scholarly journals Diffusion-Weighted Magnetic Resonance Imaging Confirms Marked Neuroprotective Efficacy of Albumin Therapy in Focal Cerebral Ischemia

Stroke ◽  
1998 ◽  
Vol 29 (12) ◽  
pp. 2587-2599 ◽  
Author(s):  
Ludmila Belayev ◽  
Weizhao Zhao ◽  
Pradip M. Pattany ◽  
R. Greg Weaver ◽  
Pil W. Huh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Focal Cerebral Ischemia ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
Neuroprotective Efficacy ◽  
Albumin Therapy

Acute focal cerebral ischemia in rats studied by diffusion-weighted magnetic resonance imaging—An experimental study

1996 ◽  
Vol 46 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Ryoji Kimura ◽  
Akihiko Shiino ◽  
Masayuki Matsuda ◽  
Jyoji Handa ◽  
Shigehiro Morikawa ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Experimental Study ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Focal Cerebral Ischemia ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging

Temporal evolution of focal cerebral ischemia in the rat assessed by T2-weighted and diffusion-weighted magnetic resonance imaging

1992 ◽  
Vol 5 (2) ◽  
pp. 171-176 ◽  
Author(s):  
H. B. Verheul ◽  
J. W. Berkelbach van der Sprenkel ◽  
C. A. F. Tulleken ◽  
K. S. Tamminga ◽  
K. Nicolay
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Temporal Evolution ◽  
Focal Cerebral Ischemia ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging ◽  
And Diffusion

T2*-weighted magnetic resonance imaging of cerebrovascular reactivity in rat reversible focal cerebral ischemia

1997 ◽  
Vol 744 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Yasuki Ono ◽  
Shigehiro Morikawa ◽  
Toshiro Inubushi ◽  
Hiroaki Shimizu ◽  
Takashi Yoshimoto
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Focal Cerebral Ischemia ◽  
Cerebrovascular Reactivity ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging

Detection of perioperative cerebral ischemia by means of diffusion-weighted magnetic resonance imaging

2001 ◽  
Vol 6 (1) ◽  
pp. 5-8
Author(s):  
F. Liewald ◽  
R. Tomczak ◽  
G. Halter ◽  
J. Görich ◽  
G. Stuber ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging

scholarly journals Polynitroxyl Albumin Reduces Infarct Size in Transient Focal Cerebral Ischemia in the Rat: Potential Mechanisms Studied by Magnetic Resonance Imaging

1998 ◽  
Vol 18 (9) ◽  
pp. 1022-1031 ◽  
Author(s):  
Christian Beaulieu ◽  
Elmar Busch ◽  
Joachim Röther ◽  
Alexander de Crespigny ◽  
Carleton J. C. Hsia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Middle Cerebral Artery ◽  
Diffusion Weighted Imaging ◽  
Focal Cerebral Ischemia ◽  
Treated Group ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Transient Focal Cerebral Ischemia

Nitroxide free radicals are known to protect cells from oxidative damage. Diffusion-weighted and perfusion-weighted magnetic resonance imaging was used to evaluate the effects of polynitroxyl albumin(PNA) in a middle cerebral artery intraluminal suture model of transient focal cerebral ischemia in the rat. Three groups of Sprague-Dawley rats were investigated: (1) PNA(N = 6), (2) human serum albumin (N = 6), and (3) saline (N = 7). The middle cerebral artery was occluded for 2 hours. Treatment was started 30 minutes after induction of ischemia. A total dose of 1% body weight (volume/weight) of PNA (23.5 mg/dL protein and 110 mmol/L nitroxide), albumin (23.5 mg/dL), or saline was injected intravenously at three time points: 0.5% at 0.5 hours, 0.25% at 2 hours (i.e., just before reperfusion), and 0.25% at 4 hours after occlusion. Six sets of diffusion- and perfusion-weighted magnetic resonance images were acquired throughout the 2 hours of ischemia and the 2 hours of reperfusion. The rats were killed at 24 hours, and the brains were stained with 2,3,5-triphenyltetrazolium chloride (TTC). Diffusion-weighted imaging showed that the growth of the ischemic lesion was suppressed in the PNA-treated group. The 4 hours diffusion-weighted imaging-derived hemispheric lesion volume in the PNA-treated group (25% ± 9%) was significantly smaller than that in the saline-treated(43% ± 13%; P = 0.016) or albumintreated groups (38% ± 6%; P = 0.017). A larger difference was observed for the 24-hour TTC-derived lesion volumes in the PNA (8% ± 7%), saline (35% ± 8%; P< 0.001), and albumin (31% ± 6%; P < 0.001) groups. Perfusion-weighted imaging demonstrated a marked improvement in cerebral perfusion in the PNA-treated group during ischemia and reperfusion. In conclusion, treatment with PNA results in an improvement in perfusion and a reduction of infarct volume in a model of transient focal cerebral ischemia in the rat.

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