Comparison of Prodromal Symptoms of Patients with Behavioral Variant Frontotemporal Dementia and Alzheimer Disease

2020 ◽  
Vol 49 (1) ◽  
pp. 98-106
Author(s):  
Titta Korhonen ◽  
Kasper Katisko ◽  
Antti Cajanus ◽  
Päivi Hartikainen ◽  
Anne M. Koivisto ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Prodromal Symptoms ◽  
Behavioral Variant Frontotemporal Dementia

scholarly journals Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease

2020 ◽  
Vol 33 (2) ◽  
pp. 68-72
Author(s):  
Oleg Yerstein ◽  
Andrew R. Carr ◽  
Elvira Jimenez ◽  
Mario F. Mendez
Keyword(s):  
Decision Making ◽  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Ultimatum Game ◽  
Neuropsychiatric Symptoms ◽  
The Other ◽  
Healthy Controls ◽  
Neuropsychiatric Inventory ◽  
Behavioral Variant Frontotemporal Dementia

Background: Neuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD). Methods: Using a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI). Results: Overall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC ( P < .01). On the NPI, the only domain that was significantly worse among the patients with AD compared to the other groups was dysphoria/depression. Conclusions: These results suggest that early AD can be distinguished based on increased rejections of offers in decision-making, possibly consequent to a heightened sense of unfairness from dysphoria/depression.

Direct and Indirect Assessments of Activities of Daily Living in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease

2014 ◽  
Vol 28 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Thais Bento Lima-Silva ◽  
Valéria Santoro Bahia ◽  
Viviane Amaral Carvalho ◽  
Henrique Cerqueira Guimarães ◽  
Paulo Caramelli ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Activities Of Daily Living ◽  
Frontotemporal Dementia ◽  
Daily Living ◽  
Behavioral Variant Frontotemporal Dementia

Divergent Social Functioning in Behavioral Variant Frontotemporal Dementia and Alzheimer Disease: Reciprocal Networks and Neuronal Evolution

2007 ◽  
Vol 21 (4) ◽  
pp. S50-S57 ◽  
Author(s):  
William W. Seeley ◽  
John M. Allman ◽  
Danielle A. Carlin ◽  
Richard K. Crawford ◽  
Marcelo N. Macedo ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Social Functioning ◽  
Frontotemporal Dementia ◽  
Behavioral Variant Frontotemporal Dementia

scholarly journals Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias

2019 ◽  
Vol 34 (5) ◽  
pp. 337-343 ◽  
Author(s):  
Letizia G. Borges ◽  
Alfred W. Rademaker ◽  
Eileen H. Bigio ◽  
M-Marsel Mesulam ◽  
Sandra Weintraub
Keyword(s):  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Frontotemporal Lobar Degeneration ◽  
Neuropsychiatric Symptom ◽  
Retrospective Data ◽  
Alzheimer Type ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Dementia Severity ◽  
Over Time

Objectives: Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD). Methods: Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD. Results: Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; P < .0001). Over time, apathy became more frequent in AD with increasing dementia severity (33%-41%; P < .006). Conclusions: Alzheimer disease neuropathology had the closest association with the neuropsychiatric symptom of apathy, while FTLD was most associated with the combination of apathy and disinhibition. Over time, the frequency of those with apathy increased in both AD and FTLD neuropathology.

scholarly journals Multidimensional Apathy in Behavioral Variant Frontotemporal Dementia, Primary Progressive Aphasia, and Alzheimer Disease

2020 ◽  
pp. 089198872092471
Author(s):  
Ratko Radakovic ◽  
Shuna Colville ◽  
Denise Cranley ◽  
John M. Starr ◽  
Suvankar Pal ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Primary Progressive Aphasia ◽  
Future Research ◽  
Self Awareness ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Patient Groups ◽  
Rating Discrepancy

Apathy is prevalent in dementia, such as behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), and Alzheimer disease (AD). As a multidimensional construct, it can be assessed and subsumed under a Dimensional Apathy Framework. A consistent apathy profile in bvFTD and PPA has yet to be established. The aim was to explore apathy profiles and awareness in bvFTD, PPA, and AD. A total of 12 patients with bvFTD, 12 patients with PPA, 28 patients with AD, and 20 matched controls, as well as their informants/carers, were recruited. All participants completed the Dimensional Apathy Scale (DAS), assessing executive, emotional, and initiation apathy subtypes, a 1-dimensional apathy measure, depression measure, and functional and cognitive screens. Apathy subtype awareness was determined through DAS informant/carer and self-rating discrepancy. Apathy profile comparison showed patients with bvFTD had significantly higher emotional apathy than patients with AD ( P < .01) and significantly higher apathy over all subtypes than patients with PPA ( Ps < .05). Additionally, patients with bvFTD had significantly lower awareness for emotional apathy ( P < .01) when compared to patients with AD and PPA. All patient groups had significant global apathy over all subtypes compared to controls. The emergent apathy profile for bvFTD seems to be emotional apathy (indifference or emotional/affective neutrality), with lower self-awareness in this subtype. Further, lower self-awareness for executive apathy (lack of motivation for planning, organization, or attention) differentiates bvFTD from PPA. Future research should investigate the cognitive and neural correlates as well as the practical impact of apathy subtypes.

[P2-269]: THE SHORT-TERM MEMORY BINDING TEST DIFFERENTIATES ALZHEIMER DISEASE FROM BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA PATIENTS WITH AMNESTIC DEFICITS

2017 ◽  
Vol 13 (7S_Part_14) ◽  
pp. P716-P717
Author(s):  
Mario Amore Cecchini ◽  
Monica Sanches Yassuda ◽  
Valeria S. Bahia ◽  
Thais Bento Lima-Silva ◽  
Luciana Cassimiro ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Short Term Memory ◽  
Short Term ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Term Memory ◽  
Memory Binding ◽  
Dementia Patients

Clinical and Biological Correlates of White Matter Hyperintensities in Patients With Behavioral-Variant Frontotemporal Dementia and Alzheimer Disease

Neurology ◽  
2021 ◽  
Vol 96 (13) ◽  
pp. e1743-e1754
Author(s):  
Katharine Huynh ◽  
Olivier Piguet ◽  
John Kwok ◽  
Carol Dobson-Stone ◽  
Glenda M. Halliday ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer Disease ◽  
Frontotemporal Dementia ◽  
Disease Severity ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Cortical Atrophy ◽  
Vascular Risk ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Cognitive Domains

ObjectiveTo test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy, and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses.MethodsA total of 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI and clinical and neuropsychological examination. Genetic screening was conducted in 124 cases (54 bvFTD, 44 AD, 26 controls) and postmortem pathology was available in 18 cases (13 bvFTD, 5 AD). WMH were extracted using an automated segmentation algorithm and analyses of total volumes and spatial distribution were conducted. Group differences in total WMH volume and associations with vascular risk and disease severity were examined. Syndrome-specific voxel-wise associations between WMH, cortical atrophy, and performance across different cognitive domains were assessed.ResultsTotal WMH volumes were larger in patients with bvFTD than patients with AD and controls. In bvFTD, WMH volumes were associated with disease severity but not vascular risk. Patients with bvFTD and patients with AD showed distinct spatial patterns of WMH that mirrored characteristic patterns of cortical atrophy. Regional WMH load correlated with worse cognitive performance in discrete cognitive domains. WMH-related cognitive impairments were shared between syndromes, with additional associations found in bvFTD.ConclusionIncreased WMH are common in patients with bvFTD and patients with AD. Our findings suggest that WMH are partly independent of vascular pathology and associated with the neurodegenerative process. WMH occur in processes independent of and related to cortical atrophy. Furthermore, increased WMH in different regions contributes to cognitive deficits.

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