Meta-Analysis of the Diagnostic Accuracy of Primary Bone and Soft Tissue Sarcomas by <sup>18</sup>F-FDG-PET

The case material was collected from 3 Institutions with a total of 411 patients: 217 with primary bone tumor and 224 with soft tissue sarcomas. In the majority of patients lymphography was performed during the initial diagnostic workup. The lymphograms were interpreted as negative or positive for metastases. In bone tumors, the incidence of metastases was 21 %, ranging from 28 % for osteosarcoma to 18 % for Ewing's sarcoma and 13 % for chondrosarcoma. In tumors of the soft tissue, the frequency was somewhat higher (28%), with special regard to rhabdomyosarcoma (53%), anaplastic sarcoma (67 %), neurogenic sarcoma (42%) and synovial sarcoma (35%). In the group of bone sarcomas, primary hematogenous spread was 3 times more frequent than lymphogenous spread, while in soft tissue sarcomas, with a higher incidence of lymphatic spread, this finding was inverted. In the more consistent tumor groups, the occurrence of lymphatic metastases indicated a significant worsening of the prognosis. In 96 patients, lymph node biopsies were performed and the radiologic histologic correlation gave evidence of a 91.7 % overall diagnostic accuracy.

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Diagnostic Accuracy of Follow-Up FDG PET or PET/CT in Patients With Head and Neck Cancer After Definitive Treatment: A Systematic Review and Meta-Analysis

American Journal of Roentgenology ◽

10.2214/ajr.14.14166 ◽

2015 ◽

Vol 205 (3) ◽

pp. 629-639 ◽

Cited By ~ 43

Author(s):

Sara Sheikhbahaei ◽

Mehdi Taghipour ◽

Rubina Ahmad ◽

Carole Fakhry ◽

Ana P. Kiess ◽

...

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Diagnostic Accuracy ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Meta Analysis ◽

Definitive Treatment ◽

Pet Ct

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Integrated 18F–FDG PET/MRI compared to MRI alone for identification of local recurrences of soft tissue sarcomas: a comparison trial

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-017-3736-y ◽

2017 ◽

Vol 44 (11) ◽

pp. 1823-1831 ◽

Cited By ~ 15

Author(s):

Youssef Erfanian ◽

Johannes Grueneisen ◽

Julian Kirchner ◽

Axel Wetter ◽

Lars Erik Podleska ◽

...

Keyword(s):

Soft Tissue ◽

Fdg Pet ◽

Soft Tissue Sarcomas ◽

Local Recurrences ◽

Comparison Trial ◽

18F Fdg

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Sarcomas of Soft Tissue and Bone

10.2310/im.1187 ◽

2011 ◽

Author(s):

Adam Lerner ◽

Huihong Xu ◽

Karen H Antman

Keyword(s):

Soft Tissue ◽

Meta Analysis ◽

Survival Rates ◽

Fibrous Tissue ◽

Soft Tissue Sarcomas ◽

Kaposi Sarcoma ◽

Uterine Leiomyosarcoma ◽

Increased Risk ◽

Bone Sarcomas ◽

Epidemiologic Features

Sarcomas originate from bone or soft tissue. The most common bone sarcomas are osteosarcomas, Ewing sarcomas, and chondrosarcomas. Soft tissue sarcomas develop in fibrous tissue, fat, muscle, blood vessels, and nerves. Historically, soft tissue sarcomas of the trunk and extremities were reported separately from those of visceral organs (e.g., gastrointestinal and gynecologic sarcomas). This chapter discusses the classification, epidemiology, diagnosis, staging, and treatment of sarcomas of bone and cartilage, and classic soft tissue sarcomas. Management of Kaposi sarcoma, gastrointestinal stromal tumors (GISTs), mesothelioma, and rhabdomyosarcoma is also described. Figures include images of patients with osteosarcoma, liposarcoma, uterine leiomyosarcoma, GIST, and osteosarcoma in a patient with Paget disease of bone. Tables list epidemiologic features of sarcomas, a summary of sarcomas by histology, familial syndromes associated with increased risk of sarcoma, survival rates in sarcoma patients, staging of soft tissue sarcomas, and results of a meta-analysis of doxorubicin-based adjuvant chemotherapy for localized resectable soft tissue sarcoma. This chapter contains 126 references.

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