Macrophage Dysfunction in Cystic Fibrosis: A Therapeutic Target to Enhance Self-Immunity

2015 ◽  
Vol 192 (12) ◽  
pp. 1406-1407 ◽  
Author(s):  
Tracey L. Bonfield
Keyword(s):  
Cystic Fibrosis ◽  
Therapeutic Target ◽  
Macrophage Dysfunction

Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target

2021 ◽  
Author(s):  
Thiago Inácio Teixeira do Carmo ◽  
Victor Emanuel Miranda Soares ◽  
Jonatha Wruck ◽  
Fernanda dos Anjos ◽  
Débora Tavares de Resende e Silva ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Therapeutic Target ◽  
Airway Surface Liquid ◽  
Purinergic System ◽  
Surface Liquid

PPARγ as a therapeutic target in cystic fibrosis

2012 ◽  
Vol 18 (5) ◽  
pp. 283-291 ◽  
Author(s):  
Johanna F. Dekkers ◽  
Cornelis K. van der Ent ◽  
Eric Kalkhoven ◽  
Jeffrey M. Beekman
Keyword(s):  
Cystic Fibrosis ◽  
Therapeutic Target

scholarly journals TGFβ as a therapeutic target in cystic fibrosis

2017 ◽  
Vol 22 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Elizabeth L. Kramer ◽  
John P. Clancy
Keyword(s):  
Cystic Fibrosis ◽  
Therapeutic Target

scholarly journals Low Levels of Insulin-like Growth Factor-1 Contribute to Alveolar Macrophage Dysfunction in Cystic Fibrosis

2013 ◽  
Vol 191 (1) ◽  
pp. 378-385 ◽  
Author(s):  
Jamie L. Bessich ◽  
Amanda B. Nymon ◽  
Lisa A. Moulton ◽  
Dana Dorman ◽  
Alix Ashare
Keyword(s):  
Cystic Fibrosis ◽  
Growth Factor ◽  
Alveolar Macrophage ◽  
Insulin Like Growth Factor ◽  
Macrophage Dysfunction ◽  
Low Levels

scholarly journals CXCR4+ granulocytes reflect fungal cystic fibrosis lung disease

2015 ◽  
Vol 46 (2) ◽  
pp. 395-404 ◽  
Author(s):  
Melanie Carevic ◽  
Anurag Singh ◽  
Nikolaus Rieber ◽  
Olaf Eickmeier ◽  
Matthias Griese ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Function ◽  
Lung Disease ◽  
Immune Cells ◽  
Therapeutic Target ◽  
Cystic Fibrosis Lung ◽  
Fungal Colonisation ◽  
Cystic Fibrosis Lung Disease ◽  
Potential Biomarker ◽  
Healthy Control

Cystic fibrosis airways are frequently colonised with fungi. However, the interaction of these fungi with immune cells and the clinical relevance in cystic fibrosis lung disease are incompletely understood.We characterised granulocytes in airway fluids and peripheral blood from cystic fibrosis patients with and without fungal colonisation, non-cystic fibrosis disease controls and healthy control subjects cross-sectionally and longitudinally and correlated these findings with lung function parameters.Cystic fibrosis patients with chronic fungal colonisation by Aspergillus fumigatus were characterised by an accumulation of a distinct granulocyte subset, expressing the HIV coreceptor CXCR4. Percentages of airway CXCR4+ granulocytes correlated with lung disease severity in patients with cystic fibrosis.These studies demonstrate that chronic fungal colonisation with A. fumigatus in cystic fibrosis patients is associated with CXCR4+ airway granulocytes, which may serve as a potential biomarker and therapeutic target in fungal cystic fibrosis lung disease.

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