Detecting Early to Mild Glaucomatous Damage: A Comparison of the Multifocal VEP and Automated Perimetry

2004 ◽  
Vol 45 (2) ◽  
pp. 492 ◽  
Author(s):  
Donald C. Hood ◽  
Phamornsak Thienprasiddhi ◽  
Vivienne C. Greenstein ◽  
Bryan J. Winn ◽  
Nitin Ohri ◽  
...  
Keyword(s):  
Automated Perimetry ◽  
Glaucomatous Damage ◽  
Multifocal Vep

scholarly journals A simplified combined index of structure and function for detecting and staging glaucomatous damage

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhichao Wu ◽  
Felipe A. Medeiros
Keyword(s):  
Clinical Utility ◽  
Mean Deviation ◽  
Automated Perimetry ◽  
Measurement Scales ◽  
Empirical Formulas ◽  
Fiber Layer ◽  
Glaucomatous Damage ◽  
Functional Changes ◽  
Cell Counts ◽  
Better Than

AbstractGlaucomatous damage results in characteristics structural and functional changes on optical coherence tomography (OCT) imaging and standard automated perimetry (SAP) testing. The clinical utility of these measures differs based on disease severity, as they are evaluated along different measurement scales. This study therefore sought to examine if a simplified combined structure–function index (sCSFI) could improve the detection and staging of glaucomatous damage, compared to the use of average retinal nerve fiber layer thickness (RNFL) measurements from OCT and mean deviation (MD) values from SAP alone, and also an estimated retinal ganglion cell counts (eRGC) measure derived using empirical formulas described previously. Examining 577 eyes from 354 participants with perimetric glaucoma and 241 normal eyes from 138 healthy participants, we found that the sCSFI performed significantly better than average RNFL, MD and eRGC count for discriminating between glaucoma and healthy eyes (P ≤ 0.008 for all). The sCSFI also performed significantly better than RNFL and eRGC count at discriminating between different levels of visual field damage in glaucoma eyes (P < 0.001 for both). These findings highlight the clinical utility of combining structural and functional information for detecting and staging glaucomatous damage using the simplified index developed in this study.

scholarly journals Investigating the structure‐function relationship using Goldmann V standard automated perimetry where glaucomatous damage is advanced

2019 ◽  
Vol 39 (6) ◽  
pp. 441-450
Author(s):  
Mieko Yanagisawa ◽  
Hiroshi Murata ◽  
Masato Matsuura ◽  
Yuri Fujino ◽  
Kazunori Hirasawa ◽  
...  
Keyword(s):  
Structure Function ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Glaucomatous Damage ◽  
Structure Function Relationship ◽  
Function Relationship

Glaucomatous Damage Patterns by Short-Wavelength Automated Perimetry (SWAP) in Glaucoma Suspects

2002 ◽  
Vol 12 (1) ◽  
pp. 49-54 ◽  
Author(s):  
V. Polo ◽  
J.M. Larrosa ◽  
I. Pinilla ◽  
F. Gonzalvo ◽  
A. Ferreras ◽  
...  
Keyword(s):  
Short Wavelength ◽  
Automated Perimetry ◽  
Glaucomatous Damage

Effect of refractive errors on multifocal VEP responses and standard automated perimetry tests in a single population

2014 ◽  
Vol 128 (3) ◽  
pp. 179-189 ◽  
Author(s):  
Makoto Nakamura ◽  
Kei Kato ◽  
Seiko Kamata ◽  
Kumiko Ishikawa ◽  
Takayuki Nagai
Keyword(s):  
Refractive Errors ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Single Population ◽  
Multifocal Vep

scholarly journals The photopic negative response (PhNR): measurement approaches and utility in glaucoma

2020 ◽  
Vol 40 (12) ◽  
pp. 3565-3576
Author(s):  
Matteo Prencipe ◽  
Tommaso Perossini ◽  
Giampaolo Brancoli ◽  
Mario Perossini
Keyword(s):  
Optic Neuropathy ◽  
Negative Response ◽  
Photopic Negative Response ◽  
Diagnostic Process ◽  
Glaucomatous Optic Neuropathy ◽  
Specific Information ◽  
Automated Perimetry ◽  
Pattern Erg ◽  
Glaucomatous Damage ◽  
Additional Tool

Abstract Purpose Visual electrophysiological testing continues to generate interest among glaucoma experts because of its potential help in clarifying disease pathophysiology and promoting early detection of glaucomatous damage. The photopic negative response (PhNR) is a slow negative component of the full-field electroretinogram that has been shown to provide specific information about retinal ganglion cells (RGCs) activity. The purpose of this article is to review the literature to explore the currently available measurement methods and the utility of PhNR in glaucoma diagnostic process. Methods We gathered publications related to the origins, types of stimuli used, measurements methods and applications of the PhNR of ERG in animal models and humans through a search of the literature cited in PubMed. Search terms were: “PhNR”, “photopic negative response”, “glaucoma”, “glaucomatous optic neuropathy”, “ERG”, “electroretinogram”. Results The most reliable PhNR measurements are obtained using a red stimulus on a blue background, without requiring refractive correction, fixation monitoring, or ocular media transparency. Given its direct correlation with RGCs response, the PhNR measured as baseline-to-trough (BT) represents the most reliable parameter of evaluation. Glaucoma patients with evident perimetric defects show pathologic PhNR values. Even though the PhNR is promising in detecting early RGCs impairment, distinguishing between healthy subjects and suspect patients at risk of developing glaucomatous damage still remains challenging. Conclusion The PhNR is a useful additional tool to explore disorders that affect the innermost retina, including glaucoma and other forms of optic neuropathy. In particular, comparing reports of the standard examinations (optic disc assessment, OCT RNFL measurement, standard automated perimetry) with the results of electrophysiological tests may be helpful in solving clinical diagnostic and management dilemmas. On the one hand, the PhNR of the ERG can examine the parvocellular pathways; on the other hand, the steady-state pattern ERG optimized for glaucoma screening (PERGLA) can explore the magnocellular pathways. This could give ophthalmologists a useful feedback to identify early RGCs alterations suggestive of glaucoma, stratify the risk and potentially monitor disease progression.

scholarly journals The contribution of multifocal visual evoked potentials in patients with optic neuritis and multiple sclerosis: a review

2020 ◽  
Author(s):  
Paraskevas Zafeiropoulos ◽  
Andreas Katsanos ◽  
George Kitsos ◽  
Maria Stefaniotou ◽  
Ioannis Asproudis
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Visual Evoked Potential ◽  
Evoked Potential ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Multifocal Visual Evoked Potential ◽  
Published Evidence ◽  
Multifocal Vep ◽  
Visual Evoked

Abstract Purpose To review the evidence on the usefulness of the multifocal visual evoked potential (mfVEP) test in patients with optic neuritis (ON) and/or multiple sclerosis (MS). Methods We critically review key published evidence on the use of mfVEP in ON/MS patients and its association with other functional and structural tests. Results Multifocal VEP tests are useful in detecting abnormality in patients with ON/MS and monitor the progression of lesions (remyelination, atrophy). In addition, mfVEP has good correlation with conventional visual evoked potential (VEP), standard automated perimetry, optical coherence tomography and magnetic resonance imaging. In patients with ON, mfVEP might be useful in predicting the risk of conversion to MS.

scholarly journals Assessment of the Reliability of Standard Automated Perimetry in Regions of Glaucomatous Damage

Ophthalmology ◽  
2014 ◽  
Vol 121 (7) ◽  
pp. 1359-1369 ◽  
Author(s):  
Stuart K. Gardiner ◽  
William H. Swanson ◽  
Deborah Goren ◽  
Steven L. Mansberger ◽  
Shaban Demirel
Keyword(s):  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Glaucomatous Damage

Comparing Multifocal VEP and Standard Automated Perimetry in High-Risk Ocular Hypertension and Early Glaucoma

2007 ◽  
Vol 48 (3) ◽  
pp. 1173 ◽  
Author(s):  
Brad Fortune ◽  
Shaban Demirel ◽  
Xian Zhang ◽  
Donald C. Hood ◽  
Emily Patterson ◽  
...  
Keyword(s):  
High Risk ◽  
Ocular Hypertension ◽  
Automated Perimetry ◽  
Standard Automated Perimetry ◽  
Early Glaucoma ◽  
Multifocal Vep

Predicting the Scalp Potential Topography in the Multifocal VEP by fMRI

2009 ◽  
Vol 3 ◽  
Author(s):  
Strasburger Hans
Keyword(s):  
Multifocal Vep
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