scholarly journals Increased Extracellular K + Concentration Reduces the Efficacy of N -methyl- d -aspartate Receptor Antagonists to Block Spreading Depression-Like Depolarizations and Spreading Ischemia

Stroke ◽  
2005 ◽  
Vol 36 (6) ◽  
pp. 1270-1277 ◽  
Author(s):  
Gabor C. Petzold ◽  
Olaf Windmüller ◽  
Stephan Haack ◽  
Sebastian Major ◽  
Katharina Buchheim ◽  
...  
Keyword(s):  
Spreading Depression ◽  
Receptor Antagonists ◽  
Aspartate Receptor ◽  
K Concentration

N-methyl-d-aspartate receptor antagonists for migraine: A potential therapeutic approach

2009 ◽  
Vol 72 (5) ◽  
pp. 603-605 ◽  
Author(s):  
Ruidong Ye ◽  
Xiangwei Kong ◽  
Junliang Han ◽  
Gang Zhao
Keyword(s):  
Therapeutic Approach ◽  
Receptor Antagonists ◽  
Aspartate Receptor

scholarly journals Potential anti-cancer effects of N-methyl-d-aspartate receptor antagonists in vitro

2019 ◽  
Vol 123 (4) ◽  
pp. e498-e499
Author(s):  
Junichi Saito ◽  
Hailin Zhao ◽  
Masae Iwasaki ◽  
Lingzhi Wu ◽  
Cong Hu ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Aspartate Receptor ◽  
Anti Cancer

scholarly journals Suppression of Spreading Depression of Leão in Neocortex by an N-Methyl-D-Aspartate Receptor Antagonist

1992 ◽  
Vol 19 (4) ◽  
pp. 487-491 ◽  
Author(s):  
Richard S. McLachlan
Keyword(s):  
Receptor Antagonist ◽  
Spreading Depression ◽  
Excitatory Amino Acid ◽  
Mean Amplitude ◽  
Nmda Receptor Antagonist ◽  
Chemical Stimulation ◽  
Critical Element ◽  
Rate Of Spread ◽  
Interictal Spike ◽  
Aspartate Receptor

ABSTRACT:Spreading depression has been implicated in the pathophysiology of a number of diseases such as migraine, stroke and epilepsy. The characteristics of this phenomenon were explored in neocortex of anesthetized rats. Spreading depression was produced in 10 of 15 animals using mechanical, electrical and chemical stimulation. Mean amplitude of the DC shift was -9.3 mV, mean duration at any one electrode 65 sec and rate of spread 2-5 mm/min. Spreading depression was facilitated by focal interictal spike activity induced by penicillin and completely blocked by the N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-aminophosphonovaleric acid (APV), providing further evidence that excitatory amino acid neurotransmission is a critical element in the development or propagation of the phenomenon.

Regioselective Preparation of Functionalized Isoxazoline Derivatives as Key Intermediates for the Synthesis of Selective N-Methyl-d-aspartate Receptor Antagonists

Synthesis ◽  
2011 ◽  
Vol 2011 (08) ◽  
pp. 1255-1260 ◽  
Author(s):  
Lucia Tamborini ◽  
Andrea Pinto ◽  
Paola Conti ◽  
Maddalena Gallanti ◽  
Maria Iannuzzi ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Aspartate Receptor
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