scholarly journals Regulation of COX-2 Expression and IL-6 Release by Particulate Matter in Airway Epithelial Cells

2009 ◽  
Vol 40 (1) ◽  
pp. 19-30 ◽  
Author(s):  
Yutong Zhao ◽  
Peter V. Usatyuk ◽  
Irina A. Gorshkova ◽  
Donghong He ◽  
Ting Wang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Cox 2

Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids

2002 ◽  
Vol 283 (3) ◽  
pp. L612-L618 ◽  
Author(s):  
Helen C. Rodgers ◽  
Linhua Pang ◽  
Elaine Holland ◽  
Lisa Corbett ◽  
Simon Range ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Epithelial Cells ◽  
A549 Cells ◽  
Airway Epithelial Cells ◽  
Prostaglandin E ◽  
Airway Epithelial ◽  
Neutrophilic Inflammation ◽  
Airway Diseases ◽  
Cox Inhibitor ◽  
Cox 2

Interleukin (IL)-8, the C-X-C chemokine, is a potent neutrophil chemoattractant that has been implicated in a number of inflammatory airway diseases such as cystic fibrosis. Here we tested the hypothesis that bradykinin, an inflammatory mediator and chloride secretagogue, would increase IL-8 generation in airway epithelial cells through autocrine generation of endogenous prostanoids. Bradykinin increased IL-8 generation in both a non-cystic fibrosis (A549) and cystic fibrosis epithelial cell line (CFTE29[Formula: see text]) that was inhibited by the nonselective cyclooxygenase (COX) inhibitor indomethacin and the COX-2 selective inhibitor NS-398. COX-2 was the only isoform of COX expressed in both cell lines. Furthermore, the COX substrate arachidonic acid and exogenous prostaglandin E2 both increased IL-8 release in A549 cells. These results suggest that bradykinin may contribute to neutrophilic inflammation in the airway by generation of IL-8 from airway epithelial cells. The dependence of this response on endogenous production of prostanoids by COX-2 suggests that selective COX-2 inhibitors may have a role in the treatment of airway diseases characterized by neutrophilic inflammation such as cystic fibrosis or chronic obstructive pulmonary disease.

Differential injurious effects of ambient and traffic-derived particulate matter on airway epithelial cells

Respirology ◽  
2014 ◽  
Vol 20 (1) ◽  
pp. 73-79 ◽  
Author(s):  
Rakesh K. Kumar ◽  
Alexander M. Shadie ◽  
Martin P. Bucknall ◽  
Helen Rutlidge ◽  
Linda Garthwaite ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Epithelial Cells ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Injurious Effects

Parainfluenza virus infection enhances NSAIDs–induced inhibition of PGE2 generation and COX-2 expression in human airway epithelial cells

2019 ◽  
Vol 64 (2) ◽  
pp. 338-343 ◽  
Author(s):  
Anna Lewandowska-Polak ◽  
Małgorzata Brauncajs ◽  
Marzanna Jarzębska ◽  
Małgorzata Pawełczyk ◽  
Marcin Kurowski ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Airway Epithelial Cells ◽  
Parainfluenza Virus ◽  
Airway Epithelial ◽  
Human Airway ◽  
Cox 2 ◽  
Human Airway Epithelial Cells
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