Interleukin-1 Receptor Antagonist Inhibits Interleukin-8 Expression in A549 Respiratory Epithelial Cells InfectedIn Vitrowith a Replication-Deficient Recombinant Adenovirus Vector

1999 ◽  
Vol 21 (3) ◽  
pp. 388-394 ◽  
Author(s):  
Yehuda A. Schwarz ◽  
Raouf S. Amin ◽  
James M. Stark ◽  
Bruce C. Trapnell ◽  
Robert W. Wilmott
Keyword(s):  
Epithelial Cells ◽  
Receptor Antagonist ◽  
Recombinant Adenovirus ◽  
Interleukin 1 ◽  
Adenovirus Vector ◽  
Interleukin 8 ◽  
Respiratory Epithelial Cells ◽  
Interleukin 1 Receptor Antagonist ◽  
Recombinant Adenovirus Vector ◽  
Respiratory Epithelial

scholarly journals Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain

1995 ◽  
Vol 15 (4) ◽  
pp. 547-551 ◽  
Author(s):  
A. Lorris Betz ◽  
Guo-Yuan Yang ◽  
Beverly L. Davidson
Keyword(s):  
Brain Injury ◽  
Receptor Antagonist ◽  
Recombinant Adenovirus ◽  
Infarct Volume ◽  
Interleukin 1 ◽  
Adenovirus Vector ◽  
Histochemical Staining ◽  
Artery Occlusion ◽  
Central Administration ◽  
Interleukin 1 Receptor Antagonist

Adenoviruses have been proposed as potential vectors for gene therapy in the central nervous system, but there are no reports of their use in the treatment of a brain disease. Because central administration of interleukin-1 receptor antagonist protein (IL-1ra) reduces ischemic brain damage, we determined whether a recombinant adenovirus vector carrying the human IL-1ra cDNA (Ad.RSV IL-1ra) could be used to ameliorate brain injury in permanent focal ischemia. Groups of six rats received intraventricular injections of Ad.RSV IL-1ra or a control adenovirus containing the Escherichia coli β-galactosidase gene (Ad.RSV lacZ). Histochemical staining for β-galactosidase 5 days after virus injection indicated that transgene expression was confined primarily to the cells lining the ventricle. The concentrations of IL-1ra were fivefold to 50-fold higher in the Ad.RSV IL-1ra-injected animals, achieving levels of 9.1 ± 3.3 ng/g in brain and 23.7 ± 22.5 ng/ml in CSF. In these animals, cerebral infarct volume resulting from 24 h of permanent middle cerebral artery occlusion was reduced 64%. These studies demonstrate that adenoviral vectors can be used to deliver genes that attenuate brain injury.

Interleukin-1 receptor antagonist expression in epithelial cells of human endometrium

1995 ◽  
Vol 49 (3) ◽  
pp. 305-310 ◽  
Author(s):  
M. Fukuda ◽  
C. Azuma ◽  
T. Kanai ◽  
M. Koyama ◽  
T. Kimura ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Human Endometrium ◽  
Interleukin 1 Receptor Antagonist

Selective induction of interleukin-1 receptor antagonist and interleukin-8 in human monocytes by normal polyspecific IgG (intravenous immunoglobulin)

1995 ◽  
Vol 25 (5) ◽  
pp. 1267-1273 ◽  
Author(s):  
Valéria Ruiz de Souza ◽  
Marie-Paule Carreno ◽  
Srinivas V. Kaveri ◽  
Annick Ledur ◽  
Hoss Sadeghi ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Intravenous Immunoglobulin ◽  
Interleukin 1 ◽  
Interleukin 8 ◽  
Human Monocytes ◽  
Interleukin 1 Receptor Antagonist

Effect of Mycoplasma pneumoniae Lysate on Interleukin-8 Gene Expression in Human Respiratory Epithelial Cells

CHEST Journal ◽  
2005 ◽  
Vol 128 (1) ◽  
pp. 322-326 ◽  
Author(s):  
Myung Hyun Sohn ◽  
Kyung Eun Lee ◽  
Sung Yon Choi ◽  
Byoung Chul Kwon ◽  
Myung Woong Chang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Mycoplasma Pneumoniae ◽  
Interleukin 8 ◽  
Respiratory Epithelial Cells ◽  
Human Respiratory Epithelial Cells ◽  
Respiratory Epithelial
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