scholarly journals Renal sodium handling and neurohumoral systems in patients with cirrhosis in sitting posture: effects of spironolactone and water immersion

1993 ◽  
Vol 71 (11) ◽  
Author(s):  
A.L. Gerbest ◽  
A. Pilzt ◽  
H. Wernze ◽  
D. J�ngst
Keyword(s):  
Water Immersion ◽  
Sitting Posture ◽  
Renal Sodium Handling ◽  
Sodium Handling

Relationship between Urinary Kallikrein and Renal Sodium Handling during Water Immersion in Normal Man*

1980 ◽  
Vol 50 (1) ◽  
pp. 122-127 ◽  
Author(s):  
MURRAY EPSTEIN ◽  
RICHARD A. STONE ◽  
ARTHUR G. DENUNZIO ◽  
RONALD P. FRIGON
Keyword(s):  
Water Immersion ◽  
Urinary Kallikrein ◽  
Normal Man ◽  
Renal Sodium Handling ◽  
Sodium Handling

scholarly journals Relationship between renal prostaglandin E and renal sodium handling during water immersion in normal man.

1979 ◽  
Vol 45 (1) ◽  
pp. 71-80 ◽  
Author(s):  
M Epstein ◽  
M D Lifschitz ◽  
D S Hoffman ◽  
J H Stein
Keyword(s):  
Water Immersion ◽  
Prostaglandin E ◽  
Normal Man ◽  
Renal Sodium Handling ◽  
Sodium Handling

Characterization of Renal Prostaglandin E Responsiveness in Decompensated Cirrhosis: Implications for Renal Sodium Handling

1982 ◽  
Vol 63 (6) ◽  
pp. 555-563 ◽  
Author(s):  
Murray Epstein ◽  
Meyer Lifschitz ◽  
M. Ramachandran ◽  
Kenneth Rappaport
Keyword(s):  
Renal Function ◽  
Water Immersion ◽  
Normal Subjects ◽  
Decompensated Cirrhosis ◽  
Prostaglandin E ◽  
Prostaglandin Synthase ◽  
Endogenous Prostaglandins ◽  
Cirrhotic Patients ◽  
Renal Sodium Handling ◽  
Sodium Handling

1. It has been suggested that endogenous renal prostaglandin E (PGE) constitutes a determinant of renal haemodynamics and renal sodium handling in patients with cirrhosis. We have accordingly assessed the effects of augmenting endogenous prostaglandins on renal function. We utilized water immersion to the neck since previous studies demonstrated that the redistribution of blood volume and concomitant central hypervolaemia thus induced produces a prompt and marked augmentation of PGE excretion in normal man. 2. Thirteen cirrhotic patients were studied twice while in balance on a daily 10 mmol of sodium/100 mmol of potassium diet during control and during water immersion. Urinary PGE was determined hourly for 6 h. 3. Cirrhotic patients manifested a wide continuum of responses characterized by either a sluggish or barely discernible natriuretic response (n = 5) or an appropriate natriuretic response (n = 8). 4. Water immersion to the neck resulted in a highly significant increase in mean UPGEV, which was threefold that manifested by normal subjects studied under identical conditions. Furthermore, cumulative sodium excretion during immersion correlated with PGE excretion (P < 0·05). 5. These findings, together with the results of studies utilizing prostaglandin synthase inhibitors, are consistent with the postulate that renal PGE may play a role in the alterations of renal function in decompensated cirrhosis.

Renal sodium handling in acute and chronic salt loading/depletion protocols

2000 ◽  
Vol 18 (11) ◽  
pp. 1657-1664 ◽  
Author(s):  
Michel Burnier ◽  
Marie-Laure Monod ◽  
Arnaud Chioléro ◽  
Marc Maillard ◽  
Jurg Nussberger ◽  
...  
Keyword(s):  
Salt Loading ◽  
Renal Sodium Handling ◽  
Sodium Handling

Renal Sodium Handling in Relation to Environmental and Genetic Factors in Untreated Chinese

2020 ◽  
Author(s):  
Yuan-Yuan Kang ◽  
Yi-Bang Cheng ◽  
Qian-Hui Guo ◽  
Chang-Sheng Sheng ◽  
Qi-Fang Huang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multiple Testing ◽  
Genetic Factors ◽  
Blood Pressure Monitoring ◽  
Lithium Concentration ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Renal Sodium Handling ◽  
Renal Tubular ◽  
Sodium Handling

Abstract Background We investigated proximal and distal renal tubular sodium handling, as assessed by fractional excretion of lithium (FELi) and fractional distal reabsorption rate of sodium (FDRNa), in relation to environmental and genetic factors in untreated patients. Methods Our study participants were suspected hypertensive patients being off antihypertensive medication for ≥2 weeks and referred for 24-hour ambulatory blood pressure monitoring. We collected serum and 24-hour urine for measurement of sodium, creatinine and lithium concentration, and calculated FELi and FDRNa. We genotyped 19 SNPs associated with renal sodium handling or blood pressure using the ABI SNapShot method. Results The 1409 participants (664 men, 47.1%) had a mean (±SD) age of 51.0±10.5 years. After adjustment for host factors, both FELi and FDRNa were significantly (P≤0.01) associated with season and humidity, explaining ~1.3% and ~3.5% of the variance, respectively. FELi was highest in autumn and lowest in summer and intermediate in spring and winter (P=0.007). FDRNa was also highest in autumn but lowest in winter and intermediate in spring and summer (P&lt;0.001). Neither FELi nor FDRNa was associated with outdoor temperature or atmospheric pressure (P≥0.13). After adjustment for host and environmental factors and Bonferroni multiple testing, among the 19 studied genetic variants, only rs12513375 was significantly associated with FELi and FDRNa (P≤0.004) and explained about 1.7% of the variance. Conclusions Renal sodium handling as measured by endogenous lithium clearance was sensitive to major environmental and genetic factors. Our finding is towards the use of these indexes for the definition of renal tubular dysfunction.

Effects of insulin and lipid emulsion on renal haemodynamics and renal sodium handling in IDDM patients

Diabetologia ◽  
1996 ◽  
Vol 39 (9) ◽  
pp. 1074-1082 ◽  
Author(s):  
T. Pelikánová ◽  
I. Smrčková ◽  
J. KŘíŽová ◽  
J. StŘíbrná ◽  
V. Lánská
Keyword(s):  
Lipid Emulsion ◽  
Renal Haemodynamics ◽  
Renal Sodium Handling ◽  
Sodium Handling
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