scholarly journals Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury

Circulation ◽  
2008 ◽  
Vol 117 (9) ◽  
pp. 1153-1160 ◽  
Author(s):  
Matthias Nahrendorf ◽  
David Sosnovik ◽  
John W. Chen ◽  
Peter Panizzi ◽  
Jose-Luiz Figueiredo ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Imaging Agent ◽  
Myeloperoxidase Activity ◽  
Resonance Imaging ◽  
Antiinflammatory Effects ◽  
Magnetic Resonance Imaging Agent

scholarly journals Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 775
Author(s):  
Per Mose Nielsen ◽  
Christian Østergaard Mariager ◽  
Daniel Guldager Kring Rasmussen ◽  
Marie Mølmer ◽  
Federica Genovese ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
T2 Mapping ◽  
Ischemia Reperfusion ◽  
Quantitative Polymerase Chain Reaction ◽  
Type Iii Collagen ◽  
Resonance Imaging ◽  
Dce Mri

Fibrosis is often heterogeneously distributed, and classical biopsies do not reflect this. Noninvasive methods for renal fibrosis have been developed to follow chronic kidney diseases (CKD) and to monitor anti-fibrotic therapy. In this study, we combined two approaches to assess fibrosis regression following renal ischemia-reperfusion injury (IRI): magnetic resonance imaging (MRI) and noninvasive extracellular matrix (ECM) biomarkers. MRI was used to evaluate fibrosis in bilateral IRI in rats after reperfusion at 7, 14, and 21 days. This was performed with 1HT1 and T2* mapping, dynamic contrast-enhanced (DCE)-MRI, and chemical shift imaging (CSI)-23Na. The degradation of laminin gamma-1 chain (LG1M) and type III collagen (C3M) was measured in urine and plasma. Fibrosis was analyzed in tissue using fibronectin (FN) and alpha-smooth muscle actin (α-SMA) using quantitative polymerase chain reaction qPCR and western blotting. We found increased fibrosis 7 days after reperfusion, which dropped to sham levels after 21 days. Single kidney glomerular filtration rate (skGFR), perfusion (DCE-MRI), and total 23Na kidney content correlated positively with fibrotic markers FN and α-SMA as well as noninvasive LG1M and C3M. We showed that novel MRI protocols and ECM markers could track fibrogenic development. This could give rise to a multi-parametric practice to diagnose and assess fibrosis whilst treating kidney disease without using invasive methods.

Sonochemically produced fluorocarbon microspheres: A new class of magnetic resonance imaging agent

1996 ◽  
Vol 6 (4) ◽  
pp. 675-683 ◽  
Author(s):  
Andrew G. Webb ◽  
Mike Wong ◽  
Kenneth J. Kolbeck ◽  
Richard L. Magin ◽  
Kenneth S. Suslick
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Imaging Agent ◽  
Resonance Imaging ◽  
New Class ◽  
Magnetic Resonance Imaging Agent

Characterization and cellular studies of molecular nanoparticle of iron (III)-tannic complexes; toward a low cost magnetic resonance imaging agent

2017 ◽  
Vol 12 (2) ◽  
pp. 021005 ◽  
Author(s):  
Saowalak Krungchanuchat ◽  
Titipun Thongtem ◽  
Somchai Thongtem ◽  
Chalermchai Pilapong
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Low Cost ◽  
Imaging Agent ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Agent
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