Involvement of Intracellular Sphingosine-1-Phosphate in Lung Endothelial Cell Motility: Role of Sphingosine Kinase 1, Sphingosine-1-Phosphate Lyase and Serine Palmitoyl Transferase.

2009 ◽  
Author(s):  
I Gorshkova ◽  
E Berdyshev ◽  
P Usatyuk ◽  
S Kalari ◽  
Y Zhao ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Motility ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Sphingosine 1 Phosphate

scholarly journals Role of sphingosine kinase 1 and sphingosine‐1‐phosphate in CD40 signaling and IgE class switching

2014 ◽  
Vol 28 (10) ◽  
pp. 4347-4358 ◽  
Author(s):  
Eugene Y. Kim ◽  
Jamie L. Sturgill ◽  
Nitai C. Hait ◽  
Dorit Avni ◽  
Evelyn C. Valencia ◽  
...  
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 1 ◽  
Class Switching ◽  
Sphingosine 1 Phosphate

scholarly journals The Functional Role of Sphingosine Kinase 2

2021 ◽  
Vol 8 ◽  
Author(s):  
Rocio Diaz Escarcega ◽  
Louise D. McCullough ◽  
Andrey S. Tsvetkov
Keyword(s):  
Sphingosine Kinase ◽  
Telomere Maintenance ◽  
Sphingosine Kinase 1 ◽  
Lipid Molecule ◽  
Nuclear Signaling ◽  
Sphingosine Kinase 2 ◽  
Sphingosine 1 Phosphate ◽  
Associated Conditions ◽  
Health And Disease

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial respiration, among many other processes. SPHK2 is under investigation as a target for treating many age-associated conditions, such as cancer, stroke, and neurodegeneration. In this review, we will focus on the role of SPHK2 in health and disease.

scholarly journals The Role of Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in the Myogenic Tone of Posterior Cerebral Arteries

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e35177 ◽  
Author(s):  
Mihwa Lim ◽  
Soo-Kyoung Choi ◽  
Young-Eun Cho ◽  
Soo-In Yeon ◽  
Eok-Cheon Kim ◽  
...  
Keyword(s):  
Cerebral Arteries ◽  
Sphingosine Kinase ◽  
Myogenic Tone ◽  
Sphingosine Kinase 1 ◽  
Sphingosine 1 Phosphate

scholarly journals Sfingolipidi bioattivi e loro ruolo nell'azione biologica di fattori di crescita e citochine

2013 ◽  
Author(s):  
Caterina Bernacchioni
Keyword(s):  
Growth Factor ◽  
Sphingosine Kinase ◽  
Biological Action ◽  
Signalling Pathways ◽  
Sphingosine Kinase 1 ◽  
Sphingosine 1 Phosphate ◽  
Ceramide 1 ◽  
Muscular Damage ◽  
Fattori Di Crescita

This book gives an analysis of the role of the bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide 1-phosphate (C1P) in the skeletal muscle. The enzyme that produces S1P, sphingosine kinase 1 (SK1) has proved crucial in the biological action of growth factors and cytokines involved in the inflammatory process that follows muscular damage. Indeed, in myoblasts the cytokine TGFβ exercises its fibrotic action through induction of the SK1/S1P axis. Furthermore, the PDGF growth factor, positive regulator of proliferation and motility, activates the enzyme SK1 and the transactivation of S1P1 inhibits the proliferation and induces the migration induced by the growth factor. Finally, the mitogenic role of C1P in myoblasts has been identified, characterizing the signalling pathways involved.

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