scholarly journals Seventy-Four–Month Follow-Up of Coronary Vulnerable Plaques by Serial Gray-Scale Intravascular Ultrasound

Circulation ◽  
2012 ◽  
Vol 126 (24) ◽  
pp. 2878-2879 ◽  
Author(s):  
Pascal Motreff ◽  
Gilles Rioufol ◽  
Gérard Finet
Keyword(s):  
Intravascular Ultrasound ◽  
Gray Scale ◽  
Vulnerable Plaques

scholarly journals Contrast-less stent placement for vertebral artery origin stenosis

2016 ◽  
Vol 23 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Shinzo Ota ◽  
Yoshinobu Sekihara ◽  
Takahiro Himeno ◽  
Yasue Tanaka ◽  
Tatsuya Ohtonari
Keyword(s):  
Renal Function ◽  
Contrast Medium ◽  
Vertebral Artery ◽  
Intravascular Ultrasound ◽  
Male Patient ◽  
Stent Placement

We performed stent placement under intravascular ultrasound (IVUS), without the use of contrast medium, in a male patient in his 70s who had vertebral artery origin stenosis and decreased renal function. Satisfactory dilatation was achieved without complications, and the patient remained asymptomatic at 2 years of follow-up. We now report the details of this procedure. Stent placement under IVUS guidance may be useful in patients in whom contrast medium is contraindicated.

scholarly journals Mechanical and structural characteristics of vulnerable plaques: analysis by coronary angioscopy and intravascular ultrasound

2001 ◽  
Vol 38 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Masamichi Takano ◽  
Kyoichi Mizuno ◽  
Kentaro Okamatsu ◽  
Shinya Yokoyama ◽  
Takayoshi Ohba ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Structural Characteristics ◽  
Vulnerable Plaques ◽  
Coronary Angioscopy

scholarly journals Possibilities of Multiparametric Ultrasound Study with Contrast Enhanced in the Diagnostics of Cistic Kidney Lesions

2021 ◽  
Vol 4 (3) ◽  
pp. 35-43
Author(s):  
R. A. Kadyrleev ◽  
S. S. Bagnenkо ◽  
E. A. Busko ◽  
E. V. Kostromina ◽  
L. N. Shevkunov ◽  
...  
Keyword(s):  
Color Doppler ◽  
Renal Cysts ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Cystic Kidney ◽  
Gray Scale ◽  
Ultrasound Study ◽  
Contrast Enhanced ◽  
Contrast Ultrasound

Purpose: To compare the capabilities and evaluate the effectiveness of gray-scale B-mode, Doppler mapping and contrast enhanced in the assessment of cystic renal lesions.Material and methods: Ultrasound examination (US) was performed in 61 patients with cystic kidney formations (category Bosniak ≥ II). Cysts of categories Bosniak ≥ III were histologically verified, rest (categories II–IIF) were under follow up. All patients underwent gray-scale ultrasound, color Doppler imaging and contrast enhanced (CEUS).Results: The efficiency of the B mode was: sensitivity 55.6 %; specificity 72.1 %; accuracy 62.3 %, in the CDI mode these indicators were 52.8; 80.1; 63.9 %, respectively. Contrast ultrasound significantly increased the capabilities of the method, and also made it possible to evaluate cystic formations according to the Bosniak criteria with indicators of the effectiveness of the method up to 100.0; 92.0; 96.7 %, respectively.Conclusions: CEUS demonstrated high informative value in the assessment of renal cystic formations in comparison with native ultrasound and Doppler modes, and therefore the technique should be considered as promising for inclusion in the algorithm of examination of complex renal cysts. 

P869Predictive value of the endothelial shear stress distribution in three-dimensional quantitative coronary angiography models in detecting vulnerable plaques

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Zanchin ◽  
C Bourantas ◽  
R Torii ◽  
P W S Serruys ◽  
A Karagiannis ◽  
...  
Keyword(s):  
Shear Stress ◽  
High Risk ◽  
Coronary Angiography ◽  
Intravascular Ultrasound ◽  
Three Dimensional ◽  
Quantitative Coronary Angiography ◽  
Low Risk ◽  
Plaque Burden ◽  
Vulnerable Plaques ◽  
Endothelial Shear Stress

Abstract Background Low Endothelial shear stress (ESS) is a well-known instigator of coronary atherosclerosis. Prospective intravascular ultrasound (IVUS)-based imaging studies with computational fluid dynamic analysis revealed its predictive merit in-vivo. However, whether coronary modelling derived from quantitative coronary angiography (QCA) is equally effective in detecting high-risk plaques remains to be established. Purpose To examine the value of endothelial shear stress (ESS) estimated in three-dimensional (3D) QCA models in detecting plaques that are likely to progress and cause events. Method We analysed the baseline intravascular ultrasound virtual histology (IVUS-VH) and angiographic data from 28 non-culprit lesions with a vulnerable phenotype (i.e., fibroatheroma or thin cap fibroatheroma) that caused major adverse cardiac events or required revascularization (nc-MACE-R) at 5-year follow-up and from a control group of 119 vulnerable plaques that remained quiescent. The segments studied by IVUS-VH at baseline were reconstructed using 3D-QCA software and in the obtained geometries blood flow simulation was performed and we estimated the resting Pd/Pa across the vulnerable plaque and the mean ESS values in 3mm sub-segments. A propensity score was built by the baseline plaque characteristics and the hemodynamic indices and its efficacy in detecting nc-MACE-R lesions was examined. Results Nc-MACE-R lesions were longer (32.5mm [18.0, 41.6], vs. 19.6mm [12.7, 31.3], p=0.03), had smaller minimum lumen area (MLA) (3.65mm2 [3.26, 4.36] vs. 5.03mm2 [3.98, 6.66], p<0.01), increased plaque burden (PB) (69.4% [63.5, 72.0] vs. 60.8% [53.7, 66.5], p<0.01), were exposed to higher ESS (9.40Pa [6.3, 12.5] vs. 4.1Pa [3.0, 6.9], p<0.01), and exhibited a lower resting Pd/Pa (0.97 [0.95, 0.98] vs. 0.98 [0.97, 0.99], p<0.01]. In multivariable analysis the only independent predictor of nc-MACE-R was the maximum 3mm ESS value (hazard ratio: 1.08 [1.02, 1.16], P=0.016). Lesions exposed to high ESS (>4.95Pa) with a high-risk anatomy (MLA<4mm2and PB>70%) had a higher nc-MACE-R rate (53.8%) than those with a low-risk anatomy exposed to high ESS (31.6%) or those exposed to low ESS that had high (20.0%) or low-risk anatomy (7.1%, P<0.001). Conclusion In the present study, 3D-QCA-derived local hemodynamic variables provided useful prognostic information and in combination with lesion anatomy enabled more accurate identification of nc-MACE-R lesions. Further research in a larger number of patients is need to confirm these findings before the conduction of large scale prospective studies that will combine intravascular imaging and 3D-QCA modelling to more accurately detect vulnerable plaques.

Relationship between arterial remodelling and serial changes in coronary atherosclerosis by intravascular ultrasound: an analysis of the IBIS-4 study

2020 ◽  
Author(s):  
Konstantinos C Koskinas ◽  
Rafaela Maldonado ◽  
Hector M Garcia-Garcia ◽  
Kyohei Yamaji ◽  
Masanori Taniwaki ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Coronary Atherosclerosis ◽  
Reference Site ◽  
Statin Treatment ◽  
Vascular Changes ◽  
Novel Approach ◽  
Local Reference ◽  
Atheroma Volume ◽  
Significant Regression

Abstract Aims Arterial remodelling is an important determinant of coronary atherosclerosis. Assessment of the remodelling index, comparing a lesion to a local reference site, is a suboptimal correlate of serial vascular changes. We assessed a novel approach which, unlike the local-reference approach, uses the entire artery’s global remodelling as reference. Methods and results Serial (baseline and 13 months) intravascular ultrasound was performed in 146 non-infarct-related arteries of 82 patients treated with high-intensity statin. Arteries were divided into 3-mm segments (n = 1479), and focal remodelling was characterized in individual segments at both timepoints applying the global arterial reference approach. First, we compared preceding vascular changes in relation to follow-up remodelling. Second, we examined whether baseline remodelling predicts subsequent plaque progression/regression. At follow-up, segments with constrictive vs. compensatory or expansive remodelling had greater preceding reduction of vessel area (−0.67 vs. −0.38 vs. −0.002 mm2; P &lt; 0.001) and lumen area (−0.82 vs. −0.09 vs. 0.40 mm2; P &lt; 0.001). Overall, we found significant regression in percent atheroma volume (PAV) [−0.80% (−1.41 to −0.19)]. Segments with constrictive remodelling at baseline had greater subsequent PAV regression vs. modest regression in the compensatory, and PAV progression in the expansive remodelling group (−6.14% vs. −0.71% vs. 2.26%; P &lt; 0.001). Lesion-level analyses (n = 118) showed no differences when remodelling was defined by the local reference approach at baseline or follow-up. Conclusion Remodelling assessment using a global arterial reference approach, but not the commonly used, local reference site approach, correlated reasonably well with serial changes in arterial dimensions and identified arterial segments with subsequent PAV progression despite intensive statin treatment and overall atheroma regression.

scholarly journals Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Rui Lv ◽  
Akiko Maehara ◽  
Mitsuaki Matsumura ◽  
Liang Wang ◽  
Qingyu Wang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intravascular Ultrasound ◽  
Coronary Plaque ◽  
Mean Value ◽  
Optical Coherence ◽  
Plaque Vulnerability ◽  
Fibrous Cap ◽  
Vulnerable Plaques ◽  
The Mean ◽  
Thickness Measurements

Abstract Background Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research community. Intravascular ultrasound (IVUS) is commonly used in clinical practice for diagnosis and treatment decisions. However, due to IVUS limited resolution (about 150–200 µm), it is not sufficient to detect vulnerable plaques with a threshold cap thickness of 65 µm. Optical Coherence Tomography (OCT) has a resolution of 15–20 µm and can measure fibrous cap thickness more accurately. The aim of this study was to use OCT as the benchmark to obtain patient-specific coronary plaque cap thickness and evaluate the differences between OCT and IVUS fibrous cap quantifications. A cap index with integer values 0–4 was also introduced as a quantitative measure of plaque vulnerability to study plaque vulnerability. Methods Data from 10 patients (mean age: 70.4; m: 6; f: 4) with coronary heart disease who underwent IVUS, OCT, and angiography were collected at Cardiovascular Research Foundation (CRF) using approved protocol with informed consent obtained. 348 slices with lipid core and fibrous caps were selected for study. Convolutional Neural Network (CNN)-based and expert-based data segmentation were performed using established methods previously published. Cap thickness data were extracted to quantify differences between IVUS and OCT measurements. Results For the 348 slices analyzed, the mean value difference between OCT and IVUS cap thickness measurements was 1.83% (p = 0.031). However, mean value of point-to-point differences was 35.76%. Comparing minimum cap thickness for each plaque, the mean value of the 20 plaque IVUS-OCT differences was 44.46%, ranging from 2.36% to 91.15%. For cap index values assigned to the 348 slices, the disagreement between OCT and IVUS assignments was 25%. However, for the OCT cap index = 2 and 3 groups, the disagreement rates were 91% and 80%, respectively. Furthermore, the observation of cap index changes from baseline to follow-up indicated that IVUS results differed from OCT by 80%. Conclusions These preliminary results demonstrated that there were significant differences between IVUS and OCT plaque cap thickness measurements. Large-scale patient studies are needed to confirm our findings.

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