scholarly journals Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma

2020 ◽  
Author(s):  
J.M. Daly ◽  
Z. Yang ◽  
J.L. Ingram ◽  
K.M. Luginbuhl ◽  
A. Varanko ◽  
...  
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Airway Hyperresponsiveness ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Co-Purification of Recombinant Modified Glucagon-Like and Glucose-Dependent Insulinotropic Peptide to Create a Two-Component Drug for the Treatment of Type 2 Diabetes Mellitus and Obesity

2021 ◽  
Vol 37 (6) ◽  
pp. 74-83
Author(s):  
A.Yu. Gorbunova ◽  
E.P. Sannikova ◽  
I.I. Gubaidullin ◽  
O.M. Ignatova ◽  
M.Yu. Kopaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Model ◽  
Specific Activity ◽  
Two Component ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Insulinotropic Peptide

In addition to the previously developed recombinant modified human glucagon-like peptide 1 (rmglp1, Glypin), a recombinant modified human glucose-dependent insulinotropic peptide (RMGIP) has been obtained. A new universal reverse-phase HPLC technique has been proposed allowing quantitative analysis of rmGlp1 and rmGip separately and as part of a two-component preparation. The data show that the design of recombinant human rmGip according to the Glypine formula makes it possible to produce one-component and two-component preparations containing various rmGip and rmGlp1 protein ratios ranging from 1:0 to 20:1, using cell biomass samples mixed in predetermined proportions. Studies of human rmGip activity in a mouse model revealed reduced specific activity and signs of weak antagonistic effects. In this regard, there is a need for further study of human rmGip activity in a mouse model, including the use of alternative mouse or rat rmGip. type 2 diabetes mellitus; two-component drug, glucose-dependent insulinotropic peptide, glucagon-like peptide-1 The work was supported by the Internal Grant from National Research Center Kurchatov Institute.

Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma

2011 ◽  
Vol 11 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Ji-Eun Yuk ◽  
Mee-Young Lee ◽  
Ok-Kyoung Kwon ◽  
Xing-Fu Cai ◽  
Ha-Young Jang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Airway Hyperresponsiveness

scholarly journals A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity

Circulation ◽  
2013 ◽  
Vol 127 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Mohammad Hossein Noyan-Ashraf ◽  
Eric Akihiko Shikatani ◽  
Irmgard Schuiki ◽  
Ilya Mukovozov ◽  
Jun Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Molecular Pathology ◽  
Cardiac Dysfunction ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Fenretinide Prevents Inflammation and Airway Hyperresponsiveness in a Mouse Model of Allergic Asthma

2014 ◽  
Vol 51 (6) ◽  
pp. 783-792 ◽  
Author(s):  
Cynthia Kanagaratham ◽  
Alžběta Kalivodová ◽  
Lukáš Najdekr ◽  
David Friedecký ◽  
Tomáš Adam ◽  
...  
Keyword(s):  
Mouse Model ◽  
Allergic Asthma ◽  
Airway Hyperresponsiveness

scholarly journals Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

eNeuro ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. ENEURO.0031-19.2019 ◽  
Author(s):  
Stephen M. Day ◽  
Wenzhong Yang ◽  
Xin Wang ◽  
Jennifer E. Stern ◽  
Xueyan Zhou ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cognitive Function ◽  
Mouse Model ◽  
Cleavage Product ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
Sign in / Sign up

Export Citation Format

Share Document