scholarly journals Pseudomonas aeruginosaFlagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5

2004 ◽  
Vol 30 (5) ◽  
pp. 627-634 ◽  
Author(s):  
Robert Adamo ◽  
Sach Sokol ◽  
Grace Soong ◽  
Marisa I. Gomez ◽  
Alice Prince
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Toll Like Receptor 5

scholarly journals Toll-like receptor 2 is upregulated by hog confinement dust in an IL-6-dependent manner in the airway epithelium

2008 ◽  
Vol 294 (6) ◽  
pp. L1049-L1054 ◽  
Author(s):  
K. L. Bailey ◽  
J. A. Poole ◽  
T. L. Mathisen ◽  
T. A. Wyatt ◽  
S. G. Von Essen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Chronic Bronchitis ◽  
Airway Epithelium ◽  
Airway Epithelial Cells ◽  
Dust Exposure ◽  
Dependent Manner ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2 ◽  
Tlr2 Mrna

Hog confinement workers are at high risk to develop chronic bronchitis as a result of their exposure to organic dust. Chronic bronchitis is characterized by inflammatory changes of the airway epithelium. A key mediator in inflammation is Toll-like receptor 2 (TLR2). We investigated the role of TLR2 in pulmonary inflammation induced by hog confinement dust. Normal human bronchial epithelial cells (NHBE) were grown in culture and exposed to hog confinement dust extract. Hog confinement dust upregulated airway epithelial cell TLR2 mRNA in a concentration- and time-dependent manner using real-time PCR. There was a similar increase in TLR2 protein at 48 h as shown by Western blot. TLR2 was upregulated on the surface of airway epithelial cells as shown by flow cytometry. A similar upregulation of pulmonary TLR2 mRNA and protein was shown in a murine model of hog confinement dust exposure. Hog confinement dust is known to stimulate epithelial cells to produce IL-6. To determine whether TLR2 expression was being regulated by IL-6, the production of IL-6 was blocked using an IL-6-neutralizing antibody. This resulted in attenuation of the dust-induced upregulation of TLR2. To further demonstrate the importance of IL-6 in the regulation of TLR2, NHBE were directly stimulated with recombinant human IL-6. IL-6 alone was able to upregulate TLR2 in airway epithelial cells. Hog confinement dust upregulates TLR2 in the airway epithelium through an IL-6-dependent mechanism.

scholarly journals SPLUNC1 regulation in airway epithelial cells: role of toll-like receptor 2 signaling

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Hong Wei Chu ◽  
Fabienne Gally ◽  
Jyoti Thaikoottathil ◽  
Yvonne M Janssen-Heininger ◽  
Qun Wu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

A20 Inhibits Toll-Like Receptor 2– and 4–Mediated Interleukin-8 Synthesis in Airway Epithelial Cells

2004 ◽  
Vol 31 (3) ◽  
pp. 330-336 ◽  
Author(s):  
Yasuhiro Gon ◽  
Yasukiyo Asai ◽  
Shu Hashimoto ◽  
Kenji Mizumura ◽  
Itsuro Jibiki ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Interleukin 8 ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Alcohol Functionally Upregulates Toll-Like Receptor 2 in Airway Epithelial Cells

2009 ◽  
Vol 33 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Kristina L. Bailey ◽  
Todd A. Wyatt ◽  
Debra J. Romberger ◽  
Joseph H. Sisson
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells

2012 ◽  
Vol 118 (4) ◽  
pp. 512-520 ◽  
Author(s):  
Shota Mizunoe ◽  
Tsuyoshi Shuto ◽  
Shingo Suzuki ◽  
Chizuru Matsumoto ◽  
Kenji Watanabe ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Cystic Fibrosis Airway ◽  
Toll Like Receptor 2

scholarly journals Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

2013 ◽  
Vol 87 (6) ◽  
pp. 3261-3270 ◽  
Author(s):  
I. Ioannidis ◽  
F. Ye ◽  
B. McNally ◽  
M. Willette ◽  
E. Flano
Keyword(s):  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Receptor Expression ◽  
Type I ◽  
Airway Epithelial ◽  
Toll Like Receptor ◽  
Type Iii
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