Can We Identify Asthma Patients Who Can Safely Reduce Their Inhaled Corticosteroid Medication Without Suffering From A Loss Of Control?

2012 ◽  
Author(s):  
Emma E. Wilson ◽  
Bev Hargadon ◽  
Maria Shelley ◽  
Glenn Hearson ◽  
Rebecca Simms ◽  
...  
Keyword(s):  
Loss Of Control ◽  
Inhaled Corticosteroid ◽  
Asthma Patients

Omalizumab versus Mepolizumab as add-on therapy in asthma patients not well controlled on at least an inhaled corticosteroid: A network meta-analysis

2017 ◽  
Vol 55 (1) ◽  
pp. 89-100 ◽  
Author(s):  
Zahi Nachef ◽  
Amita Krishnan ◽  
Terry Mashtare ◽  
Tingting Zhuang ◽  
M. Jeffery Mador
Keyword(s):  
Meta Analysis ◽  
Inhaled Corticosteroid ◽  
Asthma Patients

scholarly journals 2221. Chlamydia pneumoniae (Cpn) Induces IFN-γ Responses in Peripheral Blood Mononuclear Cells (PBMC) from Pediatric and Adult Asthma Patients: Effects of Age and Inhaled Corticosteroid Use

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S758-S758
Author(s):  
Aviva Szigeti ◽  
Margaret Hammerschlag ◽  
Diana Weaver ◽  
Tamar Smith-Norowitz ◽  
Stephan Kohlhoff
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Chlamydia Pneumoniae ◽  
Mononuclear Cells ◽  
Inhaled Corticosteroid ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Asthma Patients ◽  
Ifn Γ

Abstract Background Chlamydia pneumoniae (Cpn) is unique in its ability to cause chronic infections, potentially triggering asthma exacerbations as well as subsequent asthma development. Th1-mediated immunity and IFN-γ are critical for clearing chlamydial infections. Persistent or recent Cpn infection may be identified in vitro by detecting T-helper cytokine IFN-γ produced by peripheral blood mononuclear cells (PBMC) stimulated by Cpn. Inhaled corticosteroids (ICS) may have an inhibitory effect on IFN-γ. Prior studies have shown increased Th2 responses upon in vitro Cpn stimulation with increased age. Our aim was to determine whether age and inhaled corticosteroid (ICS) use affect Cpn-induced PBMC produced IFN-γ levels. Methods Pediatric and adult subjects with (n = 23) and without (n = 10) asthma were enrolled. PBMC obtained from all subjects were stimulated with Cpn (MOI = 0.1 x48h) in vitro. IFN-γ levels in culture supernatants were determined by ELISA and reported as pg/mL. Nasopharyngeal (NP) swabs were tested for Cpn using Real-Time PCR. Statistical analysis for continuous variables was performed using the Mann–Whitney U test. Results None of the subjects were positive for Cpn by PCR on NP swab. Levels of IFN-γ produced by PBMC stimulated by Cpn were similar between asthmatic vs. control subjects (41.7 vs. 68.8, respectively; P = 0.72) and between pediatric and adult subjects with asthma (IFN-γ 54 vs. 20.1 respectively, P = 0.95). Pediatric subjects with asthma who received ICS had lower IFN-γ levels than those who did not (median IFN-γ 25.5 vs. 209; P = 0.003). Conclusion Our finding of lower IFN-γ levels among asthma patients on ICS compared with those not on ICS suggests that ICS use may dampen the systemic inflammatory response. While we did not find a statistically significant difference between pediatric and adult age groups in this pilot study, there was a trend to higher Cpn-induced IFN-γ levels among younger pediatric subjects. Future prospective studies should further define predictors of diminished IFN-γ responses in patients with asthma. Disclosures All authors: No reported disclosures.

Loss of Control of Asthma Following Inhaled Corticosteroid Withdrawal Is Associated With Increased Sputum Interleukin-8 and Neutrophils

CHEST Journal ◽  
2007 ◽  
Vol 132 (1) ◽  
pp. 98-105 ◽  
Author(s):  
Kittipong Maneechotesuwan ◽  
Sarah Essilfie-Quaye ◽  
Sergei A. Kharitonov ◽  
Ian M. Adcock ◽  
Peter J. Barnes
Keyword(s):  
Interleukin 8 ◽  
Loss Of Control ◽  
Inhaled Corticosteroid ◽  
Corticosteroid Withdrawal

scholarly journals Influence of the first wave of COVID-19 on asthma inhaler prescriptions

2021 ◽  
Vol 31 (1) ◽  
Author(s):  
C. I. Bloom ◽  
E. Wong ◽  
K. Hickman ◽  
S. Elkin
Keyword(s):  
Primary Care ◽  
Socioeconomic Status ◽  
Medical Records ◽  
Inhaled Corticosteroid ◽  
Asthma Patients ◽  
In The Beginning

AbstractIn the beginning of the COVID-19 pandemic, there were major concerns regarding the huge demand for asthma inhalers. Using the primary-care medical records for 614,700 asthma patients between January and June 2020, we found that there was a substantial increase in inhalers solely in March 2020. Patients significantly associated with receiving higher inhaled corticosteroid prescriptions were younger, of higher socioeconomic status, and had milder asthma.

Effectiveness of Russian inhaled corticosteroid beclomethasone in bronchial asthma patients

2011 ◽  
pp. 80-86
Author(s):  
E. I. Shmelev ◽  
A. F. Abubikirov ◽  
N. M. Shmeleva ◽  
M. M. Ilkovich ◽  
N. A. Kuzubova
Keyword(s):  
Bronchial Asthma ◽  
Inhaled Corticosteroid ◽  
Asthma Patients

scholarly journals The golden factor in adherence to inhaled corticosteroid in asthma patients

2013 ◽  
Vol 62 (3) ◽  
pp. 371-376 ◽  
Author(s):  
Nizar Rifaat ◽  
Elham Abdel-Hady ◽  
Ali A. Hasan
Keyword(s):  
Inhaled Corticosteroid ◽  
Asthma Patients
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