By examining the science behind leadership, management practices and how they relate to social cognitive neuroscience, we can understand how to target the most effective conditions for preventing workplace burnout and workplace depression. This process begins with the ability of managers to recognise and react responsively to create a culture of trust within the organisation, and identify and promote prosocial behaviours to prevent feelings of disengagement and displacement. This review discusses how one’s ability to inspire employees is particularly important, because followers with low self-concepts are drawn to a highly personalised vision. Through the promotion of the brain chemical, oxytocin, the material presents eight building blocks to promote a culture of trust, while mitigating the factors associated with workplace burnout and workplace depression.