Abstract TP345: Improving Door to Drug Times for Ischemic Stroke Patients Using a Team Approach

Background and Purpose: Decreasing door to drug times for ischemic stroke patients has been proven to optimize preservation of brain tissue, resulting in better functional outcomes. In prior years, the stroke team focus was to meet or exceed the 50% goal for the Joint Commission measure; patients arriving within 2 hours of last known well receive alteplase within 180 minutes. In the fall of 2011, the Neuroscience Medical Director challenged the team to meet target stroke goals and achieve the gold standard of excellence. Methods: Guided by the Plan Do Study Act model and principles of shared governance, the team refocused efforts to enhance stakeholder collaboration, educate, and provide monthly evaluation of door to door times. Code Stroke pathways were revised to improve efficiency, and inclusion / exclusion criteria were revised. The team is presented with state and national benchmark best practice data on an ongoing basis. Individual alteplase case feedback sheets are sent to all involved providers and departments, who are encouraged to provide input into the process. All alteplase cases are reviewed during team meetings, and outcomes are shared. Role modeling, physician engagement, positive feedback to team members and celebration of successes instill team motivation and confidence. In June, the program hosted an inaugural Stroke Symposium, where national speakers shared the ‘state of the science’, validating the rationale for improving processes for acute stroke care. Results: In the first 6 months of 2012, the median door to drug time was reduced by 48% to 55 minutes from 104 minutes in 2011. In the same time period, 10 of 15 patients had alteplase administered in < 60 minutes, versus 2 of 25 in 2011. Conclusions: Significant improvements in stroke care can be gained by establishing a cohesive team with a shared goal of excellence. Strong leadership, the ability of staff on all levels to be partners in decision making, information sharing, education and recognition are keys to success. Future challenges include ensuring the processes are sustainable, and maintaining team motivation to continue to find opportunities to reduce door to drug times.

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Abstract T P188: Equivalency in Intravenous Thrombolytic Treatment Rates Between Primary Stroke Centers and Non-Primary Stroke Centers Through the Use of Telestroke

Stroke ◽

10.1161/str.45.suppl_1.tp188 ◽

2014 ◽

Vol 45 (suppl_1) ◽

Author(s):

Archit Bhatt ◽

Elizabeth Barban ◽

Leslie Corless ◽

Tamela Stuchiner ◽

Amit Kansara

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Symptom Onset ◽

Stroke Care ◽

Bivariate Analysis ◽

Stroke Patients ◽

Acute Stroke Care ◽

Stroke Registry ◽

Patient Arrival ◽

History Of

Background: Research has shown that subjects evaluated at (Primary Stroke Centers) PSCs are more likely to receive rt–PA than those evaluated at non–PSCs. It is unknown if telestroke evaluation affects rt-PA rates at non-PSCs. We hypothesized that with a robust telestroke system rt-TPA rates among PSCs and non-PSCs are not significantly different. Methods and Results: Data were obtained from the Providence Stroke Registry from January 2010 to December 2012. We identified ischemic stroke patients (n=3307) who received care in Oregon and Southwest Washington, which include 2 PSCs and 14 non-PSCs. Intravenous rt–PA was administered to 7.3% (n=242) of ischemic patients overall, 8.4% (n=79) at non–PSCs and 6.9% (n=163) at PSCs (p=.135). Stroke neurologists evaluated 5.2 % (n=172) of all ischemic stroke patients (n=3307) were evaluated via telestroke robot. Our analysis included AIS (Acute Ischemic Stroke) patients, those presenting within 4.5 hours of symptom onset. We identified 1070 AIS discharges from 16 hospitals of which 77.9 % (n=833) were at PSCs and 22.1 % (n=237) non-PSCs. For acute ischemic stroke patients (AIS) patients, those presenting within 4.5 hours of symptom onset, 22.1% (n=237) received rt-PA; 21.5% (n=74) presented at non–PSCs and 23.7% (n=163) presented at PSCs. Among AIS, bivariate analysis showed significant differences in treatment rates by race, age, NIHSS at admit, previous stroke or TIA, PVD, use of robot, smoking and time from patient arrival to CT completed. Using multiple logistic regression adjusting for these variables, treatment was significantly related to admit NIHSS (AOR=1.67, p<.001), history of stroke (AOR=.323, p<.001), TIA (AOR=.303, p=.01) and PVD (AOR=.176, p=.02), time to CT (.971, p<.001), and use of robot (7.76, p<.001). PSC designation was not significantly related to treatment (p=.06). Conclusions: Through the use of a robust telestroke system, there are no significant differences in the TPA treatment rates between non-PSC and PSC facilities. Telestroke systems can ensure stroke patients access to acute stroke care at non-PSC hospitals.

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Why Stroke Patients Don’t Receive T-PA? An Analysis of Patient Eligibility: Implications for Improving Clinical Impact by Increasing Future Treatment Numbers

Stroke ◽

10.1161/str.32.suppl_1.372-d ◽

2001 ◽

Vol 32 (suppl_1) ◽

pp. 372-372

Author(s):

Philip A Barber ◽

Jinijin Zhang ◽

Andrew M Demchuk ◽

Michael D Hill ◽

Andrea Cole-Haskayne ◽

...

Keyword(s):

Emergency Department ◽

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Stroke Care ◽

Stroke Patients ◽

Acute Stroke Care ◽

Stroke Registry ◽

Specific Protocol ◽

Stroke Type ◽

Ischemic Attack

P183 Background T-PA is an effective treatment of acute ischemic stroke within 3 hours. However, the success of t-PA on reducing disability is dependent on it being accessible to more patients. We identified the reasons why patients with ischemic stroke did not receive intravenous t-PA and assessed the community impact of the therapy in a large North American city. Methods Consecutive patients with acute ischemic stroke were identified in a prospective stroke registry at a teaching hospital between October 1996 and December 1999. Additional patients with ischemic stroke admitted to one of three other hospitals during the study period were identified. The Oxford Community Stroke Program Classification was used to record stroke type. Results Of 2165 stroke patients presenting to the emergency department 1179 (54.5%) were diagnosed with ischemic stroke, 31.7% with intracranial hemorrhage, and 13.8 % with transient ischemic attack. 84/339 (29%) patients were admitted within 3 hours of stroke received intravenous t-PA. The major reasons for exclusion for stroke patients presenting within 3 hours were mild stroke (20%), clinical improvement (18.6%), and specific protocol exclusions (11.5%). Delay in presentation to emergency department excluded 840/1179 (71%). 1817 ischemic stroke patients were admitted to Calgary hospitals during the study period of which 4.6% received intravenous t-PA. Generalization of the Calgary experience to other Canadian communities suggests the benefit from t-PA for ischemic stroke may be substantial with an additional 460 independent survivors per annum. Conclusion The effectiveness of t-PA can be improved by understanding why patients are excluded from its use. The eligibility of patients for t-PA must increase by promoting health education programs and by developing organized acute stroke care infrastructure within the community.

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Abstract 267: Improving Inpatient Stroke Care by Implementing Stroke Units Across Health Systems Using an Improvement Collaborative Approach

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.7.suppl_1.267 ◽

2014 ◽

Vol 7 (suppl_1) ◽

Author(s):

Noreen Kamal ◽

Pamela Aikman ◽

Philip Teal ◽

Michael Suddes ◽

Todd Collier ◽

...

Keyword(s):

Quality Improvement ◽

Stroke Unit ◽

Best Practice ◽

Interdisciplinary Team ◽

Stroke Care ◽

Quality Improvement Initiative ◽

Stroke Patients ◽

Acute Stroke Care ◽

Learning Session ◽

Stroke Units

Background: Stroke units, defined as a geographic location where stroke patients are cared for by an interdisciplinary team, hold the strongest evidence in reduced mortality and disability for stroke patients. However, according to the 2011 Canadian Stroke Network’s National Stroke Audit, only 23% of stroke patients in Canada were admitted to a Stroke Unit with the Canadian province of British Columbia (BC) lagging at only 4%. The objective of this quality improvement initiative was to increase the number of stroke units and to improve existing stroke units; additionally, we aimed to improve adherence to best practice acute stroke care. Methods: Using the Institute for Healthcare Improvement’s Breakthrough Series Collaborative methodology, a stroke unit Improvement Collaborative was run from January 2013 to December 2013 by Stroke Services BC, a program of the Provincial Health Services Authority in BC. Faculty members were recruited from BC and the Calgary Stroke Program in the province of Alberta. The collaborative had 4 Learning Sessions, a closing workshop, and bi-weekly webinars. Teams followed a structured 7-step framework: understanding current volumes; securing space; establishing the team; ensuring clinical best practice; creating processes for team communication; ensuring patient engagement; and establishing quality improvement mechanisms. Pre and post self-reports of care were collected through electronic polling at Learning Session 2 in February 2013 (pre, n=78) and at the Closing Celebration in December 2013 (post, n=66) using a 4-point Likert scale. There were 20 questions based on best practice. Results: Eleven teams enrolled representing 17 hospitals in BC and a hospital in Saskatoon in the province of Saskatchewan. Teams were either working at the hospital or health region level. There were a total of 75 new stroke beds created in BC, and 12 beds recommended for Saskatoon. Furthermore, the results from the e-voting on best practice showed statistically significant improvement in the following areas: admission to a stroke unit (p=0.005); assessment by an interdisciplinary team within 48 hours of admission (p=0.002); use of standardized valid tools (p=0.002); swallowing screen within 24 hours (p<0.001); core interprofessional team on the stroke unit (p<0.001); care to prevent secondary complication (p<0.001); management of serum lipid levels (p=0.017); patient education (p<0.001); and team education (p=0.02). Conclusions: This inter-provincial Quality Improvement Collaborative was successful in implementing and improving stroke units, and in improving best practice care of inpatient stroke patients. Critical success factors include the engagement of faculty from high-performing centers even if they exist outside the jurisdiction where improvement is sought, and the use of the 7-step framework for implementing stroke units.

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Abstract P119: Factors Influencing Door to Needle Administration for Acute Stroke Patients in the Emergency Department

Stroke ◽

10.1161/str.52.suppl_1.p119 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Nicolle W Davis ◽

Meghan Bailey ◽

Natalie Buchwald ◽

Amreen Farooqui ◽

Anna Khanna

Keyword(s):

Emergency Department ◽

Ischemic Stroke ◽

Acute Stroke ◽

Acute Ischemic Stroke ◽

Patient Outcomes ◽

Time Of Day ◽

Stroke Patients ◽

Acute Stroke Care ◽

The Impact ◽

Iv Tpa

Background/Objective: There is growing importance on discovering factors that delay time to intervention for acute ischemic stroke (AIS) patients, as rapid intervention remains essential for better patient outcomes. The management of these patients involves a multidisciplinary effort and quality improvement initiatives to safely increase treatment with intravenous thrombolytic (IV tPa). The objective of this pilot is to evaluate factors of acute stroke care in the emergency department (ED) and the impact they have on IV tPa administration. Methods: A sample of 89 acute ischemic stroke patients that received IV tPa from a single academic medical institution was selected for retrospective analysis. System characteristics (presence of a stroke nurse and time of day) and patient characteristics (mode of arrival and National Institutes of Health Stroke Scale score (NIHSS) on arrival) were analyzed using descriptive statistics and multiple regression to address the study question. Results: The mean door to needle time is 53.74 minutes ( + 38.06) with 74.2% of patients arriving to the ED via emergency medical services (EMS) and 25.8% having a stroke nurse present during IV tPa administration. Mode of arrival ( p = .001) and having a stroke nurse present ( p = .022) are significant predictors of door to needle time in the emergency department (ED). Conclusion: While many factors can influence door to needle times in the ED, we did not find NIHSS on arrival or time of day to be significant factors. Patients arriving to the ED by personal vehicle will have a significant delay in IV tPa administration, therefore emphasizing the importance of using EMS. Perhaps more importantly, collaborative efforts including the addition of a specialized stroke nurse significantly decreased time to IV tPa administration for AIS patients. With this dedicated role, accelerated triage and more effective management of AIS patients is accomplished, leading to decreased intervention times and potentially improving patient outcomes.

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Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018

International Journal of Stroke ◽

10.1177/1747493018786616 ◽

2018 ◽

Vol 13 (9) ◽

pp. 949-984 ◽

Cited By ~ 73

Author(s):

JM Boulanger ◽

MP Lindsay ◽

G Gubitz ◽

EE Smith ◽

G Stotts ◽

...

Keyword(s):

Emergency Department ◽

Ischemic Stroke ◽

Acute Stroke ◽

Transient Ischemic Attack ◽

Best Practice ◽

Stroke Care ◽

Stroke Management ◽

Practice Recommendations ◽

Prehospital Emergency ◽

Ischemic Attack

The 2018 update of the Canadian Stroke Best Practice Recommendations for Acute Stroke Management, 6th edition, is a comprehensive summary of current evidence-based recommendations, appropriate for use by healthcare providers and system planners caring for persons with very recent symptoms of acute stroke or transient ischemic attack. The recommendations are intended for use by a interdisciplinary team of clinicians across a wide range of settings and highlight key elements involved in prehospital and Emergency Department care, acute treatments for ischemic stroke, and acute inpatient care. The most notable changes included in this 6th edition are the renaming of the module and its integration of the formerly separate modules on prehospital and emergency care and acute inpatient stroke care. The new module, Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care is now a single, comprehensive module addressing the most important aspects of acute stroke care delivery. Other notable changes include the removal of two sections related to the emergency management of intracerebral hemorrhage and subarachnoid hemorrhage. These topics are covered in a new, dedicated module, to be released later this year. The most significant recommendation updates are for neuroimaging; the extension of the time window for endovascular thrombectomy treatment out to 24 h; considerations for treating a highly selected group of people with stroke of unknown time of onset; and recommendations for dual antiplatelet therapy for a limited duration after acute minor ischemic stroke and transient ischemic attack. This module also emphasizes the need for increased public and healthcare provider’s recognition of the signs of stroke and immediate actions to take; the important expanding role of paramedics and all emergency medical services personnel; arriving at a stroke-enabled Emergency Department without delay; and launching local healthcare institution code stroke protocols. Revisions have also been made to the recommendations for the triage and assessment of risk of recurrent stroke after transient ischemic attack/minor stroke and suggested urgency levels for investigations and initiation of management strategies. The goal of this updated guideline is to optimize stroke care across Canada, by reducing practice variations and reducing the gap between current knowledge and clinical practice.

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Abstract P184: Effect of Acute Stroke Care Hospital Networks in Korea

Stroke ◽

10.1161/str.52.suppl_1.p184 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Jihoon Kang ◽

Seong Eun Kim ◽

Hyunjoo Song ◽

Hee-joon Bae

Keyword(s):

Network Analysis ◽

Acute Stroke ◽

Stroke Care ◽

The Other ◽

Care Hospital ◽

Initial Visit ◽

Analysis Method ◽

Stroke Patients ◽

Acute Stroke Care ◽

Hospital Networks

Purpose: Stroke patients generally transport stroke patients either to nearest stroke hospital with secondary transfers or to hub hospitals in selective cases. This study aimed to determine the stroke community of close networks and to evaluate their role for the access the endovascular treatment (EVT). Methods: Using the nationwide acute stroke hospital (ASH) surveillance data assessed the major quality indicators of all stroke patients of South Korea, triage information both initial visit and secondary interhospital transfers were extracted according to the hospitals. Based on them, stroke community with dense linkages were partitioned using the network-based Louvain algorithm. The hierarchical model estimated the function of stroke community for the EVT. Results: For 6-month surveying period, 19113 subjects admitted to the 246 ASHs. Of them, 1831 (9.6%) were transferred from 763 adjacent facilities not ASH, while 1283 (6.7%) from the other ASHs. The algorithm determined the 113 stroke communities where composed median 7 hospitals (2 ASHs and 5 adjacent facilities) and treated about 30 subjects per month. Most of communities formed the spindle shape with higher centralization index and located within 150 Km (Figure). Stroke communities significantly affected 11% of EVT after adjustments. Conclusions: Network analysis method effectively contoured the high centralizing stroke communities and helped the functions on the EVT accessibility.

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Abstract WMP68: Smartphone Support System for Mobile Imaging Display and Management of Acute Stroke

Stroke ◽

10.1161/str.47.suppl_1.wmp68 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Kristina Shkirkova ◽

Eftitan Y Akam ◽

Josephine F Huang ◽

Sunil A Sheth ◽

May Nour ◽

...

Keyword(s):

Acute Stroke ◽

Stroke Care ◽

Final Diagnosis ◽

Integrated System ◽

Ease Of Use ◽

Imaging Data ◽

Acute Stroke Care ◽

Team Members ◽

Information Platform ◽

Stroke Team

Introduction: Rapid dissemination and coordination of clinical and imaging data among multidisciplinary team members is essential for optimal acute stroke care. Standard desktop EMRs are ill-suited for this purpose, but mobile smartphone and tablet applications are highly promising platforms for accelerated, data-driven patient diagnosis and treatment. This study tested an advanced mobile integrated system for distribution of patient clinical and imaging information. Methods: We tested the iStroke/Synapse ERm system (Figure) for smartphone and tablet display and integration of clinical data, CT, MR, and catheter angiographic imaging, and real-time stroke team communications, in consecutive acute neurovascular patients at a Comprehensive Stroke Center. Results: From 5/2014 to 10/2014, the Synapse ERm application was installed and used by 33 stroke team members, in 84 Code Stroke ED patients. Patient age was 69.1 (±17.5), with 40.5% female. Final diagnosis was: ischemic stroke 66%, TIA 7%, ICH 6%, and CV mimic 21%. Each patient record was viewed on average 13 times by at least 3 team members. The most used feature was CT, MR and cath angio image display, viewed on average 4 times per patient by at least 2 users. In-app tweet team communications were sent by average 2 users per case and viewed by average 6 team members. Use of the system was associated with treatment times that exceeded national guideline targets for thrombolysis and endovascular thrombectomy, including door-to-needle 50 min (IQR 24-60) and door-to-groin 92 min (IQR 65-128). In user surveys, the mobile information platform was judged easy to employ in 91% of uses and of added help in stroke management in a substantial majority of cases. Conclusion: The Synapse ERm system, a smartphone/tablet platform for stroke team communication and distribution and integration of clinical and imaging data, showed high ease of use, substantial added management value, and association with rapid processes of care.

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Abstract TMP77: Race and Sex Differences in tPA Utilization Among Older Ischemic Stroke Patients

Stroke ◽

10.1161/str.48.suppl_1.tmp77 ◽

2017 ◽

Vol 48 (suppl_1) ◽

Author(s):

Michael Lyerly ◽

Farhaan Vahidy ◽

John Donnelly ◽

Katrina Booth ◽

Karen C Albright

Keyword(s):

Ischemic Stroke ◽

Nationwide Inpatient Sample ◽

Stroke Care ◽

Acute Stroke Care ◽

Older Americans ◽

Lower Odds ◽

Medical Comorbidities ◽

Procedure Code ◽

Receive Treatment ◽

Iv Tpa

Introduction: The risk of ischemic stroke doubles for each decade beyond the age of 55. While disparities, particularly racial disparities, have been described for many aspects of acute stroke care, these disparities have not been well characterized among older adults. The purpose of this analysis was to evaluate potential differences in IV-tPA utilization among acute ischemic stroke (AIS) patients aged ≥65 years. Methods: We used the Nationwide Inpatient Sample (NIS) to examine primary AIS diagnosis discharges (ICD-9 codes 433.x1, 434.x1 and 436) from US hospitals over 2006-2011, among those aged ≥ 65 years. Utilization of IV-tPA was identified using procedure code 99.10. Multivariate logistic regression was conducted to determine age and race associations with IV tPA utilization. Results: Over the 6 year study period, we identified 1.5 million ischemic stroke discharges, with 3.9% receiving IV-tPA. Compared to discharges who did not receive treatment, those receiving IV-tPA were less likely to be female and black. The odds of women receiving IV-tPA were 10% lower than men. After adjusting for demographics, insurance, and medical comorbidities, the odds of women receiving IV-tPA were still 5% lower (Table). When compared to non-black discharges, older blacks were at 25% lower odds of receiving IV-tPA. After adjusting for demographics, insurance and medical comorbidities, older blacks were at 22% lower odds of receiving IV-tPA (Table). Conclusions: Among older Americans, women and blacks have lower odds of being treated with IV-tPA, even after adjusting for age, insurance and comorbidities. A greater understanding of the reasons for these unexplained differences in the fastest growing proportion of our population is needed.

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Abstract T P260: Confirmation: The Target Stroke Best Practice Strategies Work

Stroke ◽

10.1161/str.46.suppl_1.tp260 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Nojan Valadi ◽

Alexis Thomas

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Process Improvement ◽

Best Practice ◽

Stroke Patients ◽

High Performers ◽

Process Implementation ◽

Honor Roll ◽

Stroke Team ◽

Stroke Center

Background: A recent national push for optimizing stroke center performance led by the efforts of AHA/ASA to recognize high performers with the Target Stroke Honor Roll recognition have focused on achieving expedited treatment for stroke with door-to-needle (DTN) time of ≤60 minutes.Our organization recognized the need to optimize our performance and set an initial goal of achieving DTN time of ≤60 minutes in greater than 50% of our patients. The Target Stroke Initiative by the AHA/ASA identified 10 key strategies for best practice associated with reducing DTN times. Our organization adopted and implemented all of these strategies over a 30-day period. Methods: The Target Stroke best practice strategies were implemented over a 30-day period, and the Stroke Team worked collaboratively to identify other weaknesses needing to be addressed. DTN times ≤60 minutes from the 12 months prior to process improvement implementation were compared with the first 2 months post implementation. Results: There were 345 ischemic stroke patients treated at our facility during the 12 month period prior to the process implementation, with a total of 14 patients (1.12 per month) treated with tPA. The percentage of patients treated with tPA was 4%, and the percentage of patients treated with DTN ≤60 minutes was 0%. Over the two months following process implementation, 68 ischemic stroke patients were treated at our facility, with 11 patients treated with tPA (5.5 per month). The percentage of stroke patients treated with tPA was 16%, with 70% of patients treated with DTN ≤60 minutes. Conclusion: This study serves as confirmation that collaboration and implementation of the 10 key strategies for best practice as outlined by the Target Stroke Initiative, coupled with changes to identified areas of weakness, can improve and expedite the care of patients with acute ischemic stroke. This can substantially improve DTN times, as well as the overall number and percentage of patients that receive thrombolysis with a hopeful impact on their outcome as well as Target Stroke Honor Roll recognition for the facility. In conclusion, we recommend implementation of these best practice strategies to other facilities.

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Abstract 20: Acute Stroke Care and Thrombolysis at Critical Access Hospitals in Illinois

Stroke ◽

10.1161/str.44.suppl_1.a20 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Shyam Prabhakaran ◽

Robin Hamann ◽

Kathleen O’Neill ◽

Michelle Gardner ◽

Peggy Jones

Keyword(s):

Quality Improvement ◽

Acute Stroke ◽

Stroke Care ◽

The United States ◽

Critical Access Hospitals ◽

Stroke Patients ◽

Acute Stroke Care ◽

Improvement Program ◽

Discharge Disposition ◽

Intravenous Tissue Plasminogen Activator

Background: Critical access hospitals (CAH) are the first point of stroke care in many rural regions of the United States (US). The Illinois Critical Access Hospital Network (ICAHN), a network of 51 CAH in Illinois, began a quality improvement program to address acute stroke care in 2009. We evaluated the performance on several metrics in acute stroke care at CAH between 2009 and 2011. Methods: Currently, 28 of 51 CAHs in Illinois currently participate in the American Heart Association’s Get With The Guidelines - Stroke (GWTG-S) registry for quality improvement. The GWTG-S registry captured elements including demographics, diagnosis, times of arrival, imaging completion, and intravenous tissue plasminogen activator (IV tPA) administration, and final discharge disposition. We analyzed the change in percent of stroke patients receiving tPA, door-to-needle (DTN) time, and proportion of total stroke patients admitted versus transferred to another facility over the 3 years. Fisher’s exact and Mann-Whitney tests were used as appropriate. Results: In the baseline assessment (2009), there were 111 strokes from 8 sites which grew to 12 sites and 305 strokes in year 1 (2010) and 14 sites and 328 strokes in year 3 (2011). The rate of tPA use for ischemic stroke was 2.2% in 2009, 4.0% in 2010, and 6.2% in 2011 (P=0.20). EMS arrival (41.1%), EMS pre-notification (82.6%), door-to-CT times (median 35 minutes; 34.6% < 25 minutes), and DTN times (average 93 minutes; 13.3% DTN time < 60 minutes) were not different over time. The rate of transfer from CAH to another hospital (51.3%) was constant. Every patient that received tPA except 1 (96.9%) was transferred (drip-ship) for post-tPA care. Conclusions: Improving acute stroke care at CAHs is feasible and represents a significant opportunity to increase tPA utilization in rural areas. As stroke systems develop, it is vital that CAHs be included in quality improvement efforts. The ICAHN stroke collaborative provided the opportunity to coordinate resources, share best practices, participate in targeted educational programming, and utilize data for performance improvement through the funded GWTG-S registry.

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