Improved Biological Properties of Calcium Phosphate Cement by Nacre Incorporation: An In Vitro Study

2018 ◽  
Vol 8 (1) ◽  
pp. 67-79
Author(s):  
Rui Ruan ◽  
Minghao Zheng ◽  
Junjie Gao ◽  
Euphemie Landao-Bassonga ◽  
Lianzhi Chen ◽  
...  
Biomaterials ◽  
2004 ◽  
Vol 25 (17) ◽  
pp. 3887-3894 ◽  
Author(s):  
E.M. Ooms ◽  
N. Verdonschot ◽  
J.G.C. Wolke ◽  
W.Van de Wijdeven ◽  
M.M.M. Willems ◽  
...  

1997 ◽  
Vol 23 (9) ◽  
pp. 588-592 ◽  
Author(s):  
James Y.M. Chau ◽  
Jeffrey W. Hutter ◽  
Thomas O. Mork ◽  
Brian K. Nicoll

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3075
Author(s):  
Sok Kuan Wong ◽  
Yew Hoong Wong ◽  
Kok-Yong Chin ◽  
Soelaiman Ima-Nirwana

Calcium phosphate cement (CPC) is a promising material used in the treatment of bone defects due to its profitable features of self-setting capability, osteoconductivity, injectability, mouldability, and biocompatibility. However, the major limitations of CPC, such as the brittleness, lack of osteogenic property, and poor washout resistance, remain to be resolved. Thus, significant research effort has been committed to modify and reinforce CPC. The mixture of CPC with various biological materials, defined as the materials produced by living organisms, have been fabricated by researchers and their characteristics have been investigated in vitro and in vivo. This present review aimed to provide a comprehensive overview enabling the readers to compare the physical, mechanical, and biological properties of CPC upon the incorporation of different biological materials. By mixing the bone-related transcription factors, proteins, and/or polysaccharides with CPC, researchers have demonstrated that these combinations not only resolved the lack of mechanical strength and osteogenic effects of CPC but also further improve its own functional properties. However, exceptions were seen in CPC incorporated with certain proteins (such as elastin-like polypeptide and calcitonin gene-related peptide) as well as blood components. In conclusion, the addition of biological materials potentially improves CPC features, which vary depending on the types of materials embedded into it. The significant enhancement of CPC seen in vitro and in vivo requires further verification in human trials for its clinical application.


2016 ◽  
Vol 42 (1) ◽  
pp. 1660-1665 ◽  
Author(s):  
Yanxia Zheng ◽  
Gang Dong ◽  
Liyong He ◽  
Gang Wu ◽  
Huade Zheng ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document