Role of Notch and Wnt Signaling in Differentiation of Human Hair Follicle Stem Cells

2019 ◽  
Vol 11 (3) ◽  
pp. 346-353
Author(s):  
Jindou Jiang ◽  
Xuekun Wang ◽  
Yuan Ye ◽  
Jingjiang Zou ◽  
Yarui Liu ◽  
...  
2015 ◽  
Vol 05 (999) ◽  
pp. 1-1
Author(s):  
Abu Bakar Mohd Hilmi ◽  
Mohd Noor Norhayati ◽  
Ahmad Sukari Halim ◽  
Chin Keong Lim ◽  
Zulkifli Mustafa ◽  
...  

2011 ◽  
Vol 44 (3) ◽  
pp. 244-253 ◽  
Author(s):  
J. H. Oh ◽  
P. Mohebi ◽  
D. L. Farkas ◽  
J. Tajbakhsh

1998 ◽  
Vol 111 (21) ◽  
pp. 3179-3188 ◽  
Author(s):  
S. Lyle ◽  
M. Christofidou-Solomidou ◽  
Y. Liu ◽  
D.E. Elder ◽  
S. Albelda ◽  
...  

Stem cells are vital for the homeostasis of self-renewing tissues such as the hair follicle. Epithelial stem cells have been implicated in tumorigenesis and wound healing, and their manipulation may have wide ranging applications including gene therapy and tissue transplantation. Rodent hair follicle stem cells have been localized to an area of the follicle called the bulge, however, the identification and characterization of human hair follicle stem cells has been hampered by a lack of cellular markers for this area. We have determined that the C8/144B monoclonal antibody, originally generated against a short intracytoplasmic peptide of CD8, preferentially immunostains hair follicle bulge keratinocytes without staining the remaining hair follicle. Using expression cloning, we identified cytokeratin 15 as the keratinocyte protein recognized by the C8/144B monoclonal antibody. By delineating the bulge using this antibody, we demonstrated that bulge cells possess a stem cell phenotype characterized by their slowly-cycling nature, preferential proliferation at the onset of new hair follicle growth, high level of beta1 integrin expression, and expression of cytokeratin 19.


2018 ◽  
Vol 45 (12) ◽  
pp. 1403-1410 ◽  
Author(s):  
Katsuma Miyachi ◽  
Takaaki Yamada ◽  
Mika Kawagishi-Hotta ◽  
Yuichi Hasebe ◽  
Yasushi Date ◽  
...  

2021 ◽  
Vol 520 ◽  
pp. 111096
Author(s):  
Julieta María Ceruti ◽  
Florencia Maia Oppenheimer ◽  
Gustavo José Leirós ◽  
María Eugenia Balañá

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