Author Response: On Alternative Methods for Measuring Visual Field Decay: Tobit Linear Regression

2012 ◽  
Vol 53 (1) ◽  
pp. 118 ◽  
Author(s):  
Joseph Caprioli ◽  
Dennis Mock ◽  
Elena Bitrian ◽  
Abdelmonem Afifi ◽  
Fei Yu ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Alternative Methods ◽  
Author Response ◽  
Field Decay

scholarly journals Trends in the Retinal Nerve Fiber Layer Thickness Changes with Different Degrees of Visual Field Defects

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Wenhui Geng ◽  
Dabo Wang ◽  
Jing Han
Keyword(s):  
Regression Analysis ◽  
Visual Field ◽  
Linear Regression ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Linear Regression Analysis ◽  
Simple Linear Regression ◽  
Fiber Layer ◽  
Simple Linear Regression Analysis ◽  
Rnfl Thickness

Purpose. To explore the disease progression of primary open-angle glaucoma (POAG) in individuals with different degrees of VF defects by analyzing the trends in retinal nerve fiber layer (RNFL) changes at each stage. Methods. A total of 39 patients (77 eyes) were divided into three groups based on the severity of glaucomatous visual field (VF) loss: the first group included patients with mild baseline VF defects (mild group; n = 21 eyes). The second group included patients with moderate VF defects (moderate group; n = 18 eyes). The third group included patients with severe baseline VF defects (severe group; n = 38 eyes). For all patients, slit-lamp biomicroscopy of the anterior and posterior segments and detailed fundus and optic disc inspections were performed, the intraocular pressure (IOP) was measured by Goldman tonometry, best-corrected visual acuity (BCVA) was measured, the RNFL thickness was measured by OCT, and the VF was assessed by the Octopus perimeter. All the groups were followed up postoperatively for 18 months. Results. The mean RNFL thickness was recorded for all the visits. Using simple linear regression analysis, we found that the R2 values of the three groups were 0.988, 0.982, and 0.814, respectively, and the slopes of mean RNFL thickness changes for mild, moderate, and severe baseline VF defects were −0.088, −0.082, and −0.015, respectively. Moreover, we used simple linear regression analysis to explore whether and how the speed of RNFL thinning differs across groups. The R2 values of the three groups were 0.982, 0.978, and 0.805, respectively, and the slopes for mild, moderate, and severe baseline VF defects were 0.089, 0.085, and 0.017, respectively. Conclusion. The rate of RNFL thinning is linear; RNFL thinning is the fastest in individuals with mild baseline VF defects, followed by those with moderate baseline VF defects. In individuals with severe VF defects, changes in the RNFL thickness do not appropriately reflect the progression of the disease. The clinical trial is registered with ChiCTR2000028975.

Author response for "Evaluation of multiple linear regression applied to impedimetric sensing"

2020 ◽  
Author(s):  
Dayvison Ribeiro Rodrigues ◽  
Wallace Duarte Fragoso ◽  
Sherlan Guimarães Lemos
Keyword(s):  
Linear Regression ◽  
Multiple Linear Regression ◽  
Author Response

Comparing the usefulness of a new algorithm to measure visual field using the variational Bayes linear regression in glaucoma patients, in comparison to the Swedish interactive thresholding algorithm

2021 ◽  
pp. bjophthalmol-2020-318304
Author(s):  
Hiroshi Murata ◽  
Ryo Asaoka ◽  
Yuri Fujino ◽  
Masato Matsuura ◽  
Kazunori Hirasawa ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Open Angle Glaucoma ◽  
Variational Bayes ◽  
Mean Deviation ◽  
Test Duration ◽  
Field Analyser ◽  
Measurement Duration ◽  
Measurement Algorithm ◽  
Thresholding Algorithm

Background/aimsWe previously reported that the visual field (VF) prediction model using the variational Bayes linear regression (VBLR) is useful for accurately predicting VF progression in glaucoma (Invest Ophthalmol Vis Sci. 2014, 2018). We constructed a VF measurement algorithm using VBLR, and the purpose of this study was to investigate its usefulness.Method122 eyes of 73 patients with open-angle glaucoma were included in the current study. VF measurement was performed using the currently proposed VBLR programme with AP-7700 perimetry (KOWA). VF measurements were also conducted using the Swedish interactive thresholding algorithm (SITA) standard programme with Humphrey field analyser. VF measurements were performed using the 24–2 test grid. Visual sensitivities, test–retest reproducibility and measurement duration were compared between the two algorithms.ResultMean mean deviation (MD) values with SITA standard were −7.9 and −8.7 dB (first and second measurements), whereas those with VBLR-VF were −8.2 and −8.0 dB, respectively. There were no significant differences across these values. The correlation coefficient of MD values between the 2 algorithms was 0.97 or 0.98. Test–retest reproducibility did not differ between the two algorithms. Mean measurement duration with SITA standard was 6 min and 02 s or 6 min and 00 s (first or second measurement), whereas a significantly shorter duration was associated with VBLR-VF (5 min and 23 s or 5 min and 30 s).ConclusionVBLR-VF reduced test duration while maintaining the same accuracy as the SITA-standard.

scholarly journals Alternative methods of linear regression

2002 ◽  
Vol 35 (3-4) ◽  
pp. 361-374 ◽  
Author(s):  
A. Giloni ◽  
M. Padberg
Keyword(s):  
Linear Regression ◽  
Alternative Methods

Validating the efficacy of the binomial pointwise linear regression method to detect glaucoma progression with multicentral database

2019 ◽  
Vol 104 (4) ◽  
pp. 569-574
Author(s):  
Shotaro Asano ◽  
Hiroshi Murata ◽  
Masato Matsuura ◽  
Yuri Fujino ◽  
Atsuya Miki ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Trend Analysis ◽  
Predictive Value ◽  
False Positive Rate ◽  
Linear Regression Method ◽  
Trend Analyses ◽  
Total Deviation ◽  
Positive Rate ◽  
Test Points

Background/aimWe previously reported the benefit of applying binomial pointwise linear regression (PLR: binomial PLR) to detect 10–2 glaucomatous visual field (VF) progression. The purpose of the current study was to validate the usefulness of the binomial PLR to detect glaucomatous VF progression in the central 24°.MethodsSeries of 15 VFs (Humphrey Field Analyzer 24–2 SITA-standard) from 341 eyes of 233 patients, obtained over 7.9±2.1 years (mean±SD), were investigated. PLR was performed by regressing the total deviation of all test points. VF progression was determined from the VF test points analyses using the binomial test (one side, p<0.025). The time needed to detect VF progression was compared across the binomial PLR, permutation analysis of PLR (PoPLR) and mean total deviation (mTD) trend analysis.ResultsThe binomial PLR was comparable with PoPLR and mTD trend analyses in the positive predictive value (0.18–0.87), the negative predictive value (0.89–0.95) and the false positive rate (0.057–0.35) to evaluate glaucomatous VF progression. The time to classify progression with binomial PLR (5.8±2.8 years) was significantly shorter than those with mTD trend analysis (6.7±2.8 years) and PoPLR (6.6±2.7 years).ConclusionsThe binomial PLR method, which detected glaucomatous VF progression in the central 24° significantly earlier than PoPLR and mTD trend analyses, shows promise for improving our ability to detect visual field progression for clinical management of glaucoma and in clinical trials of new glaucoma therapies.

Low-cost, smartphone-based frequency doubling technology visual field testing using a head-mounted display

2019 ◽  
pp. bjophthalmol-2019-314031 ◽  
Author(s):  
Karam AlRahman Alawa ◽  
Ryan P Nolan ◽  
Elaine Han ◽  
Alejandro Arboleda ◽  
Heather Durkee ◽  
...  
Keyword(s):  
Visual Field ◽  
Linear Regression ◽  
Open Angle Glaucoma ◽  
Low Cost ◽  
Frequency Doubling ◽  
Regression Analyses ◽  
Field Screening ◽  
Head Mounted Display ◽  
Frequency Doubling Technology ◽  
Significant Difference

BackgroundCurrent visual field screening machines are bulky and expensive, limiting their accessibility, affordability and use. We report the design and evaluation of a novel, portable, cost-effective system for glaucoma screening using smartphone-based visual field screening using frequency doubling technology (FDT) and a head-mounted display.MethodsNineteen eyes of 10 subjects with new-onset or chronic primary open angle glaucoma were tested and compared with the Humphrey Zeiss FDT and the newly developed Mobile Virtual Perimetry (MVP) FDT with the C-20 testing pattern. Mann-Whitney, Bland-Altman and linear regression analyses were performed to assess statistical difference, agreement and correlation, respectively, between the two devices.ResultsThe average age of the participants was 58±15 years. No statistically significant difference was found between the MVP FDT and the Humphrey Zeiss FDT (p>0.05). Bland-Altman and linear regression analyses demonstrated good agreement and correlation between the two devices.ConclusionThe MVP FDT is a low-cost, portable visual field screening device that produces comparable results to the Humphrey Zeiss FDT and may be used as an easily accessible screening tool for glaucoma.

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