identified as nasopharyngeal carcinoma (NPC). We diagnosed neurotrophic keratopathy associated with NPC and initiated treatment with preservative-free artificial tears, antibiotic eye drops, fibronectin, a therapeutic contact lens, and amniotic membrane transplantation. However, the persistent corneal epithelial defect was unresponsive to these treatments. Conclusion: Neurotrophic keratopathy secondary to NPC is thought to be rare. We presented a case of neurotrophic keratopathy associated with cavernous sinus metastasis of an NPC. The development of new and more effective treatments for this refractory disease is anticipated.

scholarly journals A Case of Medication-Resistant Acanthamoeba Keratitis Treated by Corneal Crosslinking in Turkey

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Goktug Demirci ◽  
Akif Ozdamar
Keyword(s):  
Visual Acuity ◽  
Local Anesthesia ◽  
Symptomatic Relief ◽  
Acanthamoeba Keratitis ◽  
Symptomatic Improvement ◽  
Corneal Epithelial ◽  
Corneal Crosslinking ◽  
Corneal Melting

Purpose. To report a case of medication-resistant acanthamoeba keratitis (AK) treated successfully by corneal crosslinking (CXL).Methods. A 26-year-old male with medication-resistant AK underwent a standard CXL procedure with local anesthesia, followed by central corneal epithelial debridement, application of riboflavin 0.1%, and UV-A irradiation.Results. The patient experienced a dramatic symptomatic improvement within 24 hours. At two months, keratitis was healed with a semitransparent paracentral scar that did not affect visual acuity.Conclusions. Our experience, considered in the context of recent studies, suggests that CXL may be an option for selected patients with medication-resistant AK and corneal melting. CXL allows patients to avoid emergency keratoplasty and experience rapid symptomatic relief.

scholarly journals Erratum to “Topical 100% Serum Eye Drops for Treating Corneal Epithelial Defect after Ocular Surgery”

2014 ◽  
Vol 2014 ◽  
pp. 1-1
Author(s):  
Kaevalin Lekhanont ◽  
Passara Jongkhajornpong ◽  
Lulin Choubtum ◽  
Varintorn Chuckpaiwong
Keyword(s):  
Eye Drops ◽  
Epithelial Defect ◽  
Ocular Surgery ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Serum Eye Drops

Maternal finger-prick allogenic blood for persistent corneal epithelial defects

2021 ◽  
Vol 14 (4) ◽  
pp. e241138
Author(s):  
Rathin Pujari ◽  
Rashmi Deshmukh ◽  
Chirag Sheth ◽  
Madhavan S Rajan
Keyword(s):  
Symptomatic Improvement ◽  
Eye Drops ◽  
Age Group ◽  
Epithelial Defect ◽  
Persistent Epithelial Defect ◽  
Corneal Epithelial ◽  
Allogenic Blood ◽  
Finger Prick ◽  
Potential Alternative

This is a case of a 17-year-old patient with aniridia-related keratopathy and persistent epithelial defect (PED) treated successfully using maternal finger-prick blood (FPB). Maternal allogenic FPB treatment was initiated to the patient who was non-compliant with the use of autologous FPB. The PED was successfully managed with maternal FPB treatment with rapid and complete closure of the epithelial defect. Additionally, there was immediate and sustained symptomatic improvement to pain and recovery of vision in the only seeing eye. There was no immunological reaction to allogenic blood. Maternal finger-prick allogenic blood could serve as a potential alternative to serum eye drops or autologous FPB in the management of refractory PED, particularly in reference to the paediatric or the vulnerable age group. Further studies are required to confirm the role of allogenic blood in the treatment of PED.

scholarly journals Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy

2021 ◽  
Vol 10 (2) ◽  
pp. 43-49
Author(s):  
Nancy M. Lotfy ◽  
Tariq Alasbali ◽  
Abdulrahman M. Alsharif ◽  
Saeed M Al- Gehedan ◽  
Sabah Jastaneiah ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Pain Score ◽  
Contact Lens ◽  
Contact Lenses ◽  
Corneal Thickness ◽  
Photorefractive Keratectomy ◽  
Epithelial Defect ◽  
Silicone Hydrogel ◽  
Corneal Epithelial Defect ◽  
Significant Difference

Background: At completion of transepithelial photorefractive keratectomy (t-PRK) surgery, the eye is usually fitted with a bandage contact lens to reduce discomfort and promote epithelial healing. This study aimed to compare the outcomes of eyes fitted with lotrafilcon B versus comfilcon A, silicone hydrogel bandage contact lenses after t-PRK for the correction of low to moderate myopia, with or without astigmatism. Methods: In this comparative, prospective study, patients with myopia < -6 D with or without astigmatism (< 1.75 D), who underwent t-PRK between January and June 2018, were randomly allocated to the lotrafilcon B and comfilcon A groups. Preoperative characteristics, including age, sex, eye treated, uncorrected visual acuity (UCVA), best-corrected visual acuity, mesopic pupil size, central corneal thickness, and refractive error were recorded. Postoperatively, pain score, UCVA, and corneal epithelial defect size on days 1, 4, and 7 were compared between the two groups. Results: Twenty-nine eyes were included in each group. Demographic characteristics and preoperative measurements were similar between the two groups. UCVA was significantly improved on day 7 as compared to day 1 in the comfilcon A group (P = 0.03), but remained the same in the lotrafilcon B group (P = 0.70) as on day 1 postoperatively. There was no significant difference in UCVA between the two groups at any follow-up visits (all P > 0.05). The pain score on the first postoperative day was significantly higher in the lotrafilcon B-fitted eyes than in the comfilcon A group (P < 0.001), but was significantly reduced in both groups compared to day 1 (both P < 0.001). The epithelial defect in the comfilcon A group was significantly greater than in the lotrafilcon B group (P < 0.001) at day 1 postoperatively, with significant improvement in both groups (both P < 0.001). Conclusions: Healing responses were better with lotrafilcon B than with comfilcon A bandage contact lenses. The patients had a greater mean pain score with lotrafilcon B than with comfilcon A lenses on the first postoperative day, yet the final outcome was comparable between the two groups. We did not encounter any postoperative complications related to contact lens wear. How to cite this article: Lotfy NM, Alasbali T, Alsharif AM, Al-Gehedan SM, Jastaneiah S, Al-Hazaimeh A, Ali H, Khandekar R. Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer; 10(2): 1-7. https://doi.org/10.51329/mehdiophthal1420

scholarly journals Post-operative complications of penetrating corneal keratoplasty in patients with anterior segment toxic syndrome secondary to cataract surgery

2020 ◽  
Vol 45 (Suppl.3) ◽  
pp. e020105
Author(s):  
Elen Nishimoto Nishi ◽  
Vagner Loduca Lima ◽  
Glaucia Luciano da Veiga ◽  
Luiz Antonio de Brito Martins
Keyword(s):  
Visual Acuity ◽  
Postoperative Complications ◽  
Cataract Surgery ◽  
Survival Time ◽  
Graft Survival ◽  
Corneal Transplantation ◽  
Anterior Segment ◽  
Epithelial Defect ◽  
Persistent Epithelial Defect ◽  
Corneal Decompensation

Introduction: Toxic Anterior Segment Syndrome (TASS) after cataract surgery may cause severe corneal decompensation that compromises corneal transparency and may require penetrating corneal keratoplasty to improve visual acuity. Objective: We evaluated the postoperative complications of patients who underwent penetrating corneal transplantation for severe corneal decompensation secondary to TASS after cataract surgery, such as persistent epithelial defect, glaucoma, and primary and secondary transplant button failure. We will also evaluate pre- and postoperative visual acuity, graft survival time, and the presence of anterior chamber disorganization. Methods: Retrospective observational study in which a review of medical records of 9 patients diagnosed with TASS after cataract surgery who underwent penetrating corneal keratoplasty will occur. Results: In the present study all operated patients had glaucoma after penetrating corneal transplantation, and this presence of glaucoma was not correlated with graft survival time and with any other parameter evaluated. The presence of persistent epithelial defect correlated negatively with visual acuity. Conclusion: Postoperative complications of penetrating corneal transplantation in patients with TASS were frequent, such as glaucoma, primary and secondary button failure and persistent epithelial defect. The only complication that compromised visual acuity was the persistent epithelial defect. All patients evolved with glaucoma.

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