IgG4 Expression in Patients with Eosinophilic Otitis Media

ORL ◽  
2021 ◽  
pp. 1-5
Author(s):  
Masahiro Takahashi ◽  
Aiko Oka ◽  
Shin Kariya ◽  
Yuka Gion ◽  
Yasuharu Sato ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Profound Hearing Loss ◽  
Middle Ear Mucosa ◽  
Type 2 Cytokines ◽  
Cochlear Implant Surgery ◽  
Middle Ear Disease ◽  
Type 2 Inflammation ◽  
Ear Effusion

Objective: Eosinophilic otitis media (EOM) is an intractable middle ear disease recognized by an eosinophil enriched middle ear effusion and mucosa. Although precise pathogenesis of EOM remains unclear, it is characterized by type 2 inflammation. Since IgG4 is an IgG subclass induced by type 2 cytokines such as IL-4 and IL-13, we sought to characterize and compare local IgG4 expression in patients with and without EOM. Methods: Twelve patients with bilateral profound hearing loss, 9 of which underwent a cochlear implant surgery, were enrolled in this study (6 with EOM and 6 without EOM). The surgical specimens were harvested during surgery and were subjected to IgG4 immunostaining. Result: The middle ear mucosa showed the presence of a large number of IgG4-positive cells in patients with EOM, which was significantly higher than that in patients without EOM. Conclusion: Local IgG4 expression was observed in patients with EOM in comparison to those without EOM, suggesting that IgG4 contributes to EOM pathogenesis.

Otitis Media with Effusion During the First Three Years of Life and Development of Speech and Language

PEDIATRICS ◽  
1984 ◽  
Vol 74 (2) ◽  
pp. 282-287 ◽  
Author(s):  
David W. Teele ◽  
Jerome O. Klein ◽  
Bernard A. Rosner ◽  
Keyword(s):  
Standardized Tests ◽  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Middle Ear Effusion ◽  
Speech And Language ◽  
Middle Ear Disease ◽  
Ear Effusion

To determine the association between time spent with middle ear effusion and development of speech and language, 205 three-year-old children were studied. Each child had been followed prospectively from birth to record the number of episodes of middle ear disease and to document time spent with middle ear effusion. Standardized tests of speech and language were administered at age 3 years to children who had spent much time with middle ear effusion and to children who had spent little or no time with middle ear effusion. Children who had spent prolonged periods of time with middle ear effusion had significantly lower scores when compared with those who had spent little time with middle ear disease. The correlation was strongest in children from higher socio-economic strata. Time spent with middle ear effusion in the first 6 to 12 months of life was most strongly associated with poor scores.

Epidemiology of Secretory Otitis Media a Descriptive Cohort Study

1983 ◽  
Vol 92 (2) ◽  
pp. 172-177 ◽  
Author(s):  
M. Fiellau-Nikolajsen
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Spontaneous Recovery ◽  
Average Duration ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Group Population ◽  
Fluctuating Course ◽  
Middle Ear Disease ◽  
Ear Effusion

To determine the prevalence, incidence, and course of secretory otitis media in an age-group population, 404 3-year-old children in a town in Denmark were examined at 6-, 8-, and 12-week intervals over a 6-month period. At each of the four examinations approximately 20% of the children had middle ear effusion (MEE); it was found at least once in 42% of the children, and 6% had persistent effusion at all four examinations. Average duration of MEE was 3 months. Since spontaneous recovery rarely occurred when MEE had been present for more than 3 months, active intervention is recommended after the condition has been followed for this length of time. The highly fluctuating course of MEE demonstrated in early childhood has important implications for concepts in pediatric middle ear disease and treatment.

Arachidonic Acid Metabolites in Experimental Otitis Media and Effects of Anti-Inflammatory Drugs

1993 ◽  
Vol 102 (12) ◽  
pp. 954-960 ◽  
Author(s):  
Pamela Goldie ◽  
Timothy T. K. Jung ◽  
Sten Hellström
Keyword(s):  
Arachidonic Acid ◽  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Middle Ear Effusion ◽  
Middle Ear Mucosa ◽  
Cold Air ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ear Effusion

Previous studies have shown that arachidonic acid (AA) metabolites are important in the pathogenesis of otitis media with effusion. The AA metabolites in 4 different experimental models for otitis media were analyzed, and the effect of anti-inflammatory drugs was studied. Purulent otitis media was induced in rats by inoculation of Streptococcus pneumoniae in the tympanic bulla, serous otitis media by blocking the tympanal orifice of the eustachian tube, and mucoid otitis media by combining the two procedures. Middle ear effusion was also induced by stimulating the external auditory canal with cold air. Indomethacin and hydrocortisone were used to inhibit AA metabolism in the latter model. Lipoxygenase products dominated in the purulent and cold air otitis media models. Cyclooxygenase products dominated in the mucoid and serous models. Indomethacin inhibited accumulation of middle ear effusion in the cold air otitis media model, whereas hydrocortisone did not Apart from AA metabolites, other mechanisms and mediators appear to be responsible for the increased vessel permeability observed in the cold air otitis media model, such as interactions between mast cells and nerves in the middle ear mucosa.

Effect of S-Carboxymethylcysteine on the Clearance of Middle Ear Effusion

1994 ◽  
Vol 103 (7) ◽  
pp. 567-575 ◽  
Author(s):  
Fumihiko Hori ◽  
Hideyuki Kawauchi ◽  
Goro Mogi
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Autoradiographic Study ◽  
Secretory Cells ◽  
Middle Ear Mucosa ◽  
Immune Mediated ◽  
Prophylactic Use ◽  
Different Doses ◽  
Ear Effusion

The therapeutic effect of S-carboxymethylcysteine (S-CMC) on otitis media with effusion was investigated by use of immune-mediated otitis media with effusion (OME) induced in chinchillas. The S-CMC was administered daily to individuals in two different doses (100 mg/kg and 200 mg/kg) for 2 weeks after the induction of immune-mediated otitis media. The severity of OME was evaluated by observation of the tympanic membrane under a surgical microscope, by tympanogram, and by histologic findings of the middle ear mucosa. Results of the study showed that the oral administration of S-CMC at a dose of 200 mg/kg of body weight is more effective than at a dose of 100 mg/kg in the clearance of middle ear effusions in experimental OME. An autoradiographic study using 14C-S-CMC revealed that orally administered S-CMC is rapidly absorbed by the digestive tract and transported to the tubotympanum via the circulation. The uptake and excretion by secretory cells were apparently greater in activated secretory cells. However, S-CMC does not act on the infiltrating cells to prevent the release of chemical mediators such as histamine and prostaglandin E2. This finding suggests that prophylactic use of S-CMC may not be anticipated.

Sinonasal symptoms in adults with ear disease

2014 ◽  
Vol 128 (5) ◽  
pp. 438-441 ◽  
Author(s):  
B-S Yin ◽  
M S Miah ◽  
S S M Hussain
Keyword(s):  
Middle Ear ◽  
Disease Treatment ◽  
Middle Ear Mucosa ◽  
Ear Diseases ◽  
Mucosal Disease ◽  
Tube Dysfunction ◽  
Middle Ear Disease ◽  
The Mean ◽  
Ear Effusion ◽  
Sinonasal Symptoms

AbstractBackground:The association between eustachian tube dysfunction and middle-ear effusion is well established. Studies have also demonstrated pathological changes affecting the middle-ear mucosa associated with chronic sinonasal inflammation. No previous studies have evaluated symptoms related to sinonasal inflammatory disease in different ear diseases.Objective:To assess the presence of sinonasal symptoms in ear diseases using the Dundee Rhinogram.Methods:Data were collected prospectively in the period February–October 2011. Sinonasal symptoms were graded using the Dundee Rhinogram. Student'st-test analyses were performed to identify any statistically significant associations.Results:In total, 164 patients were assessed. There was a statistically significant association between sinonasal symptoms and mucosal middle-ear diseases (p < 0.005). The mean sinonasal symptoms score for mucosal middle-ear disease patients was 5.94 (range, 0–32).Conclusion:Assessment of sinonasal symptoms is paramount in patients presenting with an ear symptom; inflammatory sinonasal disease treatment may become necessary in the management of middle-ear mucosal disease for better patient outcome.

New Sign of Middle Ear Disease?

PEDIATRICS ◽  
1984 ◽  
Vol 73 (6) ◽  
pp. 883-883
Author(s):  
JOHN M. PASCOE
Keyword(s):  
Antibiotic Therapy ◽  
Medical School ◽  
Otitis Media ◽  
Residency Training ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Middle Ear Disease ◽  
Ear Effusion

To the Editor.— For years I have observed children pulling on their ears "in sickness and in health." Now, my 11-month-old daughter has introduced me to a new symptom of middle ear disease that was not described during my medical school or residency training. In addition, I have never observed it in my patients. She developed a right purulent otitis media and was treated with antibiotics. Following ten days of antibiotic therapy, she developed a persistent middle ear effusion for about 2 months.

scholarly journals Adenoidectomy for middle ear disease in cleft palate children: a systematic review

2021 ◽  
Author(s):  
Cecilia Rosso ◽  
Antonio Mario Bulfamante ◽  
Carlotta Pipolo ◽  
Emanuela Fuccillo ◽  
Alberto Maccari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cleft Palate ◽  
Otitis Media ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Case Series ◽  
Velopharyngeal Insufficiency ◽  
Middle Ear Disease ◽  
Conductive Hearing

Abstract Purpose Cleft palate children have a higher incidence of otitis media with effusion, more frequent recurrent acute otitis media episodes, and worse conductive hearing losses than non-cleft children. Nevertheless, data on adenoidectomy for middle ear disease in this patient group are scarce, since many feared worsening of velopharyngeal insufficiency after the procedure. This review aims at collecting the available evidence on this subject, to frame possible further areas of research and interventions. Methods A PRISMA-compliant systematic review was performed. Multiple databases were searched with criteria designed to include all studies focusing on the role of adenoidectomy in treating middle ear disease in cleft palate children. After duplicate removal, abstract and full-text selection, and quality assessment, we reviewed eligible articles for clinical indications and outcomes. Results Among 321 unique citations, 3 studies published between 1964 and 1972 (2 case series and a retrospective cohort study) were deemed eligible, with 136 treated patients. The outcomes were positive in all three articles in terms of conductive hearing loss improvement, recurrent otitis media episodes reduction, and effusive otitis media resolution. Conclusion Despite promising results, research on adenoidectomy in treating middle ear disease in the cleft population has stopped in the mid-Seventies. No data are, therefore, available on the role of modern conservative adenoidectomy techniques (endoscopic and/or partial) in this context. Prospective studies are required to define the role of adenoidectomy in cleft children, most interestingly in specific subgroups such as patients requiring re-tympanostomy, given their known risk of otologic sequelae.

Antibacterial Therapy and Middle Ear Effusions

1976 ◽  
Vol 85 (2_suppl) ◽  
pp. 250-253 ◽  
Author(s):  
Paul A. Shurin
Keyword(s):  
Drug Therapy ◽  
Effective Treatment ◽  
Otitis Media ◽  
Middle Ear ◽  
Middle Ear Effusion ◽  
Prolonged Administration ◽  
Antimicrobial Drugs ◽  
Acute Attacks ◽  
Ear Effusion

Antimicrobial drugs chosen for their activity against the causative pathogens of otitis media provide effective treatment for acute attacks. Prolonged administration of some of these agents has recently been shown to be of value in the prevention of symptomatic otitis. The role of drug therapy in the management of chronic or recurrent middle ear effusion is unknown at present.

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