Abstract P166: Plasma Acylcarnitines During Pregnancy And Neonatal Anthropometry: A Prospective And Longitudinal Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Yiqing Song ◽  
Chen Lyu ◽  
Ming Li ◽  
Mohammad Rahman ◽  
Yeyi Zhu ◽  
...  
Keyword(s):  
Generalized Linear Models ◽  
Clinical Utility ◽  
Latent Class ◽  
Linear Models ◽  
Distinct Group ◽  
Blood Collection ◽  
Z Score ◽  
Cardiometabolic Disorders ◽  
Trajectory Approach

As surrogate readouts reflecting tissue acyl-CoA pools, elevated levels of plasma acylcarnitines have been associated with cardiometabolic disorders, such as obesity, gestational diabetes, and type 2 diabetes. This study aimed to examine prospective associations of acylcarnitine profiles across gestation with neonatal anthropometry, including birthweight (BW), BW z-score, the sum of skinfolds (SS), body length, and head circumference. We quantified 28 acylcarnitines using electrospray ionization tandem mass spectrometry in plasma collected at gestational weeks 10-14, 15-26, 23-31 and 33-39 among 321 pregnant women from the NICHD Fetal Growth Studies-Singletons and performed latent-class trajectory approach to identify trajectories of acylcarnitines across gestation. We examined the associations of individual acylcarnitines and distinct trajectory groups with neonatal outcomes using weighted generalized linear models adjusting for maternal age, race, education, parity, gestational age of blood collection, and pre-pregnancy BMI. Women showed changes in plasma levels of all acylcartinines across gestation and had at least two significantly distinct group-based trajectories for 32% of acylcartinines. Longitudinally, women with increased C12 levels across gestation (5.7%) had significantly smaller BW (-475 g; 95% CI, -942, -6.79), BW z-score (-0.39, 95% CI, -0.71, -0.06), and length (-1.38, 95% CI, -2.49, -0.27) than those with persistently stable C12 levels during pregnancy (all FDR<0.05). Women with persistently higher levels of C10 (6.1%) or C10:1 (87.4%) had greater sum of skinfolds (4.91, 95%, 0.85, 8.98) than those with lower levels during pregnancy (P<0.05). In conclusion, this study identified that gestational trajectories of C10, C10:1, and C12 acylcarnitine levels were significantly associated with neonatal anthropometry. Further studies are needed to replicate and assess clinical utility of these findings.

scholarly journals Plasma Acylcarnitines during Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 885
Author(s):  
Yiqing Song ◽  
Chen Lyu ◽  
Ming Li ◽  
Mohammad L. Rahman ◽  
Zhen Chen ◽  
...  
Keyword(s):  
Latent Class ◽  
Linear Models ◽  
P Value ◽  
Blood Collection ◽  
Z Score ◽  
Cardiometabolic Disorders ◽  
Trajectory Approach ◽  
Body Circumferences ◽  
Lower Birthweight

As surrogate readouts reflecting mitochondrial dysfunction, elevated levels of plasma acylcarnitines have been associated with cardiometabolic disorders, such as obesity, gestational diabetes, and type 2 diabetes. This study aimed to examine prospective associations of acylcarnitine profiles across gestation with neonatal anthropometry, including birthweight, birthweight z score, body length, sum of skinfolds, and sum of body circumferences. We quantified 28 acylcarnitines using electrospray ionization tandem mass spectrometry in plasma collected at gestational weeks 10–14, 15–26, 23–31, and 33–39 among 321 pregnant women from the National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies-Singletons. A latent-class trajectory approach was applied to identify trajectories of acylcarnitines across gestation. We examined the associations of individual acylcarnitines and distinct trajectory groups with neonatal anthropometry using weighted generalized linear models adjusting for maternal age, race/ethnicity, education, parity, gestational age at blood collection, and pre-pregnancy body mass index (BMI). We identified three distinct trajectory groups in C2, C3, and C4 and two trajectory groups in C5, C10, C5–DC, C8:1, C10:1, and C12, respectively. Women with nonlinear decreasing C12 levels across gestation (5.7%) had offspring with significantly lower birthweight (−475 g; 95% CI, −942, −6.79), birthweight z score (−0.39, −0.71, −0.06), and birth length (−1.38 cm, −2.49, −0.27) than those with persistently stable C12 levels (94.3%) (all nominal p value < 0.05). Women with consistently higher levels of C10 (6.1%) had offspring with thicker sum of skinfolds (4.91 mm, 0.85, 8.98) than did women with lower levels (93.9%) during pregnancy, whereas women with lower C10:1 levels (12.6%) had offspring with thicker sum of skinfolds (3.23 mm, 0.19, 6.27) than did women with abruptly increasing levels (87.4%) (p < 0.05). In conclusion, this study suggests that distinctive trajectories of C10, C10:1, and C12 acylcarnitine levels throughout pregnancy were significantly associated with neonatal anthropometry.

scholarly journals Plasma Acylcarnitines During Pregnancy and Neonatal Anthropometry: A Longitudinal Study in a Multiracial Cohort

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 778-778
Author(s):  
Chen Lyu ◽  
Yiqing Song ◽  
Ming Li ◽  
Mohammad Rahman ◽  
Yeyi Zhu ◽  
...  
Keyword(s):  
Latent Class ◽  
Linear Models ◽  
Blood Collection ◽  
Z Score ◽  
Funding Sources ◽  
Trajectory Approach ◽  
Gestational Week ◽  
Potential Clinical Utility ◽  
Race Ethnicity ◽  
Plasma Profile

Abstract Objectives Plasma profile of acylcarnitines has been suggested to associate with adverse maternal outcomes such as gestational diabetes. However, data on their associations with neonatal outcomes are sparse. Therefore, this study aimed to examine the prospective profile of acylcarnitines across gestation and its association with neonatal anthropometry, including birthweight (BW), BW z-score, the sum of skinfolds (SSF), length, and circumferences. Methods Among 321 pregnant women from the NICHD Fetal Growth Studies-Singletons cohort, we quantified 28 acylcarnitines using electrospray ionization tandem mass spectrometry in the plasma at gestational weeks 10–14, 15–26, 23–31 and 33–39, accordingly. We firstly applied a latent-class trajectory approach to identify trajectories of acylcarnitines across gestation, and secondly examined associations of individual acylcarnitine and distinct trajectory groups with neonatal anthropometry using weighted linear models with robust standard errors, adjusting for maternal age, race/ethnicity, education, parity, gestational week of blood collection, and pre-pregnancy body mass index. Results We identified three distinct trajectory groups of C2, C3 and C4, and two trajectory groups of C5, C10, C5-DC, C8:1, C10:1 and C12, respectively. Newborns of women with nonlinear decline of C12 levels across gestation (5.7%) had significantly smaller BW (−475 g; 95% CI: −942, −6.79 g), BW z-score (−0.39; −0.71, −0.06), and length (−1.38 cm; −2.49, −0.27 cm) than those with persistently stable C12 levels (94.3%). Newborns of women with consistently higher levels of C10 (6.1%) had greater sum of skinfolds (4.91 mm; 0.85, 8.98 mm) than those with lower levels (93.9%) across pregnancy, whereas newborns of women with declining C10:1 levels (12.6%) had larger sum of skinfolds (3.23 mm; 0.19, 6.27 mm) than those with abruptly increasing levels (87.4%). Conclusions In conclusion, gestational trajectories of C10, C10:1, and C12 acylcarnitine levels were significantly associated with neonatal anthropometry. Further studies are needed to verify and further explore the potential clinical utility of these findings. Funding Sources Eunice Kennedy Shriver National Institute of Child Health and Human Development intramural funding; American Recovery and Reinvestment Act funding.

scholarly journals Association between dietary salt and plasma glucose, insulin and hemoglobin A1C levels among type 2 diabetes patients in Eastern China

2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Generalized Linear Models ◽  
Plasma Glucose ◽  
Hemoglobin A1c ◽  
Linear Models ◽  
Salt Intake ◽  
Eastern China ◽  
Dietary Salt ◽  
Dietary Salt Intake

Abstract Purpose Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients. Methods Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association. Results A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt > 8g/d were positively associated with FPG and HbA1c. Conclusion Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.

Abstract P171: A Longitudinal Study Of Maternal Thyroid Hormone Trajectories And Neonatal Anthropometric Measures

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Shristi Rawal ◽  
Lauren Berube ◽  
Stefanie Hinkle ◽  
Jing Wu ◽  
Cuilin Zhang
Keyword(s):  
Thyroid Hormones ◽  
Fetal Growth ◽  
Latent Class ◽  
Blood Collection ◽  
Z Score ◽  
Linear Regression Models ◽  
Anthropometric Measures ◽  
Infant Sex ◽  
Maternal Thyroid ◽  
In Pregnancy

Introduction: Maternal thyroid hormones (TH) are essential for fetal growth and development. While prior studies have examined associations of TH with birthweight (BW), data on other neonatal anthropometric measures are scarce. Here we aimed to examine relations between TH and its trajectory across pregnancy with neonatal anthropometrics in a multi-racial pregnancy cohort. Hypothesis: We hypothesized that distinct TH trajectories across gestation would explain differences in neonatal anthropometrics including BW, length and sum of skinfolds (SSF). Methods: We used longitudinal data from 321 women who were included in a gestational diabetes (GDM) case-control study nested within the NICHD Fetal Growth Studies-Singletons Cohort (n=2802). Plasma free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) were measured, and fT3/fT4 ratio was derived, using blood samples collected at gestational weeks (GW) 10-14, 15-26, 23-31 and 33-39. TH trajectories were identified using a latent class trajectory approach. BW was abstracted from medical records. Neonatal length and SSF were measured. To examine associations between TH levels and neonatal outcomes, we used weighted linear regression models, adjusted for maternal age, race/ethnicity, GW at blood collection, pre-pregnancy BMI, education, parity, infant sex, GDM diagnosis (33-39 GW only) and number of days post-delivery (length and SSF only). Results: Overall, neonates of women in the highest fT3 tertile at 33-39 GW had marginally higher BW (β: 205.5 g, 95% CI -23.4, 434.4) and BW z-score (β: 0.4, 95% CI 0.0, 0.8) than neonates of women in the lowest tertile. Significant interactions were observed by infant sex for associations of fT4 and BW, BW z-score and neonatal length (all p for interactions <0.05). Specifically, female neonates of women in the highest fT4 tertile had lower BW, BW z-score and length than those in the lowest tertile at 15-26 (β BW -416.3 g, 95% CI -753.7, -79.0; β BW zscore -0.5, 95% CI -0.9, -0.1; β length -1.5 cm, 95% CI -2.8, -0.1, respectively) and 23-31 GW (β BW -357.0 g, 95% CI -635.6, -78.4; β BW zscore -0.7, 95% CI -1.3, -0.1; β length -1.8 cm, 95% CI -3.3, -0.2, respectively). Across gestation, a low fT3 trajectory (class size 5.5%) was associated with lower neonatal SSF (β: -3.2 mm, 95% CI -6.0, -0.5) than an intermediate/referent trajectory (60.1%). A high fT3/fT4 ratio trajectory (16.2%) was associated with higher BW (β: 300.5 g, 95% CI 41.7, 559.4), BW z-score (β: 0.6, 95% CI 0.3, 0.8), and neonatal SSF (β: 3.3 mm, 95% CI 0.7, 5.9) than an intermediate/referent trajectory (44.3%). Conclusions: Our study suggests that both overall TH trajectory across gestation and TH levels at specific timepoints in pregnancy may be related to neonatal anthropometrics, with associations varying by infant sex. These novel data support the significance of monitoring thyroid hormones longitudinally in pregnancy.

Random Effects Models for Personal Networks

Methodology ◽  
2006 ◽  
Vol 2 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Jeroen K. Vermunt ◽  
Matthijs Kalmijn
Keyword(s):  
Marital Status ◽  
Random Effects ◽  
Generalized Linear Models ◽  
Latent Class ◽  
Linear Models ◽  
Personal Networks ◽  
Outcome Variable ◽  
Random Effects Models ◽  
Categorical Response ◽  
Age Category

We propose analyzing personal or ego-centered network data by means of two-level generalized linear models. The approach is illustrated with an example in which we assess whether personal networks are homogenous with respect to marital status after controlling for age homogeneity. In this example, the outcome variable is a bivariate categorical response variable (alter’s marital status and age category). We apply both factor-analytic parametric and latent-class-based nonparametric random effects models and compare the results obtained with the two approaches. The proposed models can be estimated with the Latent GOLD program for latent class analysis.

scholarly journals Association between dietary salt and plasma glucose, insulin and hemoglobin A1C levels among type 2 diabetes patients in Eastern China

2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik Chattopadhyay ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Generalized Linear Models ◽  
Plasma Glucose ◽  
Hemoglobin A1c ◽  
Linear Models ◽  
Salt Intake ◽  
Eastern China ◽  
Dietary Salt ◽  
Dietary Salt Intake

Abstract Purpose: Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients.Methods: Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association.Results: A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt >8g/d were positively associated with FPG and HbA1c.Conclusion: Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.

scholarly journals Association between dietary salt and plasma glucose, insulin and hemoglobin A1C levels among type 2 diabetes patients in Eastern China

2021 ◽  
Author(s):  
Yi Lin ◽  
Kaushik ◽  
Xi Yang ◽  
Jia-Lin Li ◽  
Yan-Shu Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Generalized Linear Models ◽  
Plasma Glucose ◽  
Hemoglobin A1c ◽  
Linear Models ◽  
Salt Intake ◽  
Eastern China ◽  
Dietary Salt ◽  
Dietary Salt Intake

Abstract Purpose Type 2 diabetes (T2D) is one of the major public health concerns in China. Studies on the association between dietary salt intake and the glycaemia response of T2D are lacking in China. The aim was to investigate the association between the levels of dietary salt intake and the plasma glucose, insulin and hemoglobin A1c (HbA1c) in T2D patients. Methods Patients with T2D, who accepted management and treatment by the National Standardized Metabolic Disease Management Center at Ningbo First Hospital from March 2018 to January 2020, were included in this study. Dietary salt was collected through a standardized food frequent questionnaire. Anthropometry, blood pressure and biomarkers were measured by well-trained endocrinology nurses. Generalized linear models (GLM) were used to examine the association. Results A total of 1145 eligible T2D patients with the mean age of 51.4 years were included in the study. Fasting plasma glucose (FPG), 2h postprandial plasma glucose and 2h postprandial insulin, were significantly increased across dietary salt categories. Generalized linear models further showed that dietary salt > 8g/d were positively associated with FPG and HbA1c. Conclusion Higher daily salt intake was found to be associated with FPG and HbA1c in T2D patients. Lifestyle education and promotion on salt reduction should be provided to T2D patients.

A form of Autoimmune Diabetes in Adults Named LADA – An Update on Essential Features and Controversies

2019 ◽  
Vol 15 (3) ◽  
pp. 172-173 ◽  
Author(s):  
Valdemar Grill ◽  
Bjørn O. Åsvold
Keyword(s):  
Genetic Background ◽  
Clinical Utility ◽  
Autoimmune Diabetes ◽  
Classical Type ◽  
Phenotypic Characteristics ◽  
Latent Autoimmune Diabetes ◽  
The Impact

Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis has been challenged. Despite the absence of a genetic background that is exclusive to LADA, this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems as to therapy and follow-up perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.

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