Cerebral Venous Thrombosis (CVT) is an uncommon cause of stroke and is generally present with headache. It is very difficult to diagnose it in initial stage due to its widely varying clinical features, risk factors, radiological findings and outcomes. Early diagnosis of CVT and its treatment can reduce the disease progress, its burden and risk of acute and long-term complications including mortality. A 23-year-old male patient was admitted from casualty department with complaints of severe generalised headache and photophobia since one week and four episodes of Generalised Tonic Clonic Seizures (GTCS) with post-ictal confusion and drowsiness since two days. All investigations were insignificant for the cause except that he was a sickle cell trait (AS pattern), that lead to CVT related headache and convulsion. He was treated with hydration in the form of intravenous fluids, warfarin, mannitol and syrup glycerol, Tab. Sodium bicarbonate and Tab. Hydroxyurea.