scholarly journals The Pattern of Risk Factor Profile and Dutch Lipid Clinic Network Criteria of Familial Hypercholesterolemia in Egyptian Patients with Premature Coronary Heart Disease

2020 ◽  
Vol 4 (4) ◽  
pp. 203
Author(s):  
Ahmed Ellaien ◽  
Ashraf Reda ◽  
Ahmed Elkersh
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Familial Hypercholesterolemia ◽  
Risk Factor Profile ◽  
Premature Coronary Heart Disease ◽  
Lipid Clinic ◽  
Egyptian Patients

Lipoprotein(a) as a risk factor for coronary heart disease in heterozygous patients for familial hypercholesterolemia

1995 ◽  
Vol 115 ◽  
pp. S91
Author(s):  
C. Mussoni ◽  
L. Finazzo ◽  
A. Dormi ◽  
Z. Sangiorgi ◽  
S. Rimondi ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Familial Hypercholesterolemia ◽  
Lipoprotein A

scholarly journals The utility of MLPA in Familial Hypercholesterolemia diagnosis

2021 ◽  
Vol 67 (3) ◽  
pp. 162-166
Author(s):  
George Valeriu Moldovan ◽  
Adina Huțanu ◽  
Liliana Demian ◽  
Laszlo Hadadi ◽  
Bogdan Mănescu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Familial Hypercholesterolemia ◽  
Copy Number ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Copy Number Variations ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Premature Coronary Heart Disease

Abstract Background: Familial Hypercholesterolemia (FH) is an inherited disease, associated with an increased risk of atherosclerosis, manifested clinically as premature coronary heart disease. FH is biochemically characterized by increased Cholesterol and Low-density Lipoprotein Cholesterol serum levels. The diagnosis is often made using clinical scores however, the definitive FH diagnosis should point out the underlying molecular change, which can be: a point mutation within the three major genes, a number of single nucleotide polymorphisms determining the polygenic etiology, or copy number variations in the Low-density lipoprotein receptor gene. Objective: In the present study we investigated copy number variations as a possible etiological factor for FH in a cohort of patients with documented premature coronary heart disease. Methods: The study population consisted of 150 patients with premature coronary heart disease documented by angiography, all being under lipid-lowering therapy, and 20 apparently healthy controls. Serum lipids were assessed using the Cobas Integra 400 plus and commercial reagents. Copy number variations were evaluated with the SALSA MLPA Probemix P062 LDLR kit. Results: Cholesterol, Triglycerides, Low-density Lipoprotein Cholesterol and High-density Lipoprotein Cholesterol showed no difference between patients and controls. No copy number variations were detected in the investigated regions, namely all 18 exons and the promoter region of the Low-density lipoprotein receptor gene. Conclusions: Even in the presence of negative results, the Familial Hypercholesterolemia genetic diagnosis has to be further pursued in the presence of a clinical diagnosis, as the identification of the molecular etiology may bring additional clinical and therapeutical benefits, as well as open the possibility for “cascade screening”.

Lipoprotein(a). A genetic risk factor for premature coronary heart disease

JAMA ◽  
1992 ◽  
Vol 267 (24) ◽  
pp. 3326-3329 ◽  
Author(s):  
A. M. Scanu
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Lipoprotein A ◽  
Premature Coronary Heart Disease

P02.227 Comparison of the coronary heart disease risk factor profile of risperidone vs olanzapine treated patients

2000 ◽  
Vol 15 (S2) ◽  
pp. 382s-382s
Author(s):  
R.H. Bouchard ◽  
J. Villeneuve ◽  
N. Alméras ◽  
I. Simoneau ◽  
M.F. Demers ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Disease Risk Factor ◽  
Risk Factor Profile ◽  
Heart Disease Risk

scholarly journals Risk factor indicators in offspring of patients with premature coronary heart disease in Banja Luka region/Republic of Srpska/Bosnia and Herzegovina

2016 ◽  
Vol 4 ◽  
pp. 736-741 ◽  
Author(s):  
Dusko Vulic ◽  
Sasa Loncar ◽  
Miodrag Ostojic ◽  
Jelena Marinkovic ◽  
Branka Vulic ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Bosnia And Herzegovina ◽  
Premature Coronary Heart Disease ◽  
Banja Luka
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