scholarly journals Massive Silicone-Induced Orbital Granuloma

2019 ◽  
Vol 6 (2) ◽  
pp. 145-150 ◽  
Author(s):  
Ann Shue ◽  
Jeffrey M. Joseph ◽  
Jeremiah P. Tao ◽  
Ann E. Barker-Griffith ◽  
Jerrold L. Abraham ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Foreign Body ◽  
Retinal Detachment ◽  
Silicone Oil ◽  
Intraoperative Complications ◽  
Giant Cells ◽  
Histopathologic Examination ◽  
Multinucleated Giant Cells ◽  
Retinal Surgery

We report a large subconjunctival-orbital granuloma in a 51-year-old male presenting with a blind painful right eye and marked chemosis 15 months after undergoing vitrectomy and silicone oil retinal tamponade for retinal detachment with no reported intraoperative complications. Gross and histopathologic examination of the enucleated eye and episcleral tumor revealed a bosselated mass measuring 17 × 10 × 5 mm containing prominent vacuoles with surrounding epithelioid histiocytes and foreign body multinucleated giant cells. Such a large silicone-induced orbital granuloma following uncomplicated retinal surgery in a grossly intact eye has not been previously reported to the authors’ knowledge. High intraocular pressure and emulsification of oil may facilitate silicone extravasation through scleral wounds after retinal surgery.

scholarly journals Pacing Lead-Induced Granuloma in the Atrium: A Foreign Body Reaction to Polyurethane

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Shinagawa Yoko ◽  
Yuka Kobayashi ◽  
Takao Iiri ◽  
Hitoshi Kitazawa ◽  
Masaaki Okabe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Foreign Body ◽  
Allergic Reaction ◽  
Superior Mesenteric Artery ◽  
Histological Examination ◽  
Mesenteric Artery ◽  
Foreign Body Reaction ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Pacing Lead

We described a case of an 82-year-old male who presented with a granuloma entrapping the polyurethane-coated pacing lead at the site of contact on the atrium. He had been paced for 8 years without symptoms or signs suggestive of an allergic reaction to the pacemaker system and died from thrombosis of the superior mesenteric artery and heart failure. A histological examination of the nodule showed an incidental granuloma with multinucleated giant cells. No granuloma was found in the heart or the lung.

scholarly journals Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Vision ◽  
2020 ◽  
Vol 4 (3) ◽  
pp. 36
Author(s):  
Michele Nicolai ◽  
Nicola Lassandro ◽  
Alessandro Franceschi ◽  
Alessandro Rosati ◽  
Serena De Turris ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Silicone Oil ◽  
Late Onset ◽  
Chemical Properties ◽  
Pressure Rise ◽  
Retinal Surgery ◽  
Physico Chemical ◽  
Postoperative Hypertension ◽  
Ocular Pressure ◽  
Closed Angle

Silicone oil represents the main choice for intraocular tamponade in cases of complicated retinal detachment surgery. The intraocular pressure of an eye filled with silicone oil could increase, driven by a variety of different forces, according to several mechanisms. Two main conditions have been highlighted, depending on the onset: early hypertension or late glaucoma. The different types of silicone oils and their physico-chemical properties are varied and may play a role in the determination of intraocular pressure rise. The current body of literature allows for the illustration and categorization of the incidence and risk factors, as well as the pathogenesis and the management of the early postoperative hypertension subtended by an open- and closed-angle, along with the late onset silicone oil-induced glaucoma. Understanding the leading actors on the stage of ocular pressure elevation concurrently with silicone oil application for retinal surgery could help in guiding the timely and appropriate course of treatment.

scholarly journals Pulse Granulomas of the Gastrointestinal Tract and Gallbladder: Report of Five Cases

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Tom C. DeRoche ◽  
Gregory A. Gates ◽  
Aaron R. Huber
Keyword(s):  
Gastrointestinal Tract ◽  
Foreign Body ◽  
Incidental Finding ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Ultrastructural Studies ◽  
Foreign Body Giant Cells ◽  
Edible Seeds ◽  
Mass Lesions ◽  
Vegetable Material

Hyaline rings with admixed multinucleated giant cells characterize pulse granulomas; the term pulse refers to edible seeds of legume vegetables. The etiology has been controversial, with theories including vascular degenerative changes or a reaction to vegetable material; ultrastructural studies and experimentally induced lesions in animals favor the latter. This lesion is typically seen in the oral cavity, with only rare reports in the gastrointestinal tract and gallbladder. We herein describe five cases of pulse granulomas identified in these sites. All cases contained foreign-body giant cells and vegetable debris within or near hyaline rings. Pulse granulomas may form mass lesions but are usually an incidental finding on microscopic examination. In incidentally detected cases, recognition of pulse granulomas can suggest a mural abscess, fistula, or perforation of the gut, findings which may not be grossly apparent. The presence of vegetable material in all five cases further supports an exogenous pathogenesis.

scholarly journals Outcome and Complications of Combined Phacoemulsification and 23-Gauge Pars Plana Vitrectomy

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Selcuk Sizmaz ◽  
Ebru Esen ◽  
Puren Isik ◽  
Burcu Cam ◽  
Nihal Demircan
Keyword(s):  
Intraocular Pressure ◽  
Retinal Detachment ◽  
Pars Plana Vitrectomy ◽  
Intraoperative Complications ◽  
Vitreous Hemorrhage ◽  
Patient Demographics ◽  
Posterior Synechia ◽  
Pars Plana ◽  
23 Gauge

Background. With the advances in surgical tools, simultaneous removal of cataract associated with vitreoretinal disorders is gaining popularity. This combined surgery offers several advantages besides limitations. The aim of this study is to assess the outcome and complications of phacoemulsification combined with pars plana vitrectomy (PPV). Patients and Methods. In this retrospective review, medical charts of patients undergoing phacovitrectomy for coexisting cataract and various vitreoretinal disorders were analyzed. Patient demographics, retinal diagnosis, visual acuities (VA) in logMAR, intraocular pressure (IOP), intraoperative and postoperative complications were assessed. Clear corneal phacoemulsification and 23-gauge transconjunctival PPV were administered in all cases. Results. Eighty-four eyes of 64 (76.2%) males and 20 (23.8%) females were enrolled. The average age of patients was 59.5 ± 13.8 (18–81). The average period of follow-up was 7.2 ± 7.5 months (1–36). The vitreoretinal diagnoses were as follows: 28 (33.3%) rhegmatogenous retinal detachment, 23 (27.4%) vitreous hemorrhage, 12 (14.3%) intraocular foreign body, 12 (14.3%) epiretinal membrane, 4 (4.8%) macular hole, 4 (4.8%) tractional retinal detachment, and 1 (1.2%) vitreomacular traction. The most common intraoperative complications were miosis and rupture of the posterior capsule (92.9% and 8.3%, respectively). In 8 (9.5%) cases, there was fibrin in the anterior chamber. Posterior synechia developed in 7 (8.3%) of cases. No severe increase in intraocular pressure was evident. Conclusion. Phacoemulsification combined with PPV is a safe and efficient way of management in cases where cataract coexists with vitreoretinal pathologies.

TRAP-Positive Multinucleated Giant Cells Are Foreign Body Giant Cells Rather Than Osteoclasts: Results From a Split-Mouth Study in Humans

2015 ◽  
Vol 41 (6) ◽  
pp. e257-e266 ◽  
Author(s):  
Jonas Lorenz ◽  
Alica Kubesch ◽  
Tadas Korzinskas ◽  
Mike Barbeck ◽  
Constantin Landes ◽  
...  
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Giant Cells ◽  
Tissue Response ◽  
Multinucleated Giant Cells ◽  
Bone Substitute Material ◽  
Foreign Body Giant Cells ◽  
Substitute Material

This study compared the material-specific tissue response to the synthetic, hydroxyapatite-based bone substitute material NanoBone (NB) with that of the xenogeneic, bovine-based bone substitute material Bio-Oss (BO). The sinus cavities of 14 human patients were augmented with NB and BO in a split-mouth design. Six months after augmentation, bone biopsies were extracted for histological and histomorphometric investigation prior to dental implant insertion. The following were evaluated: the cellular inflammatory pattern, the induction of multinucleated giant cells, vascularization, the relative amounts of newly formed bone, connective tissue, and the remaining bone substitute material. NB granules were well integrated in the peri-implant tissue and were surrounded by newly formed bone tissue. Multinucleated giant cells were visible on the surfaces of the remaining granules. BO granules were integrated into the newly formed bone tissue, which originated from active osteoblasts on their surface. Histomorphometric analysis showed a significantly higher number of multinucleated giant cells and blood vessels in the NB group compared to the BO group. No statistical differences were observed in regard to connective tissue, remaining bone substitute, and newly formed bone. The results of this study highlight the different cellular reactions to synthetic and xenogeneic bone substitute materials. The significantly higher number of multinucleated giant cells within the NB implantation bed seems to have no effect on its biodegradation. Accordingly, the multinucleated giant cells observed within the NB implantation bed have characteristics more similar to those of foreign body giant cells than to those of osteoclasts.

scholarly journals Outcome of scleral buckling with or without gas tamponade for recurrent retinal detachment in post-vitrectomy eyes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jun-Xing Bai ◽  
Xiao-Jian Zhang ◽  
An-Li Duan ◽  
Xiao-Yan Peng
Keyword(s):  
Retinal Detachment ◽  
Functional Outcomes ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Intraoperative Complications ◽  
Scleral Buckling ◽  
Gas Tamponade ◽  
Pars Plana ◽  
Air Tamponade

Abstract Background Treatment of recurrent retinal detachment (re-RD) following vitrectomy (post-gas/air tamponade and post-silicone oil removal) is challenging. Previously reported treatment is commonly revision pars plana vitrectomy (PPV) combined with tamponade, which is invasive and a burden both economically and emotionally when compared with scleral buckling (SB). The purpose of this study is to report anatomical and functional outcomes of SB with or without gas tamponade in eyes with recurrent retinal detachment (re-RD) that previously underwent PPV at least once. Methods We retrospectively reviewed the medical records of 14 patients (14 eyes) who underwent PPV at least once and were treated with SB after re-RD. Preoperative characteristics, intraoperative complications, and postoperative data were assessed. The final anatomical and functional outcomes were analyzed. Results The original PPV was performed for primary rhegmatogenous retinal detachment in 11 eyes, macular hole retinal detachment in 2 eyes, and myopic foveoschisis in 1 eye. Previously, 3 eyes underwent one PPV with gas tamponade, and the remaining 11 (79%) eyes underwent 2–5 operations. Seven eyes underwent the procedure with gas injection. At the last follow-up, 13 eyes achieved total retinal attachment and 1 eye had re-RD. The postoperative intraocular pressure was within the normal range, except in 1 eye (6 mmHg). The finest postoperative best-corrected visual acuity (BCVA) was 20/25. There was a significant improvement in BCVA from 20/160 ± 20/63 at baseline to 20/80 ± 20/50 at the last visit in the 13 successfully treated eyes (P = 0.025). Conclusions SB can be effective for re-RD after PPV in specific cases.

scholarly journals Intraocular Pressure Elevation within Six Days After Vitreoretinal Surgery with Silicone Oil Injection for Rhegmatogenous Retinal Detachment

2021 ◽  
Author(s):  
Xiaoyan Zhang ◽  
Xiaofeng Hao ◽  
Like Xie
Keyword(s):  
Intraocular Pressure ◽  
Retinal Detachment ◽  
Pars Plana Vitrectomy ◽  
Rhegmatogenous Retinal Detachment ◽  
Silicone Oil ◽  
Topical Steroid ◽  
Pressure Elevation ◽  
Intraocular Pressure Elevation ◽  
Pars Plana ◽  
Oil Injection

Abstract Background: We investigated the incidence of and risk factors for intraocular pressure elevation within 6 days following pars plana vitrectomy with silicone oil injection for rhegmatogenous retinal detachment. Methods: We reviewed the records of 55 patients in whom pars plana vitrectomy with silicone oil injection was performed. The intraocular pressure was evaluated before surgery and 1 day, 3 days, and 6 days post-operatively. Results: Intraocular pressure elevation was found in 49% of eyes within 6 days after surgery. A long duration of rhegmatogenous retinal detachment was significantly associated with intraocular pressure elevation on day 1 after surgery. Presence of diabetes was significantly associated with intraocular pressure elevation at 3 days post-operation. Intraocular pressure elevation may occur 6 days following topical steroid use. Conclusions: Intraocular pressure should be monitored regularly in the early post-operative period after pars plana vitrectomy with silicone oil injection for rhegmatogenous retinal detachment, especially in patients with prolonged detachment and diabetic history.

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