Abstract 18375: Urinary Liver Fatty-acid Binding Protein Within 24 Hours from Contrast Media Exposure May Predict Acute Kidney Injury

Introduction: Contrast-induced acute kidney injury (CI-AKI) is one of major complication of contrast medium exposure. However, few biological markers the day after contrast media exposure rapidly predict CI-AKI. Urinary liver fatty-acid binding protein (L-FABP), as a novel marker of renal ischemia and stress, has been reported to elevate in CI-AKI. Hypothesis: We tested the hypothesis that L-FABP within 24 hours from contrast media procedure predicted CI-AKI. Methods: A total of 160 patients who underwent invasive catheterization or coronary CT angiography were examined the study. Urinary liver fatty-acid binding protein within a day after the procedure was measured. Serum creatinine level within 72 hours were compared to baseline. CI-AKI was defined as laboratory increase of serum creatinine value =25% or >=0.5mg/dl from baseline at 72 hours. Results: Estimated glomerular filtration rate of all patients averaged 69±24 ml/min/1.73m2. L-FABP level averaged 11.9±27μg /gCr. On receiver operating characteristics (ROC) analysis, cut-off value was 14.3μg /gCr and the area under the curve (AUC) was 0.739 (95 % CI: 0.576-0.902, P = 0.01). Negative predictive value for predicting CI-AKI was 0.99. Conclusions: L-FABP within 24 hours from contrast media procedure may predict CI-AKI with quite high negative predictive value.