Vasomotor Reactivity and Pattern of Collateral Blood Flow in Severe Occlusive Carotid Artery Disease

Stroke ◽  
1996 ◽  
Vol 27 (2) ◽  
pp. 296-299 ◽  
Author(s):  
M. Müller ◽  
K. Schimrigk
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Collateral Blood Flow ◽  
Vasomotor Reactivity ◽  
Artery Disease

scholarly journals Relationship between haemodynamic impairment and collateral blood flow in carotid artery disease

2017 ◽  
Vol 38 (11) ◽  
pp. 2021-2032 ◽  
Author(s):  
Nolan S Hartkamp ◽  
Esben T Petersen ◽  
Michael A Chappell ◽  
Thomas W Okell ◽  
Maarten Uyttenboogaart ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Tissue Level ◽  
Cerebrovascular Reactivity ◽  
Collateral Flow ◽  
Collateral Blood Flow ◽  
Ischaemic Damage ◽  
Before And After ◽  
Artery Disease

Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was to investigate the effect of carotid artery disease upon cerebral perfusion and cerebrovascular reactivity and whether haemodynamic impairment is influenced at brain tissue level by the existence of primary and/or secondary collateral. Eighty-eight patients with steno-occlusive ICA disease and 29 healthy controls underwent MR examination. The presence of collaterals was determined with time-of-flight, two-dimensional phase contrast MRA and territorial arterial spin labeling (ASL) imaging. Cerebral blood flow and cerebrovascular reactivity were assessed with ASL before and after acetazolamide. Cerebral haemodynamics were normal in asymptomatic ICA stenosis patients, as opposed to patients with ICA occlusion, in whom the haemodynamics in both hemispheres were compromised. Haemodynamic impairment in the affected brain region was always present in symptomatic patients. The degree of collateral blood flow was inversely correlated with haemodynamic impairment. Recruitment of secondary collaterals only occurred in symptomatic ICA occlusion patients. In conclusion, both CBF and cerebrovascular reactivity were found to be reduced in symptomatic patients with steno-occlusive ICA disease. The presence of collateral flow is associated with further haemodynamic impairment. Recruitment of secondary collaterals is associated with severe haemodynamic impairment.

Color Doppler Imaging Provides Accurate Assessment of Orbital Blood Flow in Occlusive Carotid Artery Disease

Ophthalmology ◽  
1991 ◽  
Vol 98 (4) ◽  
pp. 548-552 ◽  
Author(s):  
Wolfgang E. Lieb ◽  
Patrick M. Flaharty ◽  
Robert C. Sergott ◽  
Rickey D. Medlock ◽  
Gary C. Brown ◽  
...  
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Color Doppler ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Accurate Assessment ◽  
Artery Disease

scholarly journals Changes in Blood Flow and Oxygen Metabolism During Visual Stimulation in Carotid Artery Disease

Stroke ◽  
2002 ◽  
Vol 33 (5) ◽  
pp. 1294-1300 ◽  
Author(s):  
Hiroshi Yamauchi ◽  
Hidehiko Okazawa ◽  
Yoshihiko Kishibe ◽  
Kanji Sugimoto ◽  
Masaaki Takahashi
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Visual Stimulation ◽  
Carotid Artery Disease ◽  
Oxygen Metabolism ◽  
Artery Disease

Abstract 204: Regional Hypoperfusion is Associated with Cortical Thinning in Asymptomatic Carotid Artery Disease

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Randolph S Marshall ◽  
Iris Asllani ◽  
MaryKay Pavol ◽  
Pamelia Slattery ◽  
Ronald Lazar
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Cortical Thickness ◽  
Primary Motor Cortex ◽  
Carotid Artery Disease ◽  
Brodmann Area ◽  
Symptomatic Carotid ◽  
Cortical Thinning ◽  
Artery Disease ◽  
Definition Of

Objective: Cortical thinning has been reported in patients with cerebrovascular disease and degenerative dementia, but the direct impact of regional hypoperfusion on cortical pathology has been difficult to establish. We examined the association between regional cerebral blood flow (rCBF) and regional cortical thickness (rCT) in a cohort of patients with unilateral high-grade internal carotid artery (ICA) disease without history of stroke. Methods: Twenty-seven patients age 73±10yrs, 11F with unilateral ICA stenosis ≥80% or occlusion but no stroke underwent MRI, including high resolution T1 (MPRAGE) and tissue specific pseudocontinuous arterial spin labeling (ts-pCASL) to assess cortical thickness and gray matter resting CBF. Cortical thickness was measured in each hemisphere in the primary motor cortex (M1--Brodmann Area 4) by a blinded investigator using Freesurfer software ( http://surfer.nmr.mgh.harvard.edu/ ), and in visual cortex (V1, Brodmann area 17) as a control for nonspecific effects in the posterior circulation. Paired t-tests were used to assess hemispheral asymmetry for rCBF and for rCT in M1 on the occluded vs unoccluded side. Linear regression was used to predict the effect of rCBF on rCT in M1 on the occluded side. Results: Cortex was 0.08mm thinner on the side of ICA occlusion in M1 (95%CI=0.04-0.11, p=0.0003). There was no rCT asymmetry in V1 (p=.276). rCBF was 9.3 ml/100gm*min -1 lower in M1 of the occluded hemisphere (95%CI=5.1-13.5, p<.0001). Cortical blood flow in M1 was a significant predictor of cortical thickness in M1 on the side of the occluded ICA (adj R 2 =.128, p=.038). Conclusion: Cortical thinning occurred in M1 on the side of carotid occlusion in the absence of stroke, and correlated with lower rCBF. Brodmann area 4 was chosen to represent the distal field of the carotid artery. Our finding demonstrates an important effect of chronically reduced blood flow on brain pathology, and suggests that a broader definition of “symptomatic” carotid artery disease may be needed.

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