Studies on Fletcher trait and Fitzgerald trait
2010 ◽
Vol 104
(11)
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pp. 867-874
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Keyword(s):
SummaryThe way by which contact of blood with foreign surface accelerates clotting has been elucidated from the discovery of four rare disorders of blood coagulation; Hageman trait, plasma thromboplastin antecedent (PTA) deficiency, Fletcher trait, and Fitzgerald trait. Interestingly, it was unexpectedly found that Fletcher factor is plasma prekallikrein and Fitzgerald factor is high-molecular-weight kininogen; components of the kinin-generating system, thus disclosing intimate relationships among clotting, fibrinolysis and kinin generation which may be viewed as body’s defense reactions against injury. This review mainly reflects our research on Fletcher trait and Fitzgerald trait during the 1970s in Cleveland.
1984 ◽
Vol 52
(03)
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pp. 221-223
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1984 ◽
Vol 56
(3)
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pp. 666-670
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1977 ◽
Vol 60
(3)
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pp. 584-594
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1983 ◽
Vol 258
(24)
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pp. 15079-15086
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1992 ◽
Vol 267
(6)
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pp. 4247-4252
2009 ◽
Vol 20
(3)
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pp. 323-328
1998 ◽
Vol 80
(07)
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pp. 24-27
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1990 ◽
Vol 98
(1)
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pp. 67-73
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1985 ◽
Vol 260
(23)
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pp. 12434-12443
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